Mark A Smith1, Elizabeth G Pitts. 1. Department of Psychology, Davidson College, Davidson, NC 28035, USA. masmith@davidson.edu
Abstract
BACKGROUND: The purpose of this study was to examine the effects of voluntary wheel running on the positive reinforcing effects of heroin in rats with an established history of drug self-administration. METHODS: Rats were assigned to sedentary (no wheel) and exercise (wheel) conditions and trained to self-administer cocaine under positive reinforcement contingencies. Rats acquiring cocaine self-administration were then tested with various doses of heroin during daily test sessions. RESULTS: Sedentary rats self-administered more heroin than exercising rats, and this effect was greatest at low and moderate doses of heroin. CONCLUSION: These data suggest that voluntary wheel running decreases the positive reinforcing effects of heroin.
BACKGROUND: The purpose of this study was to examine the effects of voluntary wheel running on the positive reinforcing effects of heroin in rats with an established history of drug self-administration. METHODS:Rats were assigned to sedentary (no wheel) and exercise (wheel) conditions and trained to self-administer cocaine under positive reinforcement contingencies. Rats acquiring cocaine self-administration were then tested with various doses of heroin during daily test sessions. RESULTS: Sedentary rats self-administered more heroin than exercising rats, and this effect was greatest at low and moderate doses of heroin. CONCLUSION: These data suggest that voluntary wheel running decreases the positive reinforcing effects of heroin.
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