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Literature DB >> 23084354

The taming of the NF-κB: PP4R1 navigates while PP4c dephosphorylates.

Abstract

The NF-κB signaling pathway is important in the regulation of physiological and malignant hematopoiesis. In this issue of Immunity, Brechmann et al. (2012) identify a phosphatase, PP4R1, that inhibits NF-κB activation in T cells and T cell lymphoma.

Entities: Chemical

Year: 2012 PMID： 23084354 PMCID： PMC3493159 DOI： 10.1016/j.immuni.2012.10.006

Source DB: PubMed Journal: Immunity ISSN： 1074-7613 Impact factor: 31.745

9 in total

Review 1. NF-κB, the first quarter-century: remarkable progress and outstanding questions.

Authors: Matthew S Hayden; Sankar Ghosh
Journal: Genes Dev Date: 2012-02-01 Impact factor: 11.361

Review 2. Evolving insights in the pathogenesis and therapy of cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).

Authors: Henry K Wong; Anjali Mishra; Timothy Hake; Pierluigi Porcu
Journal: Br J Haematol Date: 2011-08-25 Impact factor: 6.998

Review 3. Regulation and function of IKK and IKK-related kinases.

Authors: Hans Häcker; Michael Karin
Journal: Sci STKE Date: 2006-10-17

Review 4. Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies.

Authors: Kian-Huat Lim; Yibin Yang; Louis M Staudt
Journal: Immunol Rev Date: 2012-03 Impact factor: 12.988

5. Down-regulating constitutive activation of the NF-kappaB canonical pathway overcomes the resistance of cutaneous T-cell lymphoma to apoptosis.

Authors: Aurore Sors; Francette Jean-Louis; Claire Pellet; Liliane Laroche; Louis Dubertret; Gilles Courtois; Hervé Bachelez; Laurence Michel
Journal: Blood Date: 2005-10-11 Impact factor: 22.113

1 in total

1. Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.

Authors: Jocelyn A Lee; Zhengqi Wang; Danielle Sambo; Kevin D Bunting; David C Pallas
Journal: J Biol Chem Date: 2018-05-07 Impact factor: 5.157

1 in total

The taming of the NF-κB: PP4R1 navigates while PP4c dephosphorylates.

Review 1. NF-κB, the first quarter-century: remarkable progress and outstanding questions.

Review 2. Evolving insights in the pathogenesis and therapy of cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).

Review 3. Regulation and function of IKK and IKK-related kinases.

Review 4. Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies.

5. Down-regulating constitutive activation of the NF-kappaB canonical pathway overcomes the resistance of cutaneous T-cell lymphoma to apoptosis.

Review 6. Inhibitory kappa B Kinases as targets for pharmacological regulation.

7. A PP4 phosphatase complex dephosphorylates RPA2 to facilitate DNA repair via homologous recombination.

8. Purification and identification of a novel subunit of protein serine/threonine phosphatase 4.

9. Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1.

1. Global loss of leucine carboxyl methyltransferase-1 causes severe defects in fetal liver hematopoiesis.