OBJECTIVE: To examine maternal insulin resistance in relationship with maternal and fetal androgen levels as well as with term placenta mRNA and protein abundance of steroidogenic enzymes implicated in androgen dynamics. METHODS: The study included 20 women with gestational diabetes mellitus and 27 controls tested using a 120 min., 75 g oral glucose tolerance test. Maternal and fetal plasma concentrations of total testosterone, dihydrotestosterone (DHT) and dehydroepiandrosterone (DHEA) were measured by high-performance gas chromatography and chemical ionization mass spectrometry at 26.1 ± 3.7 weeks of pregnancy. RESULTS: Glycemic response to oral glucose over 120 min. as well as Matsuda insulin sensitivity and HOMA insulin resistance (HOMA-IR) indices were significantly associated with maternal testosterone levels (r = 0.31, r = -0.37 and r = 0.35 respectively, p ≤ 0.05 for all). Among male offspring, a positive association between maternal and fetal testosterone levels was observed (r = 0.43, p ≤ 0.05). Testosterone levels were higher in the cord blood of newborns from insulin-resistant mothers compared to newborns from insulin-sensitive mothers (0.48 ± 0.36 nmol/L vs. 0.29 ± 0.18 nmol/L p ≤ 0.05). No difference was observed in mRNA abundance or protein expression of placental steroidogenic enzymes according to the degree of maternal insulin resistance. CONCLUSION: Our results demonstrate a possible association between fetal and maternal androgen concentrations in relationship with insulin resistance.
OBJECTIVE: To examine maternal insulin resistance in relationship with maternal and fetal androgen levels as well as with term placenta mRNA and protein abundance of steroidogenic enzymes implicated in androgen dynamics. METHODS: The study included 20 women with gestational diabetes mellitus and 27 controls tested using a 120 min., 75 g oral glucose tolerance test. Maternal and fetal plasma concentrations of total testosterone, dihydrotestosterone (DHT) and dehydroepiandrosterone (DHEA) were measured by high-performance gas chromatography and chemical ionization mass spectrometry at 26.1 ± 3.7 weeks of pregnancy. RESULTS: Glycemic response to oral glucose over 120 min. as well as Matsuda insulin sensitivity and HOMA insulin resistance (HOMA-IR) indices were significantly associated with maternal testosterone levels (r = 0.31, r = -0.37 and r = 0.35 respectively, p ≤ 0.05 for all). Among male offspring, a positive association between maternal and fetal testosterone levels was observed (r = 0.43, p ≤ 0.05). Testosterone levels were higher in the cord blood of newborns from insulin-resistant mothers compared to newborns from insulin-sensitive mothers (0.48 ± 0.36 nmol/L vs. 0.29 ± 0.18 nmol/L p ≤ 0.05). No difference was observed in mRNA abundance or protein expression of placental steroidogenic enzymes according to the degree of maternal insulin resistance. CONCLUSION: Our results demonstrate a possible association between fetal and maternal androgen concentrations in relationship with insulin resistance.
Authors: Vijayakumar Chinnathambi; Chellakkan S Blesson; Kathleen L Vincent; George R Saade; Gary D Hankins; Chandra Yallampalli; Kunju Sathishkumar Journal: Hypertension Date: 2014-05-19 Impact factor: 10.190
Authors: Kathirvel Gopalakrishnan; Jay S Mishra; Vijayakumar Chinnathambi; Kathleen L Vincent; Igor Patrikeev; Massoud Motamedi; George R Saade; Gary D Hankins; Kunju Sathishkumar Journal: Hypertension Date: 2016-01-18 Impact factor: 10.190
Authors: M Hill; A Pařízek; P Šimják; M Koucký; K Anderlová; H Krejčí; D Vejražková; L Ondřejíková; A Černý; R Kancheva Journal: Physiol Res Date: 2021-12-30 Impact factor: 2.139
Authors: Ran S Rotem; Gabriel Chodick; Michael Davidovitch; Russ Hauser; Brent A Coull; Marc G Weisskopf Journal: Am J Epidemiol Date: 2018-04-01 Impact factor: 4.897
Authors: Diana C Pacyga; Joseph C Gardiner; Jodi A Flaws; Zhong Li; Antonia M Calafat; Susan A Korrick; Susan L Schantz; Rita S Strakovsky Journal: Environ Int Date: 2021-06-08 Impact factor: 13.352