Literature DB >> 23105362

Reversal of diabetic retinopathy in streptozotocin induced diabetic rats using traditional Indian anti-diabetic plant,Azadirachta indica (L.).

Halim Eshrat M Ali Hussain1.   

Abstract

This study was carried out to investigate the effect of oral feeding of water extract of fresh leaves ofAzadirachta indica (Fam:Meliaceae) in streptozotocin induced diabetes and its associated retinopathy in rats. Treatment of the diabetic rats with aqueous extract of leaves ofA. indica at a dose of 250 mg/kg body weight for 16 weeks resulted in gradual but significant fall in blood glucose and improvement in serum total, LDL and HDL cholesterol and triacylglycerol which increased in diabetic rats. It also showed improvement in body weight and reversed retinopathy.

Entities:  

Keywords:  Azadirachta indica; diabetes mellitus; diabetic retinopathy; hypoglycemic effect; hypolipidemic effect

Year:  2002        PMID： 23105362      PMCID： PMC3454118          DOI： 10.1007/BF02867983

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN： 0970-1915


  6 in total

1.  Possible mechanism of antihyperglycemic effect of Azadirachta indica leaf extract. Part IV.

Authors:  R R Chattopadhyay
Journal:  Gen Pharmacol       Date:  1996-04

2.  Preliminary studies on the hypoglycaemic effect ofAbroma augusta in alloxan diabetic rats.

Authors:  H Eshrat; M A Hussain; K Jamil; M Rao
Journal:  Indian J Clin Biochem       Date:  2001-01

3.  Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice.

Authors:  F N Ziyadeh; B B Hoffman; D C Han; M C Iglesias-De La Cruz; S W Hong; M Isono; S Chen; T A McGowan; K Sharma
Journal:  Proc Natl Acad Sci U S A       Date:  2000-07-05       Impact factor: 11.205

4.  Effects of specific antagonists of angiotensin II receptors and captopril on diabetic nephropathy in mice.

Authors:  T Yotsumoto; T Naitoh; K Shikada; S Tanaka
Journal:  Jpn J Pharmacol       Date:  1997-09

5.  Medicinal plants for treatment of diabetes mellitus.

Authors:  R Shukia; S B Sharma; D Puri; K M Prabhu; P S Murthy
Journal:  Indian J Clin Biochem       Date:  2000-08

6.  Hypoglycaemic, hypolipidemic and antioxidant properties of tulsi (Ocimum sanctum linn) on streptozotocin induced diabetes in rats.

Authors:  E H Hussain; K Jamil; M Rao
Journal:  Indian J Clin Biochem       Date:  2001-07
  6 in total
  5 in total

1.  Antidiabetic Potentiality of the Aqueous-Methanolic Extract of Seed of Swietenia mahagoni (L.) Jacq. in Streptozotocin-Induced Diabetic Male Albino Rat: A Correlative and Evidence-Based Approach with Antioxidative and Antihyperlipidemic Activities.

Authors:  Debasis De; Kausik Chatterjee; Kazi Monjur Ali; Tushar Kanti Bera; Debidas Ghosh
Journal:  Evid Based Complement Alternat Med       Date:  2010-09-28       Impact factor: 2.629

2.  Effect ofCoccinia indica (L.) andAbroma augusta (L.) on glycemia, lipid profile and on indicators of end-organ damage in streptozotocin induced diabetic rats.

Authors:  M Halim Eshrat
Journal:  Indian J Clin Biochem       Date:  2003-07

3.  Effect ofOcimum sanctum (Tulsi) and vitamin E on biochemical parameters and retinopathy in streptozotocin induced diabetic rats.

Authors:  Eshrat M Halim; A K Mukhopadhyay
Journal:  Indian J Clin Biochem       Date:  2006-09

4.  The acaricidal efficacy of aqueous neem extract and ivermectin against Sarcoptes scabiei var. cuniculi in experimentally infested rabbits.

Authors:  Shaker A Seddiek; Hanem F Khater; Mohamed M El-Shorbagy; Ali M Ali
Journal:  Parasitol Res       Date:  2013-04-10       Impact factor: 2.289

5.  Effects of Mesembrrybryanthemum forsskalei Hochst seeds in lowering glucose/lipid profile in streptozotocin-induced diabetic rats.

Authors:  Nora A Al Faris; Zeid A Al Othman; Dilshad Ahmad
Journal:  J Food Sci Technol       Date:  2010-11-05       Impact factor: 2.701
  5 in total

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