Literature DB >> 176726

Theiler's virus-induced demyelination: prevention by immunosuppression.

H L Lipton, M C Dal Canto.   

Abstract

The effect of immunosuppression with cyclophosphamide and rabbit antiserum to mouse thymocytes on demyelination induced by Theiler's virus in SJL/J mice was ascertained from Epon-embedded sections (1 micrometer) of the central nervous system. Immunosuppression not only eliminated mononuclear cell infiltrates in the spinal cord white matter, but it also prevented the occurrence of demyelination. These results suggest that demyelination in this infection is immune-mediated.

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Year:  1976        PMID： 176726     DOI： 10.1126/science.176726

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  85 in total

1.  Axonal loss results in spinal cord atrophy, electrophysiological abnormalities and neurological deficits following demyelination in a chronic inflammatory model of multiple sclerosis.

Authors:  D B McGavern; P D Murray; C Rivera-Quiñones; J D Schmelzer; P A Low; M Rodriguez
Journal:  Brain       Date:  2000-03       Impact factor: 13.501

2.  The relevance of animal models in multiple sclerosis research.

Authors:  Aleksandar Denic; Aaron J Johnson; Allan J Bieber; Arthur E Warrington; Moses Rodriguez; Istvan Pirko
Journal:  Pathophysiology       Date:  2011-02

3.  Quantitative ultrastructural analysis of a single spinal cord demyelinated lesion predicts total lesion load, axonal loss, and neurological dysfunction in a murine model of multiple sclerosis.

Authors:  S Sathornsumetee; D B McGavern; D R Ure; M Rodriguez
Journal:  Am J Pathol       Date:  2000-10       Impact factor: 4.307

4.  The interaction of two groups of murine genes determines the persistence of Theiler's virus in the central nervous system.

Authors:  J F Bureau; X Montagutelli; S Lefebvre; J L Guénet; M Pla; M Brahic
Journal:  J Virol       Date:  1992-08       Impact factor: 5.103

5.  The relationship between viral RNA, myelin-specific mRNAs, and demyelination in central nervous system disease during Theiler's virus infection.

Authors:  M Yamada; A Zurbriggen; R S Fujinami
Journal:  Am J Pathol       Date:  1990-12       Impact factor: 4.307

6.  Multiple sclerosis. Animal model:Theiler's virus infection in mice.

Authors:  M C Dal Canto; H L Lipton
Journal:  Am J Pathol       Date:  1977-08       Impact factor: 4.307

7.  Transgenic expression of viral capsid proteins predisposes to axonal injury in a murine model of multiple sclerosis.

Authors:  Aleksandar Denic; Laurie Zoecklein; Jason Kerkvliet; Louisa Papke; Ramakrishna Edukulla; Arthur Warrington; Allan Bieber; Larry R Pease; Chella S David; Moses Rodriguez
Journal:  Brain Pathol       Date:  2011-02-11       Impact factor: 6.508

8.  Role of macrophages during Theiler's virus infection.

Authors:  C P Rossi; M Delcroix; I Huitinga; A McAllister; N van Rooijen; E Claassen; M Brahic
Journal:  J Virol       Date:  1997-04       Impact factor: 5.103

9.  Differential virus replication, cytokine production, and antigen-presenting function by microglia from susceptible and resistant mice infected with Theiler's virus.

Authors:  Young-Hee Jin; Mani Mohindru; Min H Kang; Alyson C Fuller; Bongsu Kang; Daniel Gallo; Byung S Kim
Journal:  J Virol       Date:  2007-08-22       Impact factor: 5.103

10.  Gamma interferon is critical for resistance to Theiler's virus-induced demyelination.

Authors:  M Rodriguez; K Pavelko; R L Coffman
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103
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