Literature DB >> 23079566

Implications of alcohol intoxication at the time of burn and smoke inhalation injury: an epidemiologic and clinical analysis.

Christopher S Davis1, Thomas J Esposito, Anna G Palladino-Davis, Karen Rychlik, Carol R Schermer, Richard L Gamelli, Elizabeth J Kovacs.   

Abstract

Up to 50% of burn patient fatalities have a history of alcohol use, and for those surviving to hospitalization, alcohol intoxication may increase the risk of infection and mortality. Yet, the effect of binge drinking on burn patients, specifically those with inhalation injuries, is not well described. We aimed to investigate the epidemiology and outcomes of this select patient population. In a prospective study, 53 patients with an inhalation injury and a documented blood alcohol content (BAC) were grouped as BAC negative (n = 37), BAC = 1 to 79 mg/dl (n = 4), and BAC ≥ 80 mg/dl (n = 12). Those in the last group were designated as binge drinkers according to National Institute on Alcohol Abuse and Alcoholism criteria. Binge drinkers with an inhalation injury had considerably smaller %TBSA burns than did their nondrinking counterparts (mean %TBSA 10.6 vs 24.9; P = .065) and significantly lower revised Baux scores (mean 75.9 vs 94.9; P = .030). Despite binge drinkers having smaller injuries, the groups did not differ in terms of outcomes and resource utilization. Finally, those in the binge-drinking group had considerably higher carboxyhemoglobin levels (median 5.2 vs 23.0; P = .026) than did nondrinkers. Binge drinkers with inhalation injuries surviving to hospitalization had less severe injuries than did nondrinkers, although their outcomes and burden to the healthcare infrastructure were similar to the nondrinking patients. Our findings affirm the effect of alcohol intoxication at the time of burn and smoke inhalation injury, placing renewed emphasis on injury prevention and alcohol abuse education.

Entities:  

Mesh:

Year:  2013        PMID: 23079566      PMCID: PMC3540156          DOI: 10.1097/BCR.0b013e3182644c58

Source DB:  PubMed          Journal:  J Burn Care Res        ISSN: 1559-047X            Impact factor:   1.845


  38 in total

1.  Simplified estimates of the probability of death after burn injuries: extending and updating the baux score.

Authors:  Turner Osler; Laurent G Glance; David W Hosmer
Journal:  J Trauma       Date:  2010-03

2.  Inhalation injury, pulmonary perturbations, and fluid resuscitation.

Authors:  Frederick W Endorf; Richard L Gamelli
Journal:  J Burn Care Res       Date:  2007 Jan-Feb       Impact factor: 1.845

3.  The increasing trend in alcohol-related burns: it's impact on a tertiary burn centre.

Authors:  William J M Holmes; Phoebe Hold; Malcolm I James
Journal:  Burns       Date:  2010-02-24       Impact factor: 2.744

4.  Predictive role of arterial carboxyhemoglobin concentrations in ovine burn and smoke inhalation-induced lung injury.

Authors:  Matthias Lange; Robert A Cox; Perenlei Enkhbaatar; Elbert B Whorton; Yoshimitsu Nakano; Atsumori Hamahata; Collette Jonkam; Aimalohi Esechie; Sanna von Borzyskowski; Lillian D Traber; Daniel L Traber
Journal:  Exp Lung Res       Date:  2011-02-11       Impact factor: 2.459

5.  Alcohol, drug intoxication, or both at the time of burn injury as a predictor of complications and mortality in hospitalized patients with burns.

Authors:  S R Grobmyer; S P Maniscalco; G F Purdue; J L Hunt
Journal:  J Burn Care Rehabil       Date:  1996 Nov-Dec

6.  Adverse clinical outcomes associated with elevated blood alcohol levels at the time of burn injury.

Authors:  Geoffrey M Silver; Joslyn M Albright; Carol R Schermer; Marcia Halerz; Peggie Conrad; Paul D Ackerman; Linda Lau; Mary Ann Emanuele; Elizabeth J Kovacs; Richard L Gamelli
Journal:  J Burn Care Res       Date:  2008 Sep-Oct       Impact factor: 1.845

Review 7.  Alcohol, injury, and cellular immunity.

Authors:  Kelly A Nordyke Messingham; Douglas E Faunce; Elizabeth J Kovacs
Journal:  Alcohol       Date:  2002-11       Impact factor: 2.405

8.  Acute ethanol exposure attenuates pattern recognition receptor activated macrophage functions.

Authors:  John Karavitis; Eva L Murdoch; Christian R Gomez; Luis Ramirez; Elizabeth J Kovacs
Journal:  J Interferon Cytokine Res       Date:  2008-07       Impact factor: 2.607

9.  Implications of formal alcohol screening in burn patients.

Authors:  Joslyn M Albright; Elizabeth J Kovacs; Richard L Gamelli; Carol R Schermer
Journal:  J Burn Care Res       Date:  2009 Jan-Feb       Impact factor: 1.845

10.  The effects of preexisting medical comorbidities on mortality and length of hospital stay in acute burn injury: evidence from a national sample of 31,338 adult patients.

Authors:  Brett D Thombs; Vijay A Singh; Jill Halonen; Alfa Diallo; Stephen M Milner
Journal:  Ann Surg       Date:  2007-04       Impact factor: 12.969

View more
  21 in total

1.  6-Formylindolo (3, 2-b) Carbazole (FICZ)-mediated protection of gut barrier is dependent on T cells in a mouse model of alcohol combined with burn injury.

Authors:  Xiaoling Li; Marisa E Luck; Adam M Hammer; Abigail R Cannon; Mashkoor A Choudhry
Journal:  Biochim Biophys Acta Mol Basis Dis       Date:  2020-07-22       Impact factor: 5.187

2.  Enhanced Platelet-Activating Factor Synthesis Facilitates Acute and Delayed Effects of Ethanol-Intoxicated Thermal Burn Injury.

Authors:  Kathleen A Harrison; Eric Romer; Jonathan Weyerbacher; Jesus A Ocana; Ravi P Sahu; Robert C Murphy; Lisa E Kelly; Townsend A Smith; Christine M Rapp; Christina Borchers; David R Cool; Gengxin Li; Richard Simman; Jeffrey B Travers
Journal:  J Invest Dermatol       Date:  2018-05-30       Impact factor: 8.551

3.  Mesenchymal stem cell treatment attenuates liver and lung inflammation after ethanol intoxication and burn injury.

Authors:  Brenda J Curtis; Jill A Shults; Devin M Boe; Luis Ramirez; Elizabeth J Kovacs
Journal:  Alcohol       Date:  2018-09-11       Impact factor: 2.405

4.  The influence of substance misuse on clinical outcomes following burn.

Authors:  Sarah Rehou; Stephanie Mason; Jessie MacDonald; Ruxandra Pinto; Marc G Jeschke
Journal:  Burns       Date:  2017-05-12       Impact factor: 2.744

5.  Alcohol Intoxication and the Postburn Gastrointestinal Hormonal Response.

Authors:  Juan-Pablo Idrovo; Jill A Shults; Brenda J Curtis; Michael M Chen; Elizabeth J Kovacs
Journal:  J Burn Care Res       Date:  2019-10-16       Impact factor: 1.845

6.  Kupffer Cell p38 Mitogen-Activated Protein Kinase Signaling Drives Postburn Hepatic Damage and Pulmonary Inflammation When Alcohol Intoxication Precedes Burn Injury.

Authors:  Michael M Chen; Eileen B O'Halloran; Jill A Shults; Elizabeth J Kovacs
Journal:  Crit Care Med       Date:  2016-10       Impact factor: 7.598

7.  The Effect of Illicit Drug Use on Outcomes Following Burn Injury.

Authors:  Erica I Hodgman; Madhu Subramanian; Steven E Wolf; Brett D Arnoldo; Herb A Phelan; Michael W Cripps; Kareem R Abdel Fattah
Journal:  J Burn Care Res       Date:  2017 Jan/Feb       Impact factor: 1.845

8.  Dosage scaling of alcohol in binge exposure models in mice: An empirical assessment of the relationship between dose, alcohol exposure, and peak blood concentrations in humans and mice.

Authors:  Stephen Pruett; Wei Tan; George E Howell; Bindu Nanduri
Journal:  Alcohol       Date:  2020-04-04       Impact factor: 2.405

9.  The association of injury with substance use disorder among women of reproductive age: an opportunity to address a major contributor to recurrent preventable emergency department visits?

Authors:  Judith Bernstein; Edward Bernstein; Candice Belanoff; Howard J Cabral; Hermik Babakhanlou-Chase; Taletha M Derrington; Hafsatou Diop; Carole Douriez; Stephen R Evans; Hilary Jacobs; Milton Kotelchuck
Journal:  Acad Emerg Med       Date:  2014-12       Impact factor: 3.451

10.  Bias in alcohol and drug screening in adult burn patients.

Authors:  Felicia N Williams; Lori Chrisco; Paula D Strassle; Sarah L Laughon; Sanja Sljivic; Kamil Nurczyk; Rabia Nizamani; Booker T King; Anthony Charles
Journal:  Int J Burns Trauma       Date:  2020-08-15
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.