Literature DB >> 2307473

A primary linkage map of the human chromosome 11q22-23 region.

P Charmley1, T Foroud, S Wei, P Concannon, D E Weeks, K Lange, R A Gatti.   

Abstract

We have constructed a genetic map of the human chromosomal region 11q22-23 by multipoint linkage analysis of 13 DNA polymorphisms that we have condensed into eight loci. An analysis for linkage disequilibrium between tightly linked probe/enzyme systems allows us to make specific recommendations for future DNA typing at these loci. The resulting sex-averaged multipoint map spans approximately 80 cM and differs considerably from previously reported genetic maps of this region. Our mathematically derived "most likely order" of the markers is compatible with physical mapping data using somatic cell hybrids. The known localizations of at least 14 functional genes and several disease loci to 11q22-23, including ataxia telangiectasia, make the mapping of this region especially relevant to studies of disease pathogenesis.

Entities:  

Mesh：

Substances：

Year:  1990        PMID： 2307473     DOI： 10.1016/0888-7543(90)90572-c

Source DB:  PubMed          Journal:  Genomics        ISSN： 0888-7543            Impact factor:   5.736


  8 in total

1.  Further mapping of an ataxia-telangiectasia locus to the chromosome 11q23 region.

Authors:  O Sanal; S Wei; T Foroud; U Malhotra; P Concannon; P Charmley; W Salser; K Lange; R A Gatti
Journal:  Am J Hum Genet       Date:  1990-11       Impact factor: 11.025

2.  Highly informative dinucleotide repeat polymorphism at the D11S29 locus on chromosome 11q23.

Authors:  L Warnich; I Groenewald; L Theart; A E Retief
Journal:  Hum Genet       Date:  1992-05       Impact factor: 4.132

3.  Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

Authors:  S Ziemin-van der Poel; N R McCabe; H J Gill; R Espinosa; Y Patel; A Harden; P Rubinelli; S D Smith; M M LeBeau; J D Rowley
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-01       Impact factor: 11.205

Review 4.  A random walk method for computing genetic location scores.

Authors:  K Lange; E Sobel
Journal:  Am J Hum Genet       Date:  1991-12       Impact factor: 11.025

5.  Localization of an ataxia-telangiectasia locus to a 3-cM interval on chromosome 11q23: linkage analysis of 111 families by an international consortium.

Authors:  T Foroud; S Wei; Y Ziv; E Sobel; E Lange; A Chao; T Goradia; Y Huo; A Tolun; L Chessa; P Charmley; O Sanal; N Salman; C Julier; P Concannon; C McConville; A M Taylor; Y Shiloh; S K Lange; R A Gatti
Journal:  Am J Hum Genet       Date:  1991-12       Impact factor: 11.025

6.  Fine mapping of the chromosome 11q22-23 region using PFGE, linkage and haplotype analysis; localization of the gene for ataxia telangiectasia to a 5cM region flanked by NCAM/DRD2 and STMY/CJ52.75, phi 2.22.

Authors:  C M McConville; C J Formstone; D Hernandez; J Thick; A M Taylor
Journal:  Nucleic Acids Res       Date:  1990-08-11       Impact factor: 16.971

7.  Localization of an ataxia-telangiectasia gene to an approximately 500-kb interval on chromosome 11q23.1: linkage analysis of 176 families by an international consortium.

Authors:  E Lange; A L Borresen; X Chen; L Chessa; S Chiplunkar; P Concannon; S Dandekar; S Gerken; K Lange; T Liang
Journal:  Am J Hum Genet       Date:  1995-07       Impact factor: 11.025

8.  Analysis of 7 polymorphic markers at chromosome 11q22-23 in 35 ataxia telangiectasia families; further evidence of linkage.

Authors:  C M McConville; C G Woods; M Farrall; J A Metcalfe; A M Taylor
Journal:  Hum Genet       Date:  1990-07       Impact factor: 4.132
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.