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Literature DB >> 23101617

A missing link in genotype-directed cancer therapy.

Abstract

Genotype-directed therapy holds great promise for the treatment of cancer, but crosstalk between signaling pathways often confounds simple genotype-drug response relationships. To deliver on the promise of precision medicine, a coordinated effort is needed to make a comprehensive inventory of the many signaling feedback circuits that exist in cancer cells.

Entities: Disease

Mesh：

Substances：
Antineoplastic Agents

Year: 2012 PMID： 23101617 DOI： 10.1016/j.cell.2012.10.014

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

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Cited

43 in total

1. Predicting functional gene interactions with the hierarchical interaction score.

Authors: Berend Snijder; Prisca Liberali; Mathieu Frechin; Thomas Stoeger; Lucas Pelkmans
Journal: Nat Methods Date: 2013-10-06 Impact factor: 28.547

Review 2. Adapting to stress - chaperome networks in cancer.

Authors: Suhasini Joshi; Tai Wang; Thaís L S Araujo; Sahil Sharma; Jeffrey L Brodsky; Gabriela Chiosis
Journal: Nat Rev Cancer Date: 2018-09 Impact factor: 60.716

Review 3. How does genome sequencing impact surgery?

Authors: Marlies S Reimers; Charla C Engels; Peter J K Kuppen; Cornelis J H van de Velde; Gerrit J Liefers
Journal: Nat Rev Clin Oncol Date: 2014-06-24 Impact factor: 66.675

4. Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping.

Authors: Christina Laufer; Bernd Fischer; Maximilian Billmann; Wolfgang Huber; Michael Boutros
Journal: Nat Methods Date: 2013-04-07 Impact factor: 28.547

5. Scaling up the systematic hunt for mammalian genetic interactions.

Authors: Traver Hart; Jason Moffat
Journal: Nat Methods Date: 2013-05 Impact factor: 28.547

6. An Atlas of the Human Kinome Reveals the Mutational Landscape Underlying Dysregulated Phosphorylation Cascades in Cancer.

Authors: Aleksandra Olow; Zhongzhong Chen; R Hannes Niedner; Denise M Wolf; Christina Yau; Aleksandr Pankov; Evelyn Pei Rong Lee; Lamorna Brown-Swigart; Laura J van 't Veer; Jean-Philippe Coppé
Journal: Cancer Res Date: 2016-02-26 Impact factor: 12.701

A missing link in genotype-directed cancer therapy.

1. Predicting functional gene interactions with the hierarchical interaction score.

Review 2. Adapting to stress - chaperome networks in cancer.

Review 3. How does genome sequencing impact surgery?

4. Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping.

5. Scaling up the systematic hunt for mammalian genetic interactions.

6. An Atlas of the Human Kinome Reveals the Mutational Landscape Underlying Dysregulated Phosphorylation Cascades in Cancer.

7. Dynamics inside the cancer cell attractor reveal cell heterogeneity, limits of stability, and escape.

Review 8. Prioritizing therapeutic targets using patient-derived xenograft models.

9. Application of Monte Carlo cross-validation to identify pathway cross-talk in neonatal sepsis.

Review 10. Targeting melanoma by small molecules: challenges ahead.