Literature DB >> 26667035

Multiple Functions of the Eya Phosphotyrosine Phosphatase.

Ilaria Rebay1.   

Abstract

Eyes absent (Eya), a protein conserved from plants to humans and best characterized as a transcriptional coactivator, is also the prototype for a novel class of eukaryotic aspartyl protein tyrosine phosphatases. This minireview discusses recent breakthroughs in elucidating the substrates and cellular events regulated by Eya's tyrosine phosphatase function and highlights some of the complexities, new questions, and surprises that have emerged from efforts to understand how Eya's unusual multifunctionality influences developmental regulation and signaling.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26667035      PMCID： PMC4760226          DOI： 10.1128/MCB.00976-15

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  94 in total

1.  Homologs of animal eyes absent (eya) genes are found in higher plants.

Authors:  Y Takeda; S Hatano; N Sentoku; M Matsuoka
Journal:  Mol Gen Genet       Date:  1999-08

2.  The HD domain defines a new superfamily of metal-dependent phosphohydrolases.

Authors:  L Aravind; E V Koonin
Journal:  Trends Biochem Sci       Date:  1998-12       Impact factor: 13.807

3.  DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.

Authors:  E P Rogakou; D R Pilch; A H Orr; V S Ivanova; W M Bonner
Journal:  J Biol Chem       Date:  1998-03-06       Impact factor: 5.157

4.  Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya.

Authors:  H Ohto; S Kamada; K Tago; S I Tominaga; H Ozaki; S Sato; K Kawakami
Journal:  Mol Cell Biol       Date:  1999-10       Impact factor: 4.272

5.  twin of eyeless, a second Pax-6 gene of Drosophila, acts upstream of eyeless in the control of eye development.

Authors:  T Czerny; G Halder; U Kloter; A Souabni; W J Gehring; M Busslinger
Journal:  Mol Cell       Date:  1999-03       Impact factor: 17.970

6.  Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia.

Authors:  P X Xu; J Adams; H Peters; M C Brown; S Heaney; R Maas
Journal:  Nat Genet       Date:  1999-09       Impact factor: 38.330

7.  The eye-specification proteins So and Eya form a complex and regulate multiple steps in Drosophila eye development.

Authors:  F Pignoni; B Hu; K H Zavitz; J Xiao; P A Garrity; S L Zipursky
Journal:  Cell       Date:  1997-12-26       Impact factor: 41.582

8.  Multiple roles of the eyes absent gene in Drosophila.

Authors:  N M Bonini; W M Leiserson; S Benzer
Journal:  Dev Biol       Date:  1998-04-01       Impact factor: 3.582

9.  The Drosophila eyes absent gene directs ectopic eye formation in a pathway conserved between flies and vertebrates.

Authors:  N M Bonini; Q T Bui; G L Gray-Board; J M Warrick
Journal:  Development       Date:  1997-12       Impact factor: 6.868

10.  EYA4, a novel vertebrate gene related to Drosophila eyes absent.

Authors:  G Borsani; A DeGrandi; A Ballabio; A Bulfone; L Bernard; S Banfi; C Gattuso; M Mariani; M Dixon; D Donnai; K Metcalfe; R Winter; M Robertson; R Axton; A Brown; V van Heyningen; I Hanson
Journal:  Hum Mol Genet       Date:  1999-01       Impact factor: 6.150
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  13 in total

1.  Structural and Functional Analyses of an Allosteric EYA2 Phosphatase Inhibitor That Has On-Target Effects in Human Lung Cancer Cells.

Authors:  Jothi Anantharajan; Hengbo Zhou; Lingdi Zhang; Taylor Hotz; Melanie Y Vincent; Melanie A Blevins; Anna E Jansson; John Wee Liang Kuan; Elizabeth Yihui Ng; Yee Khoon Yeo; Nithya Baburajendran; Grace Lin; Alvin W Hung; Joma Joy; Samarjit Patnaik; Juan Marugan; Pratyaydipta Rudra; Debashis Ghosh; Jeffrey Hill; Thomas H Keller; Rui Zhao; Heide L Ford; CongBao Kang
Journal:  Mol Cancer Ther       Date:  2019-07-08       Impact factor: 6.261

2.  Retinal Expression of the Drosophila eyes absent Gene Is Controlled by Several Cooperatively Acting Cis-regulatory Elements.

Authors:  Bonnie M Weasner; Brandon P Weasner; Sarah D Neuman; Arash Bashirullah; Justin P Kumar
Journal:  PLoS Genet       Date:  2016-12-08       Impact factor: 5.917

3.  First Insights into the Subterranean Crustacean Bathynellacea Transcriptome: Transcriptionally Reduced Opsin Repertoire and Evidence of Conserved Homeostasis Regulatory Mechanisms.

Authors:  Bo-Mi Kim; Seunghyun Kang; Do-Hwan Ahn; Jin-Hyoung Kim; Inhye Ahn; Chi-Woo Lee; Joo-Lae Cho; Gi-Sik Min; Hyun Park
Journal:  PLoS One       Date:  2017-01-20       Impact factor: 3.240

4.  Neuronal cell fate specification by the molecular convergence of different spatio-temporal cues on a common initiator terminal selector gene.

Authors:  Johannes Stratmann; Stefan Thor
Journal:  PLoS Genet       Date:  2017-04-17       Impact factor: 5.917

5.  Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression.

Authors:  Lingdi Zhang; Hengbo Zhou; Xueni Li; Rebecca L Vartuli; Michael Rowse; Yongna Xing; Pratyaydipta Rudra; Debashis Ghosh; Rui Zhao; Heide L Ford
Journal:  Nat Commun       Date:  2018-03-13       Impact factor: 14.919

6.  Aberrant methylation of EYA4 promotes epithelial-mesenchymal transition in esophageal squamous cell carcinoma.

Authors:  Mei Luo; Yuan Li; Xuejiao Shi; Wenhui Yang; Fang Zhou; Nan Sun; Jie He
Journal:  Cancer Sci       Date:  2018-05-26       Impact factor: 6.716

7.  EYA2 promotes lung cancer cell proliferation by downregulating the expression of PTEN.

Authors:  Zhaoming Li; Ran Qiu; Xia Qiu; Tian Tian
Journal:  Oncotarget       Date:  2017-12-02

8.  Mutations that impair Eyes absent tyrosine phosphatase activity in vitro reduce robustness of retinal determination gene network output in Drosophila.

Authors:  Trevor L Davis; Charlene S L Hoi; Ilaria Rebay
Journal:  PLoS One       Date:  2017-11-06       Impact factor: 3.240

9.  EYES ABSENT and TIMELESS integrate photoperiodic and temperature cues to regulate seasonal physiology in Drosophila.

Authors:  Antoine Abrieux; Yongbo Xue; Yao Cai; Kyle M Lewald; Hoang Nhu Nguyen; Yong Zhang; Joanna C Chiu
Journal:  Proc Natl Acad Sci U S A       Date:  2020-06-15       Impact factor: 11.205

10.  Identification of Key Signaling Pathways Orchestrating Substrate Topography Directed Osteogenic Differentiation Through High-Throughput siRNA Screening.

Authors:  Tugba Ozdemir; Daniel T Bowers; Xiang Zhan; Debashis Ghosh; Justin L Brown
Journal:  Sci Rep       Date:  2019-01-30       Impact factor: 4.379
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