Literature DB >> 2307459

Mitotic disturbance associated with mosaic aneuploidies.

K Miller1, W Müller, L Winkler, M R Hadam, J H Ehrich, S D Flatz.   

Abstract

The association of various unsystematic aneuploidies with premature centromere division (PCD) was observed in a patient with conspicuous clinical features and combined immunodeficiency. Trisomies and monosomies of almost all autosomes and gonosomal aberrations were found separately or in combination in a majority of the proband's lymphocytes and fibroblasts. The chromosome number varied from 44 to 50. A high proportion of the metaphases showed PCD or had the appearance of C-anaphases. These findings probably represent a new mutant affecting mitosis and causing mosaic aneuploidies.

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Year:  1990        PMID： 2307459     DOI： 10.1007/bf00196235

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  37 in total

1.  Parental centromere separation sequence and aneuploidy in the offspring.

Authors:  K Bajnóczky; K Méhes
Journal:  Hum Genet       Date:  1988-03       Impact factor: 4.132

2.  Centromere spreading and out-of-phase chromatid separation in Burkitt's lymphoma and nasopharyngeal carcinoma.

Authors:  S H Zhang
Journal:  Cancer Genet Cytogenet       Date:  1986-11

3.  A mechanism of x chromosome aneuploidy in lymphocytes of aging women.

Authors:  P H Fitzgerald
Journal:  Humangenetik       Date:  1975-06-19

4.  Sequence of centromere separation: analysis of mitotic chromosomes in man.

Authors:  B K Vig
Journal:  Hum Genet       Date:  1981       Impact factor: 4.132

5.  Total aneuploidy and age-related sex chromosome aneuploidy in cultured lymphocytes of normal men and women.

Authors:  P H Fitzgerald; C M McEwan
Journal:  Hum Genet       Date:  1977-12-23       Impact factor: 4.132

6.  Sequence of centromere separation another mechanism for the origin of nondisjunction.

Authors:  B K Vig
Journal:  Hum Genet       Date:  1984       Impact factor: 4.132

7.  Siblings with chromosome mosaicism, microcephaly, and growth retardation: the phenotypic expression of a human mitotic mutant?

Authors:  J L Tolmie; E Boyd; P Batstone; M E Ferguson-Smith; L al Roomi; J M Connor
Journal:  Hum Genet       Date:  1988-10       Impact factor: 4.132

8.  Roberts syndrome and SC phocomelia. A single genetic entity.

Authors:  C Römke; U Froster-Iskenius; K Heyne; W Höhn; M Hof; G Grzejszczyk; R Rauskolb; H Rehder; E Schwinger
Journal:  Clin Genet       Date:  1987-03       Impact factor: 4.438

9.  Evidence for the repeated primary non-disjunction of chromosome 21 as a result of premature centromere division (PCD).

Authors:  P H Fitzgerald; S A Archer; C M Morris
Journal:  Hum Genet       Date:  1986-01       Impact factor: 4.132

10.  Colchicine resistance in human cell lines. Pleiotropic phenotype and decreased membrane permeability.

Authors:  Y Chamla; J Bégueret
Journal:  Hum Genet       Date:  1982       Impact factor: 4.132
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  3 in total

1.  "Premature anaphase" in a couple with recurrent miscarriages.

Authors:  K Bajnóczky; S Gardó
Journal:  Hum Genet       Date:  1993-10       Impact factor: 4.132

2.  Asymmetry and skin pigmentary anomalies in chromosome mosaicism.

Authors:  C G Woods; A Bankier; J Curry; L J Sheffield; S F Slaney; K Smith; L Voullaire; D Wellesley
Journal:  J Med Genet       Date:  1994-09       Impact factor: 6.318

3.  Pathogenic correlation between mosaic variegated aneuploidy 1 (MVA1) and a novel BUB1B variant: a reappraisal of a severe syndrome.

Authors:  Piero Pavone; Xena Giada Pappalardo; Naira Mustafa; Raffaele Falsaperla; Simona Domenica Marino; Giovanni Corsello; Sebastiano Bianca; Enrico Parano; Martino Ruggieri
Journal:  Neurol Sci       Date:  2022-07-09       Impact factor: 3.307
  3 in total

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