Literature DB >> 23079862

Graphene oxide strongly inhibits amyloid beta fibrillation.

Morteza Mahmoudi1, Omid Akhavan, Mahdi Ghavami, Farhad Rezaee, Seyyed Mohammad Amin Ghiasi.   

Abstract

UNLABELLED: Since amyloid beta fibrillation (AβF) plays an important role in the development of neurodegenerative diseases, we investigated the effect of graphene oxide (GO) and their protein-coated surfaces on the kinetics of Aβ fibrillation in the aqueous solution. We showed that GO and their protein-covered surfaces delay the AβF process via adsorption of amyloid monomers. Also, the large available surface of GO sheets can delay the AβF process by adsorption of amyloid monomers. The inhibitory effect of the GO sheet was increased when we increase the concentration from 10% (in vitro; stimulated media) to 100% (in vivo; stimulated media).
CONCLUSION: our results revealed that GO and their surface proteins inhibit AβF by decreasing the kinetic reaction.

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Year:  2012        PMID： 23079862     DOI： 10.1039/c2nr31657a

Source DB:  PubMed          Journal:  Nanoscale        ISSN： 2040-3364            Impact factor:   7.790


  39 in total

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