Literature DB >> 23087714

Antifracture drugs consumption in Tuscany Region before the Target Project: a valuable model for the analysis of administrative database.

Prisco Piscitelli1, Simone Parri, Maria Luisa Brandi.   

Abstract

OBJECTIVES: As the Target Project of Tuscany Region is aimed to identify significant changes occurring during the time of the project compared to the previous years, we have analyzed antifracture drugs consumption in the years immediately preceding the start-up of the program.
METHODS: We have analyzed the regional administrative database to search for antifracture drugs delivered by the regional healthcare system to people living in Tuscany in the year 2009. Both drugs directly distributed by hospitals or local health authorities (direct distribution dataset, FED), and those delivered through pharmacies (pharmaceutical distribution dataset, SPF) were included in the analysis. Private expenditures were indirectly computed because total pharmaceutical expenditures were also known. A specific subgroup analysis has been carried out on elderly patients with femoral fractures (years 2006-2010), which represent the population of Target Project, in order to assess the evolution of all antifracture drug prescriptions before the start up of the project.
RESULTS: A total of 690,768 boxes of antifracture drugs (20 million defined daily doses, DDD) have been delivered in year 2009 for total expenditures of 23 million Euros. Public expenditures accounted for 71% of the total (16 million; 6% of regional pharmaceutical expenditures). Alendronate and risedronate were the most used drugs. The number of antifracture medications prescribed within the first 90 days to elderly people with hip fractures increased in the period before the start-up of the Target project but they remained under 14%.
CONCLUSIONS: There is the need for an appropriate management of antifracture therapies, as they represent a valuable proportion of pharmaceutical expenditures. This need is pointed out also by the remarkable amount of direct private expenditures and by the few number of hip fractured people starting a treatment.

Entities:  

Keywords:  antifracture drugs; osteoporosis; private expenditures; public expenditures

Year:  2012        PMID: 23087714      PMCID: PMC3476521     

Source DB:  PubMed          Journal:  Clin Cases Miner Bone Metab        ISSN: 1724-8914


  14 in total

1.  The effect of age and bone mineral density on the absolute, excess, and relative risk of fracture in postmenopausal women aged 50-99: results from the National Osteoporosis Risk Assessment (NORA).

Authors:  E S Siris; S K Brenneman; E Barrett-Connor; P D Miller; S Sajjan; M L Berger; Y-T Chen
Journal:  Osteoporos Int       Date:  2006-01-04       Impact factor: 4.507

2.  Prediction of hip fracture risk by quantitative ultrasound in more than 7000 Swiss women > or =70 years of age: comparison of three technologically different bone ultrasound devices in the SEMOF study.

Authors:  Marc-Antoine Krieg; Jacques Cornuz; Christiane Ruffieux; Guy Van Melle; Daniel Büche; Maximilian A Dambacher; Didier Hans; Florian Hartl; Hansjorg J Häuselmann; Marius Kraenzlin; Kurt Lippuner; Maurus Neff; Pierro Pancaldi; Rene Rizzoli; Franco Tanzi; Robert Theiler; Alan Tyndall; Claus Wimpfheimer; Peter Burckhardt
Journal:  J Bone Miner Res       Date:  2006-09       Impact factor: 6.741

3.  Incidence and costs of hip fractures compared to acute myocardial infarction in the Italian population: a 4-year survey.

Authors:  P Piscitelli; G Iolascon; F Gimigliano; M Muratore; P Camboa; O Borgia; B Forcina; F Fitto; V Robaud; G Termini; G B Rini; E Gianicolo; A Faino; M Rossini; S Adami; A Angeli; A Distante; S Gatto; R Gimigliano; G Guida
Journal:  Osteoporos Int       Date:  2006-10-24       Impact factor: 4.507

4.  Quantitative heel ultrasound in a population-based study in Italy and its relationship with fracture history: the ESOPO study.

Authors:  S Maggi; M Noale; S Giannini; S Adami; D Defeo; G Isaia; L Sinigaglia; P Filipponi; G Crepaldi
Journal:  Osteoporos Int       Date:  2005-09-02       Impact factor: 4.507

5.  [Incidence and socioeconomic burden of hip fractures in Italy: extension study 2003-2005].

Authors:  P Piscitelli; M L Brandi; U Tarantino; A Baggiani; A Distante; M Muratore; V Grattagliano; A Migliore; M Granata; G Guglielmi; R Gimigliano; G Iolascon
Journal:  Reumatismo       Date:  2010 Apr-Jun

6.  Pharmaco-economic issues in the treatment of severe osteoporosis.

Authors:  Prisco Piscitelli; Giovanna Chitano; Marco Greco; Marco Benvenuto; Enzo Sbenaglia; Giuseppe Colì; Alberto Migliore; Mauro Granata; Giovanni Iolascon; Raffaele Gimigliano; Angelo Baggiani; Alessandro Distante; Umberto Tarantino; Carla Rizzuti; Maria Luisa Brandi
Journal:  Clin Cases Miner Bone Metab       Date:  2010-01

7.  Epidemiology of fragility fractures in Italy.

Authors:  Prisco Piscitelli; Maria Luisa Brandi; Giovanna Chitano; Alberto Argentiero; Cosimo Neglia; Alessandro Distante; Luca Saturnino; Umberto Tarantino
Journal:  Clin Cases Miner Bone Metab       Date:  2011-05

8.  The effect of age, weight, and lifestyle factors on calcaneal quantitative ultrasound: the ESOPO study.

Authors:  Silvano Adami; Sandro Giannini; Ruben Giorgino; GianCarlo Isaia; Stefania Maggi; Luigi Sinigaglia; Paolo Filipponi; Gaetano Crepaldi; Ombretta Di Munno
Journal:  Osteoporos Int       Date:  2003-04-11       Impact factor: 4.507

9.  The incidence of hip, forearm, humeral, ankle, and vertebral fragility fractures in Italy: results from a 3-year multicenter study.

Authors:  Umberto Tarantino; Antonio Capone; Marco Planta; Michele D'Arienzo; Giulia Letizia Mauro; Angelo Impagliazzo; Alessandro Formica; Francesco Pallotta; Vittorio Patella; Antonio Spinarelli; Ugo Pazzaglia; Guido Zarattini; Mauro Roselli; Giuseppina Montanari; Giuseppe Sessa; Marco Privitera; Cesare Verdoia; Costantino Corradini; Maurizio Feola; Antonio Padolino; Luca Saturnino; Alessandro Scialdoni; Cecilia Rao; Giovanni Iolascon; Maria Luisa Brandi; Prisco Piscitelli
Journal:  Arthritis Res Ther       Date:  2010-12-29       Impact factor: 5.156

Review 10.  European guidance for the diagnosis and management of osteoporosis in postmenopausal women.

Authors:  J A Kanis; N Burlet; C Cooper; P D Delmas; J-Y Reginster; F Borgstrom; R Rizzoli
Journal:  Osteoporos Int       Date:  2008-02-12       Impact factor: 4.507

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  3 in total

1.  The T.A.R.Ge.T. project: a regional program to reduce hip fracture in elderly patients. Main results of retrospective phase.

Authors:  Simone Parri; Luisella Cianferotti; Gemma Marcucci; Giorgio Gronchi; Carla Rizzuti; Emanuela Colli; Beatrice Manetti; Walter Naldoni; Maria Luisa Brandi
Journal:  Clin Cases Miner Bone Metab       Date:  2015 Jan-Apr

Review 2.  The role of the orthopaedic surgeon in the prevention of refracture in patients treated surgically for fragility hip and vertebral fracture.

Authors:  Rosella Beraldi; Laura Masi; Simone Parri; Raffaele Partescano; Maria Luisa Brandi
Journal:  Clin Cases Miner Bone Metab       Date:  2014-01

3.  Evaluation of fracture risk and fracture prevention: an Italian picture.

Authors:  Maria Luisa Brandi
Journal:  Clin Cases Miner Bone Metab       Date:  2012-09-30
  3 in total

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