Literature DB >> 23089701

Global DNA hypomethylation in cancer: review of validated methods and clinical significance.

Estela G Toraño1, Sandra Petrus, Agustin F Fernandez, Mario F Fraga.   

Abstract

Abstract DNA methylation is one of the best-known epigenetic modifications in mammals. The alteration of DNA methylation patterns has been found to be related to many diseases, including cancer. It is well-known that during carcinogenesis, a site-specific DNA hypermethylation and a global DNA hypomethylation take place. This overall loss of DNA methylation has been proposed as a valid biomarker for cancer. Given its medical utility, in recent years it has become apparent that there is a need to develop methods for the analysis of DNA methylation using different approaches: global, locus-specific, or genome-wide. Here we review some of these techniques and discuss their potential clinical utility.

Entities:  

Mesh：

Year:  2012        PMID： 23089701     DOI： 10.1515/cclm-2011-0902

Source DB:  PubMed          Journal:  Clin Chem Lab Med        ISSN： 1434-6621            Impact factor:   3.694


  34 in total

Review 1.  Aberrant DNA methylation in human cancers.

Authors:  Wen Li; Bi-Feng Chen
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2013-12-13

Review 2.  Basic mechanics of DNA methylation and the unique landscape of the DNA methylome in metal-induced carcinogenesis.

Authors:  Jason Brocato; Max Costa
Journal:  Crit Rev Toxicol       Date:  2013-07       Impact factor: 5.635

Review 3.  Epigenetic cancer prevention mechanisms in skin cancer.

Authors:  Kamalika Saha; Thomas J Hornyak; Richard L Eckert
Journal:  AAPS J       Date:  2013-08-01       Impact factor: 4.009

4.  Epigenome-wide DNA methylation landscape of melanoma progression to brain metastasis reveals aberrations on homeobox D cluster associated with prognosis.

Authors:  Diego M Marzese; Richard A Scolyer; Jamie L Huynh; Sharon K Huang; Hajime Hirose; Kelly K Chong; Eiji Kiyohara; Jinhua Wang; Neal P Kawas; Nicholas C Donovan; Keisuke Hata; James S Wilmott; Rajmohan Murali; Michael E Buckland; Brindha Shivalingam; John F Thompson; Donald L Morton; Daniel F Kelly; Dave S B Hoon
Journal:  Hum Mol Genet       Date:  2013-09-06       Impact factor: 6.150

Review 5.  Epigenetic biomarkers: Current strategies and future challenges for their use in the clinical laboratory.

Authors:  José Luis García-Giménez; Marta Seco-Cervera; Trygve O Tollefsbol; Carlos Romá-Mateo; Lorena Peiró-Chova; Pablo Lapunzina; Federico V Pallardó
Journal:  Crit Rev Clin Lab Sci       Date:  2017-12-11       Impact factor: 6.250

6.  Dietary Ingestion of Calories and Micronutrients Modulates the DNA Methylation Profile of Leukocytes from Older Individuals.

Authors:  J Passador; L V Toffoli; K B Fernandes; R D Neves-Souza; G G Pelosi; M V Gomes
Journal:  J Nutr Health Aging       Date:  2018       Impact factor: 4.075

Review 7.  Research status and funding trends of lung cancer biomarkers.

Authors:  Cui Li; Wei Hong
Journal:  J Thorac Dis       Date:  2013-10       Impact factor: 2.895

8.  Combined analysis of DNA methylation and cell cycle in cancer cells.

Authors:  Cécile Desjobert; Mounir El Maï; Tom Gérard-Hirne; Dominique Guianvarc'h; Arnaud Carrier; Cyrielle Pottier; Paola B Arimondo; Joëlle Riond
Journal:  Epigenetics       Date:  2015-01-23       Impact factor: 4.528

9.  Prospective study of DNA methylation at LINE-1 and Alu in peripheral blood and the risk of prostate cancer.

Authors:  Kathryn Hughes Barry; Lee E Moore; Linda M Liao; Wen-Yi Huang; Gabriella Andreotti; Matthew Poulin; Sonja I Berndt
Journal:  Prostate       Date:  2015-08-07       Impact factor: 4.104

10.  DNA methylation and histone modifications of Wnt genes by genistein during colon cancer development.

Authors:  Yukun Zhang; Qian Li; Hong Chen
Journal:  Carcinogenesis       Date:  2013-04-18       Impact factor: 4.944
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.