Literature DB >> 23108878

Immunohistochemical analysis of connective tissue in patients with pelvic organ prolapse.

Nese Yucel1, Akın Usta, Kadir Guzin, Mehmet Kanter, Ergun Bilgic, Nurver Ozbay Ozel, Mustafa Ozgul.   

Abstract

The uterosacral ligaments are an important part of the pelvic support system. The objective of this study was to compare the expression of collagen type I and collagen type III in the uterosacral ligament biopsies from women with and without pelvic organ prolapse (POP). The uterosacral ligament biopsies were obtained from women with POP (n = 29) and non-POP subjects (n = 35). Immunohistochemistry for collagen type I and collagen type III was performed on formalin-fixed and paraffin-embedded sections. The two groups were matched for age, body mass index, parity and postmenopausal status. The expression of collagen type I (p < 0.001) and collagen type III (p < 0.0001) differed between women with POP and non-POP subjects. There was decreased expression of collagen type I and increased expression of collagen type III in uterosacral ligaments of women with POP compared with non-POP subjects. This difference indicates a possible relationship between POP and the immunohistochemical expression of collagen type I and collagen type III in uterosacral ligaments.

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Year:  2012        PMID： 23108878     DOI： 10.1007/s10735-012-9456-5

Source DB:  PubMed          Journal:  J Mol Histol        ISSN： 1567-2379            Impact factor:   2.611


  28 in total

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  11 in total

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