Literature DB >> 23082895

A drug fatality involving Kratom.

Michael F Neerman1, Randall E Frost, Janine Deking.   

Abstract

A 17-year-old white man who showed no obvious signs of trauma was found unresponsive in bed and was pronounced dead at the scene. The decedent had a documented history of heroin abuse and chronic back pain and reportedly self-medicated with Kratom (mitragynine). The autopsy was remarkable only for pulmonary congestion and edema and a distended bladder, both of which are consistent with, though not diagnostic of, opiate use. A laboratory work-up revealed therapeutic levels of over-the-counter cold medications and benzodiazepines. However, of interest was a level of mitragynine at 0.60 mg/L. Given the facts of the case, the Medical Examiner certified the cause of death as "possible Kratom toxicity" and the manner of death was classified as "accident."
© 2012 American Academy of Forensic Sciences.

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Year:  2012        PMID: 23082895     DOI: 10.1111/1556-4029.12009

Source DB:  PubMed          Journal:  J Forensic Sci        ISSN: 0022-1198            Impact factor:   1.832


  23 in total

Review 1.  The pharmacology and toxicology of kratom: from traditional herb to drug of abuse.

Authors:  Marcus L Warner; Nellie C Kaufman; Oliver Grundmann
Journal:  Int J Legal Med       Date:  2015-10-28       Impact factor: 2.686

2.  Novel case of maternal and neonatal kratom dependence and withdrawal.

Authors:  Lindsay Mackay; Ronald Abrahams
Journal:  Can Fam Physician       Date:  2018-02       Impact factor: 3.275

3.  Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit β-Arrestin-2.

Authors:  András Váradi; Gina F Marrone; Travis C Palmer; Ankita Narayan; Márton R Szabó; Valerie Le Rouzic; Steven G Grinnell; Joan J Subrath; Evelyn Warner; Sanjay Kalra; Amanda Hunkele; Jeremy Pagirsky; Shainnel O Eans; Jessica M Medina; Jin Xu; Ying-Xian Pan; Attila Borics; Gavril W Pasternak; Jay P McLaughlin; Susruta Majumdar
Journal:  J Med Chem       Date:  2016-09-02       Impact factor: 7.446

4.  The inhibitory effects of mitragynine on P-glycoprotein in vitro.

Authors:  Noradliyanti Rusli; Azimah Amanah; Gurjeet Kaur; Mohd Ilham Adenan; Shaida Fariza Sulaiman; Habibah Abdul Wahab; Mei Lan Tan
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2019-01-02       Impact factor: 3.000

5.  Bioanalytical method development and validation of corynantheidine, a kratom alkaloid, using UPLC-MS/MS, and its application to preclinical pharmacokinetic studies.

Authors:  Tamara I King; Abhisheak Sharma; Shyam H Kamble; Francisco León; Erin C Berthold; Raluca Popa; Orélia Cerlati; Boone M Prentice; Lance R McMahon; Christopher R McCurdy; Bonnie A Avery
Journal:  J Pharm Biomed Anal       Date:  2019-12-05       Impact factor: 3.935

6.  Pharmacokinetics of mitragynine in man.

Authors:  Satariya Trakulsrichai; Korbtham Sathirakul; Saranya Auparakkitanon; Jatupon Krongvorakul; Jetjamnong Sueajai; Nantida Noumjad; Chonlaphat Sukasem; Winai Wananukul
Journal:  Drug Des Devel Ther       Date:  2015-04-29       Impact factor: 4.162

7.  Evaluation of the cardiotoxicity of mitragynine and its analogues using human induced pluripotent stem cell-derived cardiomyocytes.

Authors:  Jun Lu; Heming Wei; Jianjun Wu; Mohd Fadzly Amar Jamil; Mei Lan Tan; Mohd Ilham Adenan; Philip Wong; Winston Shim
Journal:  PLoS One       Date:  2014-12-23       Impact factor: 3.240

Review 8.  Hepatotoxicity Induced by "the 3Ks": Kava, Kratom and Khat.

Authors:  Flaminia Pantano; Roberta Tittarelli; Giulio Mannocchi; Simona Zaami; Serafino Ricci; Raffaele Giorgetti; Daniela Terranova; Francesco P Busardò; Enrico Marinelli
Journal:  Int J Mol Sci       Date:  2016-04-16       Impact factor: 5.923

9.  Suspected Adulteration of Commercial Kratom Products with 7-Hydroxymitragynine.

Authors:  Alicia G Lydecker; Abhisheak Sharma; Christopher R McCurdy; Bonnie A Avery; Kavita M Babu; Edward W Boyer
Journal:  J Med Toxicol       Date:  2016-10-17

Review 10.  Following "the Roots" of Kratom (Mitragyna speciosa): The Evolution of an Enhancer from a Traditional Use to Increase Work and Productivity in Southeast Asia to a Recreational Psychoactive Drug in Western Countries.

Authors:  Eduardo Cinosi; Giovanni Martinotti; Pierluigi Simonato; Darshan Singh; Zsolt Demetrovics; Andres Roman-Urrestarazu; Francesco Saverio Bersani; Balasingam Vicknasingam; Giulia Piazzon; Jih-Heng Li; Wen-Jing Yu; Máté Kapitány-Fövény; Judit Farkas; Massimo Di Giannantonio; Ornella Corazza
Journal:  Biomed Res Int       Date:  2015-11-10       Impact factor: 3.411

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