Literature DB >> 23107007

Skin ulcer caused by venous extravasation of heroin.

Maria G Onesti1, Paolo Fioramonti, Pasquale Fino, Diego Massera, Vittoria Amorosi, Nicolo Scuderi.   

Abstract

The accidental leakage of the compound, in this case heroin, from the veins where it is injected, causes the formation of tissue lesions. Similar mechanisms lead to progressive tissue necrosis, which, if not immediately treated, results in the loss of the relevant function. A 57-year-old man presented a skin lesion on the posterior region of the left forearm with extensive necrosis of skin and subcutaneous layer involving the underlying muscle planes, caused by a venous extravasation of heroin that he reports having injected himself. The wound size is 15 × 10 cm; it had a sanious, fibrinous, secreting and smelly bottom. In this period, the patient was subjected to daily focused dressing before debridement of the lesion through a collagenase plus hyaluronic acid ointment: Bionect Start®; (FIDIA Pharmaceutical, Abano, Italy). The therapeutic choice was rewarded with a complete resolution of the wound through a non-invasive technique and over a short period. Avoiding the hospitalisation of the patient achieved a reduction of risks for him and of the costs for the National Health Service (NHS). The Bionect Start®; (FIDIA Pharmaceutical) as well as allowing the healing of the wound also decreased significantly the pain felt by the patient, the amount of exudate and the bad smell improving in a non-negligible way his quality of life.
© 2012 The Authors. International Wound Journal © 2012 Medicalhelplines.com Inc and John Wiley & Sons Ltd.

Entities:  

Keywords:  Bionect Start®; Collagenase; Extravasation of heroin; Hyaluronic acid; Skin lesion

Mesh:

Substances:

Year:  2012        PMID: 23107007      PMCID: PMC7950968          DOI: 10.1111/j.1742-481X.2012.01110.x

Source DB:  PubMed          Journal:  Int Wound J        ISSN: 1742-4801            Impact factor:   3.315


  12 in total

1.  Using an esterified hyaluronan fleece to promote healing in difficult-to-treat wounds.

Authors:  D Hollander; T Schmandra; J Windolf
Journal:  J Wound Care       Date:  2000-11       Impact factor: 2.072

Review 2.  Debridement methods in wound care.

Authors:  I Anderson
Journal:  Nurs Stand       Date:  2006 Feb 22-28

Review 3.  Collagenase for enzymatic debridement: a systematic review.

Authors:  Janet Ramundo; Mikel Gray
Journal:  J Wound Ostomy Continence Nurs       Date:  2009 Nov-Dec       Impact factor: 1.741

Review 4.  Developing extravasation protocols and monitoring outcomes.

Authors:  D Camp-Sorrell
Journal:  J Intraven Nurs       Date:  1998 Jul-Aug

5.  Quantitative and objective evaluation of wound debriding properties of collagenase and fibrinolysin/desoxyribonuclease in a necrotic ulcer animal model.

Authors:  J R Mekkes; J E Zeegelaar; W Westerhof
Journal:  Arch Dermatol Res       Date:  1998-03       Impact factor: 3.017

6.  Management of pain associated with debridement of leg ulcers: a randomized, multicentre, pilot study comparing nitrous oxide-oxygen mixture inhalation and lidocaïne-prilocaïne cream.

Authors:  A Claeys; C Gaudy-Marqueste; V Pauly; F Pelletier; F Truchetet; T Boye; F Aubin; J L Schmutz; J J Grob; M A Richard
Journal:  J Eur Acad Dermatol Venereol       Date:  2010-06-21       Impact factor: 6.166

7.  [The significance of extravasation in oncological care].

Authors:  Gabriella Zatkóné Puskás
Journal:  Magy Onkol       Date:  2008-03

8.  [New therapeutic strategies for the treatment of difficult wounds].

Authors:  M G Onesti; Adriana Bitonti; P Fino; M Ciotti; N Scuderi
Journal:  G Chir       Date:  2008-05

9.  TNF/IL-1-inducible protein TSG-6 potentiates plasmin inhibition by inter-alpha-inhibitor and exerts a strong anti-inflammatory effect in vivo.

Authors:  H G Wisniewski; J C Hua; D M Poppers; D Naime; J Vilcek; B N Cronstein
Journal:  J Immunol       Date:  1996-02-15       Impact factor: 5.422

10.  Extravasational side effects of cytotoxic drugs: A preventable catastrophe.

Authors:  Jagdeep S Thakur; C G S Chauhan; Vijay K Diwana; Dayal C Chauhan; Anamika Thakur
Journal:  Indian J Plast Surg       Date:  2008-07
View more
  1 in total

1.  Atypical Ulcers: Diagnosis and Management.

Authors:  Agata Janowska; Valentina Dini; Teresa Oranges; Michela Iannone; Barbara Loggini; Marco Romanelli
Journal:  Clin Interv Aging       Date:  2019-12-10       Impact factor: 4.458

  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.