PURPOSE: Congenital diaphragmatic hernia (CDH) remains a challenging and life-threatening congenital anomaly. The aim was to evaluate whether treatment and survival has changed during the last decade. METHODS: We retrospectively analysed all consecutive infants with CDH referred to two European tertiary paediatric surgical centres over 11 years (January 1999 to December 2009). Minimum follow-up was 1 year. χ(2) test for trend was used to evaluate significance. RESULTS: There were 234 infants. There was no significant variation over time in the proportion of infants receiving high frequency oscillatory ventilation (HFOV) (p = 0.89), inhaled nitric oxide (iNO) (p = 0.90) or extracorporeal membrane oxygenation (ECMO) (p = 0.22). 205 infants (88 %) were stabilised and underwent surgical repair; of these, 186 (79 %) survived after surgery. Over time there was a significant increase in the proportion of infants undergoing surgical repair (p = 0.018) without a concomitant significant improvement in survival (p = 0.099). CONCLUSION: This multicentre analysis indicates that the survival rate of infants with CDH referred to two European paediatric surgical centres is high (79 %). The use of HFOV, iNO and ECMO has not changed in recent years. We observed a significant increase in the proportion of infants who undergo surgery but this has not resulted in a significant increase in the overall survival rate.
PURPOSE:Congenital diaphragmatic hernia (CDH) remains a challenging and life-threatening congenital anomaly. The aim was to evaluate whether treatment and survival has changed during the last decade. METHODS: We retrospectively analysed all consecutive infants with CDH referred to two European tertiary paediatric surgical centres over 11 years (January 1999 to December 2009). Minimum follow-up was 1 year. χ(2) test for trend was used to evaluate significance. RESULTS: There were 234 infants. There was no significant variation over time in the proportion of infants receiving high frequency oscillatory ventilation (HFOV) (p = 0.89), inhaled nitric oxide (iNO) (p = 0.90) or extracorporeal membrane oxygenation (ECMO) (p = 0.22). 205 infants (88 %) were stabilised and underwent surgical repair; of these, 186 (79 %) survived after surgery. Over time there was a significant increase in the proportion of infants undergoing surgical repair (p = 0.018) without a concomitant significant improvement in survival (p = 0.099). CONCLUSION: This multicentre analysis indicates that the survival rate of infants with CDH referred to two European paediatric surgical centres is high (79 %). The use of HFOV, iNO and ECMO has not changed in recent years. We observed a significant increase in the proportion of infants who undergo surgery but this has not resulted in a significant increase in the overall survival rate.
Authors: L Desfrere; P H Jarreau; M Dommergues; A Brunhes; P Hubert; C Nihoul-Fekete; P Mussat; G Moriette Journal: Intensive Care Med Date: 2000-07 Impact factor: 17.440
Authors: M N de la Hunt; N Madden; J E Scott; J N Matthews; J Beck; C Sadler; A M Barrett; S A Boddy; R J Bray; E Cusick; L Gardner; S A Hargrave; W Hinton; L Rangecroft; R Spicer; M Stafford; D Thomas; C J Vallis; J Wagget Journal: J Pediatr Surg Date: 1996-11 Impact factor: 2.545
Authors: Juan E Sola; Steven N Bronson; Michael C Cheung; Beatriz Ordonez; Holly L Neville; Leonidas G Koniaris Journal: J Pediatr Surg Date: 2010-06 Impact factor: 2.545
Authors: Christopher A Guidry; Tjasa Hranjec; Bradley M Rodgers; Bartholomew Kane; Eugene D McGahren Journal: J Am Coll Surg Date: 2012-02-28 Impact factor: 6.113
Authors: A Cacciari; G Ruggeri; M Mordenti; P L Ceccarelli; E Baccarini; A Pigna; A Gentili Journal: Eur J Pediatr Surg Date: 2001-02 Impact factor: 2.191
Authors: David W Kays; Saleem Islam; Douglas S Richards; Shawn D Larson; Joy M Perkins; James L Talbert Journal: J Am Coll Surg Date: 2014-02-07 Impact factor: 6.113
Authors: Johannes W Duess; Elke M Zani-Ruttenstock; Massimo Garriboli; Prem Puri; Agostino Pierro; Michael E Hoellwarth Journal: Pediatr Surg Int Date: 2015-03-24 Impact factor: 1.827
Authors: Christopher D Baker; Claudine P Black; Sharon L Ryan; Vivek Balasubramaniam; Steven H Abman Journal: J Pediatr Date: 2013-05-16 Impact factor: 4.406
Authors: Maria D Politis; Eva Bermejo-Sánchez; Mark A Canfield; Paolo Contiero; Janet D Cragan; Saeed Dastgiri; Hermien E K de Walle; Marcia L Feldkamp; Amy Nance; Boris Groisman; Miriam Gatt; Adriana Benavides-Lara; Paula Hurtado-Villa; Kärin Kallén; Danielle Landau; Nathalie Lelong; Jorge Lopez-Camelo; Laura Martinez; Margery Morgan; Osvaldo M Mutchinick; Anna Pierini; Anke Rissmann; Antonin Šípek; Elena Szabova; Wladimir Wertelecki; Ignacio Zarante; Marian K Bakker; Vijaya Kancherla; Pierpaolo Mastroiacovo; Wendy N Nembhard Journal: Ann Epidemiol Date: 2020-11-27 Impact factor: 3.797