| Literature DB >> 23092895 |
Li Gan1, Jing Wang, Min Jiang, Hanah Bartlett, Defang Ouyang, Frank Eperjesi, Jianping Liu, Yong Gan.
Abstract
Ocular barriers and the poor water solubility of drug candidates present a number of problems for the development of ocular drug delivery systems. Recently, the emergence of lipid-based nanocarriers has provided a viable means of enhancing the bioavailability of ophthalmic formulations. A number of these formulations have been found to be clinically active and several others are currently undergoing clinical trials. In this review, the advantages of lipid-based nanocarriers as non-invasive topical ocular drug delivery systems are presented. Many systems, including emulsions, liposomes, cubosomes, niosomes and other lipid-based nanocarriers, are reviewed.Entities:
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Year: 2012 PMID： 23092895 DOI： 10.1016/j.drudis.2012.10.005
Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851