Literature DB >> 23125029

Triple-helical recognition of RNA using 2-aminopyridine-modified PNA at physiologically relevant conditions.

Thomas Zengeya1, Pankaj Gupta, Eriks Rozners.   

Abstract

Peptide nucleic acids containing thymidine and 2-aminopyridine (M) nucleobases form stable and sequence-selective triple helices with double-stranded RNA at physiologically relevant conditions. The M-modified PNA showed unique RNA selectivity by having two orders of magnitude higher affinity for the double-stranded RNAs than for the same DNA sequences.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2012        PMID： 23125029      PMCID： PMC3756501          DOI： 10.1002/anie.201207925

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  18 in total

1.  Macrocyclic helix-threading peptides for targeting RNA.

Authors:  Malathy Krishnamurthy; Kristina Simon; Anita M Orendt; Peter A Beal
Journal:  Angew Chem Int Ed Engl       Date:  2007       Impact factor: 15.336

2.  The centrality of RNA.

Authors:  Phillip A Sharp
Journal:  Cell       Date:  2009-02-20       Impact factor: 41.582

Review 3.  Targeting RNA with small molecules.

Authors:  Jason R Thomas; Paul J Hergenrother
Journal:  Chem Rev       Date:  2008-03-25       Impact factor: 60.622

4.  Short peptide nucleic acids bind strongly to homopurine tract of double helical RNA at pH 5.5.

Authors:  Ming Li; Thomas Zengeya; Eriks Rozners
Journal:  J Am Chem Soc       Date:  2010-06-30       Impact factor: 15.419

5.  MicroRNA-192 and -215 are upregulated in human gastric cancer in vivo and suppress ALCAM expression in vitro.

Authors:  Z Jin; F M Selaru; Y Cheng; T Kan; R Agarwal; Y Mori; A V Olaru; J Yang; S David; J P Hamilton; J M Abraham; J Harmon; M Duncan; E A Montgomery; S J Meltzer
Journal:  Oncogene       Date:  2010-11-29       Impact factor: 9.867

6.  Triple helical recognition of pyrimidine inversions in polypurine tracts of RNA by nucleobase-modified PNA.

Authors:  Pankaj Gupta; Thomas Zengeya; Eriks Rozners
Journal:  Chem Commun (Camb)       Date:  2011-09-12       Impact factor: 6.222

7.  Studying RNA-RNA and RNA-protein interactions by isothermal titration calorimetry.

Authors:  Andrew L Feig
Journal:  Methods Enzymol       Date:  2009       Impact factor: 1.600

8.  Four base recognition by triplex-forming oligonucleotides at physiological pH.

Authors:  David A Rusling; Vicki E C Powers; Rohan T Ranasinghe; Yang Wang; Sadie D Osborne; Tom Brown; Keith R Fox
Journal:  Nucleic Acids Res       Date:  2005-05-23       Impact factor: 16.971

9.  High-affinity triplex targeting of double stranded DNA using chemically modified peptide nucleic acid oligomers.

Authors:  Mads E Hansen; Thomas Bentin; Peter E Nielsen
Journal:  Nucleic Acids Res       Date:  2009-05-27       Impact factor: 16.971

10.  miRBase: tools for microRNA genomics.

Authors:  Sam Griffiths-Jones; Harpreet Kaur Saini; Stijn van Dongen; Anton J Enright
Journal:  Nucleic Acids Res       Date:  2007-11-08       Impact factor: 16.971
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  26 in total

1.  Synthesis and properties of peptide nucleic acid labeled at the N-terminus with HiLyte Fluor 488 fluorescent dye.

Authors:  Dziyana Hnedzko; Dennis W McGee; Eriks Rozners
Journal:  Bioorg Med Chem       Date:  2016-07-06       Impact factor: 3.641

2.  Improvement of sequence selectivity in triple helical recognition of RNA by phenylalanine-derived PNA.

Authors:  Thomas Zengeya; Artem Gindin; Eriks Rozners
Journal:  Artif DNA PNA XNA       Date:  2013-10-08

3.  Nuclear magnetic resonance reveals a two hairpin equilibrium near the 3'-splice site of influenza A segment 7 mRNA that can be shifted by oligonucleotides.

Authors:  Andrew D Kauffmann; Scott D Kennedy; Walter N Moss; Elzbieta Kierzek; Ryszard Kierzek; Douglas H Turner
Journal:  RNA       Date:  2022-01-04       Impact factor: 4.942

4.  2-Methoxypyridine as a Thymidine Mimic in Watson-Crick Base Pairs of DNA and PNA: Synthesis, Thermal Stability, and NMR Structural Studies.

Authors:  Irina Novosjolova; Scott D Kennedy; Eriks Rozners
Journal:  Chembiochem       Date:  2017-09-26       Impact factor: 3.164

5.  Triplex-Forming Peptide Nucleic Acids with Extended Backbones.

Authors:  Vipin Kumar; Nikita Brodyagin; Eriks Rozners
Journal:  Chembiochem       Date:  2020-08-31       Impact factor: 3.164

6.  Context-Sensitive Cleavage of Folded DNAs by Loop-Targeting bPNAs.

Authors:  Yufeng Liang; Shiqin Miao; Jie Mao; Chris DeSantis; Dennis Bong
Journal:  Biochemistry       Date:  2020-06-23       Impact factor: 3.162

7.  Sequence selective recognition of double-stranded RNA at physiologically relevant conditions using PNA-peptide conjugates.

Authors:  Oluwatoyosi Muse; Thomas Zengeya; Juddy Mwaura; Dziyana Hnedzko; Dennis W McGee; Christof T Grewer; Eriks Rozners
Journal:  ACS Chem Biol       Date:  2013-06-12       Impact factor: 5.100

8.  Using triple-helix-forming Peptide nucleic acids for sequence-selective recognition of double-stranded RNA.

Authors:  Dziyana Hnedzko; Samwel K Cheruiyot; Eriks Rozners
Journal:  Curr Protoc Nucleic Acid Chem       Date:  2014-09-08

Review 9.  Unnatural bases for recognition of noncoding nucleic acid interfaces.

Authors:  Shiqin Miao; Yufeng Liang; Sarah Rundell; Debmalya Bhunia; Shekar Devari; Oliver Munyaradzi; Dennis Bong
Journal:  Biopolymers       Date:  2020-09-24       Impact factor: 2.505

10.  Pyridazine Nucleobase in Triplex-Forming PNA Improves Recognition of Cytosine Interruptions of Polypurine Tracts in RNA.

Authors:  Nikita Brodyagin; Ilze Kumpina; Justin Applegate; Martins Katkevics; Eriks Rozners
Journal:  ACS Chem Biol       Date:  2021-04-21       Impact factor: 5.100
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