Literature DB >> 23105316

Hypoglycaemic, hypolipidemic and antioxidant properties of tulsi (Ocimum sanctum linn) on streptozotocin induced diabetes in rats.

E H Hussain1, K Jamil, M Rao.   

Abstract

Effect of oral administration of 200 mg/Kg body weight of the aqueous extract ofOcimum sanctum (Tulsi) mixed with diet for eight weeks to diabetic (streptozotocin induced) rats was studied. There was significant reduction in fasting blood glucose, serum lipid profile, lipid peroxidation products, (LPO) and improvement in glucose tolerance. The aqueous extract also decreased LPO formation (thiobarbituric acid reactive substances TBARS) and increased antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX), glutathione transferase (GT) and one antioxidant reduced glutathione (GSH) in plasma and rat liver, lung, kidney and brain. The decrease in TBARS and increase in GSH, SOD, CAT, GPX, and GT clearly shows the antioxidant property ofOcimum sanctum.

Entities:  

Keywords:  Ocimum sanctum; antioxidants; diabetes mellitus; hypoglycemic effect; hypolipidemic effect; lipid peroxidation

Year:  2001        PMID： 23105316      PMCID： PMC3453628          DOI： 10.1007/BF02864859

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN： 0970-1915


  12 in total

1.  Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction.

Authors:  H Ohkawa; N Ohishi; K Yagi
Journal:  Anal Biochem       Date:  1979-06       Impact factor: 3.365

2.  Randomized placebo-controlled, single blind trial of holy basil leaves in patients with noninsulin-dependent diabetes mellitus.

Authors:  P Agrawal; V Rai; R B Singh
Journal:  Int J Clin Pharmacol Ther       Date:  1996-09       Impact factor: 1.366

3.  Preliminary studies on the hypoglycaemic effect ofAbroma augusta in alloxan diabetic rats.

Authors:  H Eshrat; M A Hussain; K Jamil; M Rao
Journal:  Indian J Clin Biochem       Date:  2001-01

4.  Effect of Tulasi (Ocimum sanctum) leaf powder supplementation on blood sugar levels, serum lipids and tissue lipids in diabetic rats.

Authors:  V Rai; U Iyer; U V Mani
Journal:  Plant Foods Hum Nutr       Date:  1997       Impact factor: 3.921

5.  Screening of Indian plants for biological activity: I.

Authors:  M L Dhar; M M Dhar; B N Dhawan; B N Mehrotra; C Ray
Journal:  Indian J Exp Biol       Date:  1968-10       Impact factor: 0.818

6.  Superoxide dismutase, reduced glutathione and TBA-reactive products in erythrocytes of patients with multiple sclerosis.

Authors:  G Polidoro; C Di Ilio; A Arduini; G La Rovere; G Federici
Journal:  Int J Biochem       Date:  1984

7.  Anti-stress activity of Ocimum sanctum Linn.

Authors:  K P Bhargava; N Singh
Journal:  Indian J Med Res       Date:  1981-03       Impact factor: 2.375

Review 8.  Role of oxidative stress in development of complications in diabetes.

Authors:  J W Baynes
Journal:  Diabetes       Date:  1991-04       Impact factor: 9.461

9.  Hypoglycemic effect of Ocimum sanctum leaf extract in normal and streptozotocin diabetic rats.

Authors:  R R Chattopadhyay
Journal:  Indian J Exp Biol       Date:  1993-11       Impact factor: 0.818

10.  Psychoneuroendocrine influences on immunocompetence and neoplasia.

Authors:  V Riley
Journal:  Science       Date:  1981-06-05       Impact factor: 47.728
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  7 in total

1.  Ocimum sanctum attenuates oxidative damage and neurological deficits following focal cerebral ischemia/reperfusion injury in rats.

Authors:  Ajmal Ahmad; Mohd Moshahid Khan; Syed Shadab Raza; Hayate Javed; Mohammad Ashafaq; Farah Islam; Mohammed M Safhi; Fakhrul Islam
Journal:  Neurol Sci       Date:  2012-01-26       Impact factor: 3.307

2.  Reversal of diabetic retinopathy in streptozotocin induced diabetic rats using traditional Indian anti-diabetic plant,Azadirachta indica (L.).

Authors:  Halim Eshrat M Ali Hussain
Journal:  Indian J Clin Biochem       Date:  2002-07

3.  Effect ofOcimum sanctum (Tulsi) and vitamin E on biochemical parameters and retinopathy in streptozotocin induced diabetic rats.

Authors:  Eshrat M Halim; A K Mukhopadhyay
Journal:  Indian J Clin Biochem       Date:  2006-09

4.  Hypoglycemic, hypolipidemic and antioxidant properties of combination ofCurcumin fromCurcuma longa, Linn, and partially purified product fromAbroma augusta, Linn. in streptozotocin induced diabetes.

Authors:  Halim Eshrat M Ali Hussain
Journal:  Indian J Clin Biochem       Date:  2002-07

Review 5.  Phytotherapy in the Management of Diabetes: A Review.

Authors:  Paolo Governa; Giulia Baini; Vittoria Borgonetti; Giulia Cettolin; Daniela Giachetti; Anna Rosa Magnano; Elisabetta Miraldi; Marco Biagi
Journal:  Molecules       Date:  2018-01-04       Impact factor: 4.411

6.  Anti-diabetic and anti-oxidative activity of fixed oil extracted from Ocimum sanctum L. leaves in diabetic rats.

Authors:  Thamolwan Suanarunsawat; Gun Anantasomboon; Chutchai Piewbang
Journal:  Exp Ther Med       Date:  2016-01-13       Impact factor: 2.447

7.  Detection of csgA gene in carbapenem-resistant Acinetobacter baumannii strains and targeting with Ocimum sanctum biocompounds.

Authors:  Saishree R Anchana; Smiline A S Girija; Shoba Gunasekaran; Vijayashree J Priyadharsini
Journal:  Iran J Basic Med Sci       Date:  2021-05       Impact factor: 2.699
  7 in total

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