OBJECTIVES: We evaluated the effect of autogenous bone (AB) and hydroxyapatite bone (HA) for the assessment of bone augmentation beyond the skeletal envelope in the rat calvarium. STUDY DESIGN: The calvaria of 12 rats were exposed and 2 plastic caps were placed with AB and HA or AB alone in the calvarium. Images of bone augmentation within the plastic caps were taken using micro-CT (R_mCT). Histologic sections were cut along the same plane as those used for the R_mCT images at 12 weeks. Bone volume (BV) was calculated using BV-measuring software. RESULTS: BV increased at both the experimental and control sites. The newly generated tissue did not significantly differ between the experimental and control sites; however, the mineralized tissue was significantly higher at control sites compared with experimental sites. CONCLUSIONS: The results indicate that the combination of HA and AB was biocompatible and allowed osteoconduction.
OBJECTIVES: We evaluated the effect of autogenous bone (AB) and hydroxyapatite bone (HA) for the assessment of bone augmentation beyond the skeletal envelope in the rat calvarium. STUDY DESIGN: The calvaria of 12 rats were exposed and 2 plastic caps were placed with AB and HA or AB alone in the calvarium. Images of bone augmentation within the plastic caps were taken using micro-CT (R_mCT). Histologic sections were cut along the same plane as those used for the R_mCT images at 12 weeks. Bone volume (BV) was calculated using BV-measuring software. RESULTS: BV increased at both the experimental and control sites. The newly generated tissue did not significantly differ between the experimental and control sites; however, the mineralized tissue was significantly higher at control sites compared with experimental sites. CONCLUSIONS: The results indicate that the combination of HA and AB was biocompatible and allowed osteoconduction.
Authors: Lucas A Kinard; Rebecca L Dahlin; Johnny Lam; Steven Lu; Esther J Lee; F Kurtis Kasper; Antonios G Mikos Journal: Acta Biomater Date: 2014-07-18 Impact factor: 8.947
Authors: Soraya da Silva Oliveira; Pedro Henrique Mattos de Carvalho; Cássio Edvard Sverzut; Alexandre Elias Trivellato Journal: Oral Maxillofac Surg Date: 2022-01-12