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Literature DB >> 23076048

Molecular insights on context-specific role of profilin-1 in cell migration.

Abstract

Profilin-1 (Pfn1) is a ubiquitously expressed actin-monomer binding protein that has been linked to many cellular activities ranging from control of actin polymerization to gene transcription. Traditionally, Pfn1 has been considered to be an essential control element for actin polymerization and cell migration. Seemingly contrasting this view, a few recent studies have shown evidence of an inhibitory action of Pfn1 on motility of certain types of carcinoma cells. In this review, we summarize biochemistry and functional aspects of Pfn1 in normal cells and bring in newly emerged action of Pfn1 in cancer cells that may explain its context-specific role in cell migration.

Entities: Disease Gene

Mesh：

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Year: 2012 PMID： 23076048 PMCID： PMC3496682 DOI： 10.4161/cam.21832

Source DB: PubMed Journal: Cell Adh Migr ISSN： 1933-6918 Impact factor: 3.405

90 in total

1. Profilin binding to sub-micellar concentrations of phosphatidylinositol (4,5) bisphosphate and phosphatidylinositol (3,4,5) trisphosphate.

Authors: Pierre D J Moens; Luis A Bagatolli
Journal: Biochim Biophys Acta Date: 2006-12-23

2. In mouse brain profilin I and profilin II associate with regulators of the endocytic pathway and actin assembly.

Authors: W Witke; A V Podtelejnikov; A Di Nardo; J D Sutherland; C B Gurniak; C Dotti; M Mann
Journal: EMBO J Date: 1998-02-16 Impact factor: 11.598

3. Novel testis-expressed profilin IV associated with acrosome biogenesis and spermatid elongation.

Authors: Heike Obermann; Inka Raabe; Marga Balvers; Bärbel Brunswig; Wolfgang Schulze; Christiane Kirchhoff
Journal: Mol Hum Reprod Date: 2004-12-10 Impact factor: 4.025

4. Profilin 1 obtained by proteomic analysis in all-trans retinoic acid-treated hepatocarcinoma cell lines is involved in inhibition of cell proliferation and migration.

Authors: Nan Wu; Wen Zhang; Yong Yang; Yu-Long Liang; Li-Ying Wang; Jia-Wei Jin; Xiu-Mei Cai; Xi-Liang Zha
Journal: Proteomics Date: 2006-11 Impact factor: 3.984

5. Dynamic actin structures stabilized by profilin.

Authors: T Finkel; J A Theriot; K R Dise; G F Tomaselli; P J Goldschmidt-Clermont
Journal: Proc Natl Acad Sci U S A Date: 1994-02-15 Impact factor: 11.205

6. Signal-regulated activation of serum response factor is mediated by changes in actin dynamics.

Authors: A Sotiropoulos; D Gineitis; J Copeland; R Treisman
Journal: Cell Date: 1999-07-23 Impact factor: 41.582

7. Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells.

Authors: Yong Ho Bae; Zhijie Ding; Tuhin Das; Alan Wells; Frank Gertler; Partha Roy
Journal: Proc Natl Acad Sci U S A Date: 2010-11-29 Impact factor: 11.205

8. Exportin 6: a novel nuclear export receptor that is specific for profilin.actin complexes.

Authors: Theis Stüven; Enno Hartmann; Dirk Görlich
Journal: EMBO J Date: 2003-11-03 Impact factor: 11.598

9. Regulation of profilin localization in Saccharomyces cerevisiae by phosphoinositide metabolism.

Authors: D B Ostrander; J A Gorman; G M Carman
Journal: J Biol Chem Date: 1995-11-10 Impact factor: 5.157

10. Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors.

Authors: Evanthia T Roussos; Yarong Wang; Jeffrey B Wyckoff; Rani S Sellers; Weigang Wang; Jiufeng Li; Jeffrey W Pollard; Frank B Gertler; John S Condeelis
Journal: Breast Cancer Res Date: 2010-11-25 Impact factor: 6.466

34 in total

1. A four actin-binding protein signature model for poor prognosis of patients with esophageal squamous cell carcinoma.

Authors: Zhang-Mei Peng; Wei Yu; Ying Xie; Wei-Hua Peng; Hui-Hui Cao; Jin-Hui Shen; Zhi-Yong Wu; En-Min Li; Li-Yan Xu
Journal: Int J Clin Exp Pathol Date: 2014-08-15

Review 2. Profilin: many facets of a small protein.

Authors: Rhonda J Davey; Pierre Dj Moens
Journal: Biophys Rev Date: 2020-07-13

3. Actin-binding protein profilin1 promotes aggressiveness of clear-cell renal cell carcinoma cells.

Authors: Abigail Allen; David Gau; Paul Francoeur; Jordan Sturm; Yue Wang; Ryan Martin; Jodi Maranchie; Anette Duensing; Adam Kaczorowski; Stefan Duensing; Lily Wu; Michael T Lotze; David Koes; Walter J Storkus; Partha Roy
Journal: J Biol Chem Date: 2020-09-03 Impact factor: 5.157

4. Silencing profilin-1 inhibits gastric cancer progression via integrin β1/focal adhesion kinase pathway modulation.

Authors: Ya-Jun Cheng; Zhen-Xin Zhu; Jian-Sheng Zhou; Zun-Qi Hu; Jian-Peng Zhang; Qing-Ping Cai; Liang-Hua Wang
Journal: World J Gastroenterol Date: 2015-02-28 Impact factor: 5.742

5. Disruption of profilin1 function suppresses developmental and pathological retinal neovascularization.

Authors: David Gau; Lucile Vignaud; Abigail Allen; Zhijian Guo; Jose Sahel; David Boone; David Koes; Xavier Guillonneau; Partha Roy
Journal: J Biol Chem Date: 2020-05-22 Impact factor: 5.157

6. A balanced level of profilin-1 promotes stemness and tumor-initiating potential of breast cancer cells.

Authors: Chang Jiang; Zhijie Ding; Marion Joy; Souvik Chakraborty; Su Hyeong Kim; Ralph Bottcher; John Condeelis; Shivendra Singh; Partha Roy
Journal: Cell Cycle Date: 2017 Impact factor: 4.534

7. BRCA1 deficiency in ovarian cancer is associated with alteration in expression of several key regulators of cell motility - A proteomics study.

Authors: David M Gau; Jamie L Lesnock; Brian L Hood; Rohit Bhargava; Mai Sun; Kathleen Darcy; Soumya Luthra; Uma Chandran; Thomas P Conrads; Robert P Edwards; Joseph L Kelley; Thomas C Krivak; Partha Roy
Journal: Cell Cycle Date: 2015 Impact factor: 4.534