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Literature DB >> 230691

Myelin lesions in the rabbit eye model as a bystander effect of herpes simplex and visna virus sensitization.

K Kristensson, H Thormar, H M Wisniewski.

Abstract

Rabbits were immunized with herpes simplex and visna virus in complete Freund's adjuvant. Uv-inactivated herpes virus and the purified visna virus protein p25 injected intraocularly into these rabbits elicited a moderate inflammatory cell infiltration in the epiretinal myelinated nerve fiber bundles accompanied by signs of demyelination. It is therefore apparent that also viral antigen can induce myelin lesions as a so-called "bystander effect" of a cell-mediated immune response (bystander demyelination).

Entities: Disease Species

Mesh：

Substances：
Antigens, Viral

Year: 1979 PMID： 230691 DOI： 10.1007/bf00690522

Source DB: PubMed Journal: Acta Neuropathol ISSN： 0001-6322 Impact factor: 17.088

16 in total

1. Diffusion-in-gel methods for immunological analysis.

Authors: O OUCHTERLONY
Journal: Prog Allergy Date: 1958

2. Polyacrylamide gel electrophoresis of visna virus polypeptides isolated by agarose gel chromatography.

Authors: F H Lin
Journal: J Virol Date: 1978-01 Impact factor: 5.103

3. Central nervous system susceptibility to herpes simplex infection.

Authors: J J Townsend; J R Baringer
Journal: J Neuropathol Exp Neurol Date: 1978-05 Impact factor: 3.685

4. Measurement of antibodies to herpesvirus types 1 and 2 in human sera.

Authors: W E Rawls; K Iwamoto; E Adam; J L Melnick
Journal: J Immunol Date: 1970-03 Impact factor: 5.422

Review 5. Immunopathology of demyelination in autoimmune diseases and virus infections.

Authors: H M Wiśniewski
Journal: Br Med Bull Date: 1977-01 Impact factor: 4.291

6. Theiler's virus-induced demyelination: prevention by immunosuppression.

Authors: H L Lipton; M C Dal Canto
Journal: Science Date: 1976-04-02 Impact factor: 47.728

7. Experimental allergic optic neuritis (EAON) in the rabbit. A new model to study primary demyelinating diseases.

Authors: H M Wiśniewski; B R Bloom
Journal: J Neurol Sci Date: 1975-02 Impact factor: 3.181

8. Autoimmune and virus-induced demyelinating diseases. A review.

Authors: P W Lampert
Journal: Am J Pathol Date: 1978-04 Impact factor: 4.307

9. Arrest of myelination and demyelination in rabbit retina induced by herpes simplex virus infection.

Authors: K Kristensson; H M Wiśniewski
Journal: Neuropathol Appl Neurobiol Date: 1978 Jan-Feb Impact factor: 8.090

10. Neural spread of herpes simplex virus types 1 and 2 in mice after corneal or subcutaneous (footpad) inoculation.

Authors: K Kristensson; A Vahlne; L A Persson; E Lycke
Journal: J Neurol Sci Date: 1978-02 Impact factor: 3.181

6 in total

1. Changes of the central nervous system in herpes zoster.

Authors: M Ruppenthal
Journal: Acta Neuropathol Date: 1980 Impact factor: 17.088

2. Immunological and pathological findings in demyelinating encephalitis associated with canine distemper virus infection.

Authors: M Vandevelde; F Kristensen; B Kristensen; A J Steck; U Kihm
Journal: Acta Neuropathol Date: 1982 Impact factor: 17.088