| Literature DB >> 23078294 |
Qiu-Fen Hu1, Bin Zhou, Xue-Mei Gao, Li-Ying Yang, Li-Dan Shu, Yanqiong Shen, Gan-Peng Li, Chun-Tao Che, Guang-Yu Yang.
Abstract
Seven new chromones, siamchromones A-G (1-7), and 12 known chromones (8-19) were isolated from the stems of Cassia siamea. Compounds 1-19 were evaluated for their antitobacco mosaic virus (anti-TMV) and anti-HIV-1 activities. Compound 6 showed antitobacco mosaic virus (anti-TMV) activity with an inhibition rate of 35.3% and IC50 value of 31.2 μM, which is higher than that of the positive control, ningnamycin. Compounds 1, 10, 13, and 16 showed anti-TMV activities with inhibition rates above 10%. Compounds 4, 6, 13, and 19 showed anti-HIV-1 activities with therapeutic index values above 50.Entities:
Mesh：
Substances：
Year: 2012 PMID： 23078294 DOI： 10.1021/np300395m
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050