| Literature DB >> 23104013 |
Elaine Y M Wong1, Mohi Ahmed, Pin-Xian Xu.
Abstract
The phosphatase-transactivator EYA1 interacts with the homeodomain protein SIX1 to form transcriptional activation complexes, which play essential roles in regulating cell proliferation, survival and induction of sensory and neuronal differentiation programs during inner ear development. Mutations of the Eya1 and Six1 genes cause profound developmental auditory defects in mice and humans. The molecular mechanisms and developmental processes controlled by the EYA1 and SIX1 complex in inner ear development and neurosensory fate induction are the focus of this review. Published by Elsevier B.V.Entities:
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Year: 2012 PMID： 23104013 PMCID： PMC6592049 DOI： 10.1016/j.heares.2012.09.009
Source DB: PubMed Journal: Hear Res ISSN： 0378-5955 Impact factor: 3.208