| Literature DB >> 23063707 |
Marilia A Calcia1, Caroline Madeira, Flavio V Alheira, Thuany C S Silva, Filippe M Tannos, Charles Vargas-Lopes, Nelson Goldenstein, Marco Antonio Brasil, Sergio T Ferreira, Rogerio Panizzutti.
Abstract
Changes in D-serine availability in the brain may contribute to the hypofunction of NMDA-glutamate receptors in schizophrenia; however, measurements of blood levels of D-serine in individuals with schizophrenia have not been consistent amongst previous studies. Here we studied plasma levels of D-serine and L-serine in 84 Brazilian individuals with schizophrenia and 75 gender- and age-matched controls. Plasma levels of D-serine and the ratio of plasma D-serine to total serine were significantly lower in individuals with schizophrenia as compared to the control group. Levels of D-serine were significantly and negatively correlated to the severity of negative symptoms of schizophrenia. We also observed that plasma levels of D-serine significantly decreased with aging in healthy controls. Our results suggest that the possible role of D-serine in the pathophysiology of schizophrenia should be further investigated, with possible implications for the drug treatment of this disorder.Entities:
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Year: 2012 PMID： 23063707 DOI： 10.1016/j.schres.2012.09.014
Source DB: PubMed Journal: Schizophr Res ISSN： 0920-9964 Impact factor: 4.939