OBJECTIVE: Variations in testosterone levels are associated with several outcomes of aging. The present study aimed to examine the relationship between age-related decline of testosterone levels and changes in bone health status, handgrip strength, body fat percentage and fat-free mass. MATERIALS AND METHODS: A total of 335 Malaysian Chinese and Malay men aged 40 years and above were recruited for this study. Their body compositions, calcaneal speed of sound and handgrip strength were measured and their blood was collected. Linear regression analysis was done to examine the relationship among age, testosterone levels and outcomes of aging. RESULTS: The results indicated significant changes in all testosterone measurements, sex hormone binding globulin level, calcaneal speed of sound, handgrip strength, body fat percentage and fat-free mass with age (p < 0.05). Age-dependent decline in bioavailable and free testosterone levels were significantly associated with reduction in calcaneal speed of sound, fat-free mass and handgrip strength (p < 0.05). Age-dependent decline in the total testosterone level was significantly associated with an increase in body fat percentage among the elderly men (p < 0.05). CONCLUSION: Testosterone levels are associated with changes in outcome of aging such as bone health status, muscle strength and body composition, and the relationships are age-dependent.
OBJECTIVE: Variations in testosterone levels are associated with several outcomes of aging. The present study aimed to examine the relationship between age-related decline of testosterone levels and changes in bone health status, handgrip strength, body fat percentage and fat-free mass. MATERIALS AND METHODS: A total of 335 Malaysian Chinese and Malay men aged 40 years and above were recruited for this study. Their body compositions, calcaneal speed of sound and handgrip strength were measured and their blood was collected. Linear regression analysis was done to examine the relationship among age, testosterone levels and outcomes of aging. RESULTS: The results indicated significant changes in all testosterone measurements, sex hormone binding globulin level, calcaneal speed of sound, handgrip strength, body fat percentage and fat-free mass with age (p < 0.05). Age-dependent decline in bioavailable and free testosterone levels were significantly associated with reduction in calcaneal speed of sound, fat-free mass and handgrip strength (p < 0.05). Age-dependent decline in the total testosterone level was significantly associated with an increase in body fat percentage among the elderly men (p < 0.05). CONCLUSION:Testosterone levels are associated with changes in outcome of aging such as bone health status, muscle strength and body composition, and the relationships are age-dependent.
Authors: Kok-Yong Chin; Soelaiman Ima-Nirwana; Isa Naina Mohamed; Fairus Ahmad; Elvy Suhana Mohd Ramli; Amilia Aminuddin; Wan Zurinah Wan Ngah Journal: Int J Med Sci Date: 2014-01-05 Impact factor: 3.738
Authors: Kok-Yong Chin; Nie Yen Low; Alia Annessa Ain Kamaruddin; Wan Ilma Dewiputri; Ima-Nirwana Soelaiman Journal: Ther Clin Risk Manag Date: 2017-10-06 Impact factor: 2.423
Authors: Paulo Francisco de Almeida-Neto; Dihogo Gama de Matos; Vanessa Carla Monteiro Pinto; Paulo Moreira Silva Dantas; Tatianny de Macêdo Cesário; Luíz Felipe da Silva; Alexandre Bulhões-Correia; Felipe José Aidar; Breno Guilherme de Araújo Tinôco Cabral Journal: Int J Environ Res Public Health Date: 2020-08-05 Impact factor: 3.390