Literature DB >> 23076065

Stopping a chromatin enzyme.

Jeffrey A Simon.   

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Year:  2012        PMID: 23076065     DOI: 10.1038/nchembio.1088

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN: 1552-4450            Impact factor:   15.040


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  11 in total

1.  Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas.

Authors:  Christopher J Sneeringer; Margaret Porter Scott; Kevin W Kuntz; Sarah K Knutson; Roy M Pollock; Victoria M Richon; Robert A Copeland
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-15       Impact factor: 11.205

Review 2.  Protein methyltransferases as a target class for drug discovery.

Authors:  Robert A Copeland; Michael E Solomon; Victoria M Richon
Journal:  Nat Rev Drug Discov       Date:  2009-09       Impact factor: 84.694

3.  Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation.

Authors:  Wen Yuan; Tong Wu; Hang Fu; Chao Dai; Hui Wu; Nan Liu; Xiang Li; Mo Xu; Zhuqiang Zhang; Tianhui Niu; Zhifu Han; Jijie Chai; Xianghong Jasmine Zhou; Shaorong Gao; Bing Zhu
Journal:  Science       Date:  2012-08-24       Impact factor: 47.728

4.  A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.

Authors:  Sarah K Knutson; Tim J Wigle; Natalie M Warholic; Christopher J Sneeringer; Christina J Allain; Christine R Klaus; Joelle D Sacks; Alejandra Raimondi; Christina R Majer; Jeffrey Song; Margaret Porter Scott; Lei Jin; Jesse J Smith; Edward J Olhava; Richard Chesworth; Mikel P Moyer; Victoria M Richon; Robert A Copeland; Heike Keilhack; Roy M Pollock; Kevin W Kuntz
Journal:  Nat Chem Biol       Date:  2012-09-30       Impact factor: 15.040

5.  Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells.

Authors:  Jing Tan; Xiaojing Yang; Li Zhuang; Xia Jiang; Wei Chen; Puay Leng Lee; R K Murthy Karuturi; Patrick Boon Ooi Tan; Edison T Liu; Qiang Yu
Journal:  Genes Dev       Date:  2007-04-16       Impact factor: 11.361

6.  Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27).

Authors:  Michael T McCabe; Alan P Graves; Gopinath Ganji; Elsie Diaz; Wendy S Halsey; Yong Jiang; Kimberly N Smitheman; Heidi M Ott; Melissa B Pappalardi; Kimberly E Allen; Stephanie B Chen; Anthony Della Pietra; Edward Dul; Ashley M Hughes; Seth A Gilbert; Sara H Thrall; Peter J Tummino; Ryan G Kruger; Martin Brandt; Benjamin Schwartz; Caretha L Creasy
Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-08       Impact factor: 11.205

7.  Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity.

Authors:  James Tsai; John T Lee; Weiru Wang; Jiazhong Zhang; Hanna Cho; Shumeye Mamo; Ryan Bremer; Sam Gillette; Jun Kong; Nikolas K Haass; Katrin Sproesser; Ling Li; Keiran S M Smalley; Daniel Fong; Yong-Liang Zhu; Adhirai Marimuthu; Hoa Nguyen; Billy Lam; Jennifer Liu; Ivana Cheung; Julie Rice; Yoshihisa Suzuki; Catherine Luu; Calvin Settachatgul; Rafe Shellooe; John Cantwell; Sung-Hou Kim; Joseph Schlessinger; Kam Y J Zhang; Brian L West; Ben Powell; Gaston Habets; Chao Zhang; Prabha N Ibrahim; Peter Hirth; Dean R Artis; Meenhard Herlyn; Gideon Bollag
Journal:  Proc Natl Acad Sci U S A       Date:  2008-02-19       Impact factor: 11.205

Review 8.  Roles of the EZH2 histone methyltransferase in cancer epigenetics.

Authors:  Jeffrey A Simon; Carol A Lange
Journal:  Mutat Res       Date:  2008-08-03       Impact factor: 2.433

Review 9.  The Polycomb complex PRC2 and its mark in life.

Authors:  Raphaël Margueron; Danny Reinberg
Journal:  Nature       Date:  2011-01-20       Impact factor: 49.962

10.  Role of the polycomb protein EED in the propagation of repressive histone marks.

Authors:  Raphael Margueron; Neil Justin; Katsuhito Ohno; Miriam L Sharpe; Jinsook Son; William J Drury; Philipp Voigt; Stephen R Martin; William R Taylor; Valeria De Marco; Vincenzo Pirrotta; Danny Reinberg; Steven J Gamblin
Journal:  Nature       Date:  2009-09-20       Impact factor: 49.962

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  4 in total

1.  Discovery of EBI-2511: A Highly Potent and Orally Active EZH2 Inhibitor for the Treatment of Non-Hodgkin's Lymphoma.

Authors:  Biao Lu; Xiaodong Shen; Lei Zhang; Dong Liu; Caihua Zhang; Jingsong Cao; Ru Shen; Jiayin Zhang; Dan Wang; Hong Wan; Zhibin Xu; Ming-Hsun Ho; Minsheng Zhang; Lianshan Zhang; Feng He; Weikang Tao
Journal:  ACS Med Chem Lett       Date:  2018-01-29       Impact factor: 4.345

Review 2.  The dynamics of HCF-1 modulation of herpes simplex virus chromatin during initiation of infection.

Authors:  Jodi L Vogel; Thomas M Kristie
Journal:  Viruses       Date:  2013-05-22       Impact factor: 5.048

3.  S-Adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells.

Authors:  Tsang-Pai Liu; Hsiang-Ling Lo; Li-Shan Wei; Heidi Hao-yun Hsiao; Pei-Ming Yang
Journal:  Anticancer Drugs       Date:  2015-02       Impact factor: 2.248

4.  Incorporating genomic, transcriptomic and clinical data: a prognostic and stem cell-like MYC and PRC imbalance in high-risk neuroblastoma.

Authors:  Xinan Holly Yang; Fangming Tang; Jisu Shin; John M Cunningham
Journal:  BMC Syst Biol       Date:  2017-10-03
  4 in total

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