INTRODUCTION: Anastomotic leakage is the most important complication after colorectal surgery. Its prognosis depends on its early diagnosis. C-reactive protein (CRP) has already shown its usefulness for the early detection of anastomotic leaks. Procalcitonin (PCT) is widely used in intensive care units and is more expensive, but its usefulness in the postoperative period of digestive surgery is not well established. PATIENTS AND METHODS: Between May 2010 and June 2011, 100 patients undergoing elective colorectal surgery were prospectively included in a database. CRP and PCT were measured before surgery and daily until postoperative day 4. All intraabdominal infections were considered as anastomotic leaks, regardless of their clinical impact and their management. The kinetics of PCT and CRP were recorded, as well as their accuracy for the detection of anastomotic fistula. RESULTS: The incidence of fistula was 13% and the overall mortality rate was 2%. Both CRP and PCT were significantly higher in patients with leakage. Areas under the receiver-operating characteristics (ROC) for CRP were higher than those for PCT each day. The best accuracy was obtained for CRP on postoperative day 4 (areas under the ROC curve were 0.869 for CRP and 0.750 for PCT). CONCLUSION: Procalcitonin is neither earlier nor more accurate than CRP for the detection of anastomotic leakage after elective colorectal surgery.
INTRODUCTION: Anastomotic leakage is the most important complication after colorectal surgery. Its prognosis depends on its early diagnosis. C-reactive protein (CRP) has already shown its usefulness for the early detection of anastomotic leaks. Procalcitonin (PCT) is widely used in intensive care units and is more expensive, but its usefulness in the postoperative period of digestive surgery is not well established. PATIENTS AND METHODS: Between May 2010 and June 2011, 100 patients undergoing elective colorectal surgery were prospectively included in a database. CRP and PCT were measured before surgery and daily until postoperative day 4. All intraabdominal infections were considered as anastomotic leaks, regardless of their clinical impact and their management. The kinetics of PCT and CRP were recorded, as well as their accuracy for the detection of anastomotic fistula. RESULTS: The incidence of fistula was 13% and the overall mortality rate was 2%. Both CRP and PCT were significantly higher in patients with leakage. Areas under the receiver-operating characteristics (ROC) for CRP were higher than those for PCT each day. The best accuracy was obtained for CRP on postoperative day 4 (areas under the ROC curve were 0.869 for CRP and 0.750 for PCT). CONCLUSION: Procalcitonin is neither earlier nor more accurate than CRP for the detection of anastomotic leakage after elective colorectal surgery.
Authors: Jose L Martinez; Ilka Bosco-Garate; Luis Manuel Souza-Gallardo; José D Méndez; Marco A Juárez-Oropeza; Ruben Román-Ramos; Eduardo Ferat-Osorio Journal: J Gastrointest Surg Date: 2019-02-01 Impact factor: 3.452
Authors: Denise E Yeung; Elizabeth Peterknecht; Shahab Hajibandeh; Shahin Hajibandeh; Andrew W Torrance Journal: Int J Colorectal Dis Date: 2021-02-08 Impact factor: 2.571
Authors: A Giardino; G Spolverato; P Regi; I Frigerio; F Scopelliti; R Girelli; Z Pawlik; P Pederzoli; C Bassi; G Butturini Journal: J Gastrointest Surg Date: 2016-05-20 Impact factor: 3.452
Authors: Olivier Facy; Brice Paquette; David Orry; Nicolas Santucci; Paul Rat; Patrick Rat; Christine Binquet; Pablo Ortega-Deballon Journal: Int J Colorectal Dis Date: 2017-04-06 Impact factor: 2.571