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Literature DB >> 23070998

Modular assembly of protein building blocks to create precisely defined megamolecules.

Justin A Modica¹, Stratos Skarpathiotis, Milan Mrksich.

Abstract

Enzyme-promoted assembly: The construction of a hetero-bifunctional protein building block, HaloTag-cutinase, that reacts rapidly and selectively with a small-molecule linker is described. The step-wise combination of these building blocks generates a 300 kDa "megamolecule" with precisely defined domain orientation, connectivity, and composition.

Entities: Chemical

Mesh：

Substances：

Year: 2012 PMID： 23070998 PMCID： PMC3804166 DOI： 10.1002/cbic.201200501

Source DB: PubMed Journal: Chembiochem ISSN： 1439-4227 Impact factor: 3.164

16 in total

1. Nanohedra: using symmetry to design self assembling protein cages, layers, crystals, and filaments.

Authors: J E Padilla; C Colovos; T O Yeates
Journal: Proc Natl Acad Sci U S A Date: 2001-02-20 Impact factor: 11.205

2. Directed evolution of O6-alkylguanine-DNA alkyltransferase for efficient labeling of fusion proteins with small molecules in vivo.

Authors: Alexandre Juillerat; Thomas Gronemeyer; Antje Keppler; Susanne Gendreizig; Horst Pick; Horst Vogel; Kai Johnsson
Journal: Chem Biol Date: 2003-04

3. Folding DNA to create nanoscale shapes and patterns.

Authors: Paul W K Rothemund
Journal: Nature Date: 2006-03-16 Impact factor: 49.962

4. HaloTag: a novel protein labeling technology for cell imaging and protein analysis.

Authors: Georgyi V Los; Lance P Encell; Mark G McDougall; Danette D Hartzell; Natasha Karassina; Chad Zimprich; Monika G Wood; Randy Learish; Rachel Friedman Ohana; Marjeta Urh; Dan Simpson; Jacqui Mendez; Kris Zimmerman; Paul Otto; Gediminas Vidugiris; Ji Zhu; Aldis Darzins; Dieter H Klaubert; Robert F Bulleit; Keith V Wood
Journal: ACS Chem Biol Date: 2008-06-20 Impact factor: 5.100

5. A calcium-modulated plasmonic switch.

Authors: W Paige Hall; Jeffrey N Anker; Yao Lin; Justin Modica; Milan Mrksich; Richard P Van Duyne
Journal: J Am Chem Soc Date: 2008-04-11 Impact factor: 15.419

6. A designed protein for the specific and covalent heteroconjugation of biomolecules.

Authors: Christopher Chidley; Katarzyna Mosiewicz; Kai Johnsson
Journal: Bioconjug Chem Date: 2008-08-28 Impact factor: 4.774

7. Size, shape, and flexibility of proteins and DNA.

Authors: Nidhi Rawat; Parbati Biswas
Journal: J Chem Phys Date: 2009-10-28 Impact factor: 3.488

8. The largest synthetic structure with molecular precision: towards a molecular object.

Authors: Baozhong Zhang; Roger Wepf; Karl Fischer; Manfred Schmidt; Sébastien Besse; Peter Lindner; Benjamin T King; Reinhard Sigel; Peter Schurtenberger; Yeshayahu Talmon; Yi Ding; Martin Kröger; Avraham Halperin; A Dieter Schlüter
Journal: Angew Chem Int Ed Engl Date: 2010-12-22 Impact factor: 15.336

4. Green fluorescent protein nanopolygons as monodisperse supramolecular assemblies of functional proteins with defined valency.

Authors: Young Eun Kim; Yu-na Kim; Jung A Kim; Ho Min Kim; Yongwon Jung
Journal: Nat Commun Date: 2015-05-14 Impact factor: 14.919

4 in total

Modular assembly of protein building blocks to create precisely defined megamolecules.

1. Nanohedra: using symmetry to design self assembling protein cages, layers, crystals, and filaments.

2. Directed evolution of O6-alkylguanine-DNA alkyltransferase for efficient labeling of fusion proteins with small molecules in vivo.

3. Folding DNA to create nanoscale shapes and patterns.

4. HaloTag: a novel protein labeling technology for cell imaging and protein analysis.

5. A calcium-modulated plasmonic switch.

6. A designed protein for the specific and covalent heteroconjugation of biomolecules.

7. Size, shape, and flexibility of proteins and DNA.

8. The largest synthetic structure with molecular precision: towards a molecular object.

9. The frequency of translational misreading errors in E. coli is largely determined by tRNA competition.

10. The structure and conformation of Lys63-linked tetraubiquitin.

1. Solid-Phase Synthesis of Megamolecules.

2. Programmable polyproteams built using twin peptide superglues.

Review 3. HaloTag technology: a versatile platform for biomedical applications.

4. Green fluorescent protein nanopolygons as monodisperse supramolecular assemblies of functional proteins with defined valency.