PURPOSE: Oxidative stress has been implicated in Down syndrome (DS) pathology. This study compares DS individuals and controls on their urinary levels of allantoin and 2,3-dinor-iPF2α-III; these biomarkers have been previously validated in a clinical model of oxidative stress. METHODS: Urine samples were collected from 48 individuals with DS and 130 controls. Biomarkers were assayed by ultraperformance liquid chromatography-tandem mass spectrometry, normalized by urinary creatinine concentration. RESULTS: After adjusting for age and gender, mean allantoin levels were lower among DS individuals versus controls (P = .04). The adjusted mean levels of 2,3-dinor-iPF2α-III were similar in DS individuals and controls (P = .7). CONCLUSIONS: Our results do not support the hypothesis that DS individuals have chronic systemic oxidative stress.
PURPOSE: Oxidative stress has been implicated in Down syndrome (DS) pathology. This study compares DS individuals and controls on their urinary levels of allantoin and 2,3-dinor-iPF2α-III; these biomarkers have been previously validated in a clinical model of oxidative stress. METHODS: Urine samples were collected from 48 individuals with DS and 130 controls. Biomarkers were assayed by ultraperformance liquid chromatography-tandem mass spectrometry, normalized by urinary creatinine concentration. RESULTS: After adjusting for age and gender, mean allantoin levels were lower among DS individuals versus controls (P = .04). The adjusted mean levels of 2,3-dinor-iPF2α-III were similar in DS individuals and controls (P = .7). CONCLUSIONS: Our results do not support the hypothesis that DS individuals have chronic systemic oxidative stress.
Authors: Dora Il'yasova; Frances Wang; Ivan Spasojevic; Karel Base; Ralph B D'Agostino; Lynne E Wagenknecht Journal: Obesity (Silver Spring) Date: 2011-09-29 Impact factor: 5.002
Authors: Dora Il'yasova; Ivan Spasojevic; Frances Wang; Adviye A Tolun; Karel Base; Sarah P Young; P Kelly Marcom; Jeffrey Marks; Gabriel Mixon; Richard DiGiulio; David S Millington Journal: Cancer Epidemiol Biomarkers Prev Date: 2010-05-25 Impact factor: 4.254
Authors: Adviye A Tolun; Haoyue Zhang; Dora Il'yasova; Judit Sztáray; Sarah P Young; David S Millington Journal: Anal Biochem Date: 2010-03-31 Impact factor: 3.365
Authors: Haoyue Zhang; Dora Il'yasova; Judit Sztaray; Sarah P Young; Frances Wang; David S Millington Journal: Anal Biochem Date: 2009-12-22 Impact factor: 3.365
Authors: Sarah P Young; Haoyue Zhang; Deyanira Corzo; Beth L Thurberg; Deeksha Bali; Priya S Kishnani; David S Millington Journal: Genet Med Date: 2009-07 Impact factor: 8.822
Authors: Eugenio Barone; Andrea Arena; Elizabeth Head; D Allan Butterfield; Marzia Perluigi Journal: Free Radic Biol Med Date: 2017-07-10 Impact factor: 7.376
Authors: D Allan Butterfield; Fabio Di Domenico; Aaron M Swomley; Elizabeth Head; Marzia Perluigi Journal: Biochem J Date: 2014-10-15 Impact factor: 3.857
Authors: Panagiotis Zis; Patrick McHugh; Andrew McQuillin; Domenico Praticò; Mark Dickinson; Sima Shende; Zuzana Walker; Andre Strydom Journal: PLoS One Date: 2014-06-05 Impact factor: 3.240
Authors: Francis Annor; Michael Goodman; Bharat Thyagarajan; Ike Okosun; Ayo Doumatey; Barbara A Gower; Dora Il'yasova Journal: Oxid Med Cell Longev Date: 2017-01-31 Impact factor: 6.543