Literature DB >> 20361921

Allantoin in human urine quantified by ultra-performance liquid chromatography-tandem mass spectrometry.

Adviye A Tolun1, Haoyue Zhang, Dora Il'yasova, Judit Sztáray, Sarah P Young, David S Millington.   

Abstract

Uric acid is a potent antioxidant and scavenger of singlet oxygen and other radicals in humans. Allantoin, the predominant product of free radical-induced oxidation of uric acid, is efficiently excreted in the urine and has potential as a biomarker of oxidative stress. We developed a rapid and specific assay for urinary allantoin using ultra-performance liquid chromatography-tandem mass spectrometry suitable for high-throughput clinical studies. The method required minimal sample preparation and was accurate (mean error=6%), precise (intra- and interday imprecision <8%), and sensitive (limit of detection=0.06pmol). Allantoin levels measured in control samples were comparable to literature values. 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20361921      PMCID： PMC3595192          DOI： 10.1016/j.ab.2010.03.033

Source DB:  PubMed          Journal:  Anal Biochem        ISSN： 0003-2697            Impact factor:   3.365


  22 in total

1.  Quantitative determination of an extremely polar compound allantoin in human urine by LC-MS/MS based on the separation on a polymeric amino column.

Authors:  A Berthemy; J Newton; D Wu; D Buhrman
Journal:  J Pharm Biomed Anal       Date:  1999-03       Impact factor: 3.935

Review 2.  Measuring reactive species and oxidative damage in vivo and in cell culture: how should you do it and what do the results mean?

Authors:  Barry Halliwell; Matthew Whiteman
Journal:  Br J Pharmacol       Date:  2004-05       Impact factor: 8.739

3.  Improved HPLC method for the simultaneous measurement of allantoin and uric acid in plasma.

Authors:  O Lux; D Naidoo; C Salonikas
Journal:  Ann Clin Biochem       Date:  1992-11       Impact factor: 2.057

4.  Assay of serum allantoin in humans by gas chromatography-mass spectrometry.

Authors:  Darrell V Pavitt; Sue de Fonseka; Nisrin Al-Khalaf; Janice M Cam; David A Reaveley
Journal:  Clin Chim Acta       Date:  2002-04       Impact factor: 3.786

5.  Measurement of allantoin and uric acid in human body fluids. A potential index of free-radical reactions in vivo?

Authors:  M Grootveld; B Halliwell
Journal:  Biochem J       Date:  1987-05-01       Impact factor: 3.857

6.  Action of biologically-relevant oxidizing species upon uric acid. Identification of uric acid oxidation products.

Authors:  H Kaur; B Halliwell
Journal:  Chem Biol Interact       Date:  1990       Impact factor: 5.192

7.  Effects of xanthine oxidase inhibition with allopurinol on endothelial function and peripheral blood flow in hyperuricemic patients with chronic heart failure: results from 2 placebo-controlled studies.

Authors:  Wolfram Doehner; Nina Schoene; Mathias Rauchhaus; Francisco Leyva-Leon; Darrell V Pavitt; David A Reaveley; Gerhard Schuler; Andrew J S Coats; Stefan D Anker; Rainer Hambrecht
Journal:  Circulation       Date:  2002-06-04       Impact factor: 29.690

8.  Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry.

Authors:  Kyung Mee Kim; George N Henderson; Reginald F Frye; Cheryl D Galloway; Nancy J Brown; Mark S Segal; Witcha Imaram; Alexander Angerhofer; Richard J Johnson
Journal:  J Chromatogr B Analyt Technol Biomed Life Sci       Date:  2008-11-25       Impact factor: 3.205

9.  Oxidation of uric acid in rheumatoid arthritis: is allantoin a marker of oxidative stress?

Authors:  Sevgi Yardim-Akaydin; Aylin Sepici; Yeşim Ozkan; Meral Torun; Bolkan Simşek; Vesile Sepici
Journal:  Free Radic Res       Date:  2004-06

10.  Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

Authors:  B N Ames; R Cathcart; E Schwiers; P Hochstein
Journal:  Proc Natl Acad Sci U S A       Date:  1981-11       Impact factor: 11.205
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  15 in total

Review 1.  Urinary biomarkers of oxidative status.

Authors:  Dora Il'yasova; Peter Scarbrough; Ivan Spasojevic
Journal:  Clin Chim Acta       Date:  2012-06-07       Impact factor: 3.786

2.  Urinary Allantoin Is Elevated in Severe Intraventricular Hemorrhage in the Preterm Newborn.

Authors:  Ijeoma Esiaba; Danilyn M Angeles; Megan S Holden; John B C Tan; Yayesh Asmerom; Gerald Gollin; Danilo S Boskovic
Journal:  Transl Stroke Res       Date:  2015-05-22       Impact factor: 6.829

3.  Individual responses to chemotherapy-induced oxidative stress.

Authors:  Dora Il'yasova; Kelly Kennedy; Ivan Spasojevic; Frances Wang; Adviye A Tolun; Karel Base; Sarah P Young; P Kelly Marcom; Jeffrey Marks; David S Millington; Mark W Dewhirst
Journal:  Breast Cancer Res Treat       Date:  2010-09-10       Impact factor: 4.872

4.  Urine gastrin-releasing peptide in the first week correlates with bronchopulmonary dysplasia and post-prematurity respiratory disease.

Authors:  Judith A Voynow; Kimberley Fisher; Mary E Sunday; Charles M Cotten; Aaron Hamvas; Karen D Hendricks-Muñoz; Brenda B Poindexter; Gloria S Pryhuber; Clement L Ren; Rita M Ryan; Jack K Sharp; Sarah P Young; Haoyue Zhang; Rachel G Greenberg; Amy H Herring; Stephanie D Davis
Journal:  Pediatr Pulmonol       Date:  2020-01-29

5.  Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice.

Authors:  Benjamin M Fox; Hyo-Wook Gil; Lara Kirkbride-Romeo; Rushita A Bagchi; Sara A Wennersten; Korey R Haefner; Nataliya I Skrypnyk; Carolyn N Brown; Danielle E Soranno; Katja M Gist; Benjamin R Griffin; Anna Jovanovich; Julie A Reisz; Matthew J Wither; Angelo D'Alessandro; Charles L Edelstein; Nathan Clendenen; Timothy A McKinsey; Christopher Altmann; Sarah Faubel
Journal:  Kidney Int       Date:  2019-01-30       Impact factor: 10.612

6.  Systemic oxidative stress, as measured by urinary allantoin and F(2)-isoprostanes, is not increased in Down syndrome.

Authors:  Adviye A Tolun; Peter M Scarbrough; Haoyue Zhang; Jane-Ann McKillop; Frances Wang; Priya S Kishnani; David S Millington; Sarah P Young; Dora Il'yasova
Journal:  Ann Epidemiol       Date:  2012-10-11       Impact factor: 3.797

7.  Potential mechanisms for low uric acid in Parkinson disease.

Authors:  Radhika Sampat; Sarah Young; Ami Rosen; Douglas Bernhard; David Millington; Stewart Factor; H A Jinnah
Journal:  J Neural Transm (Vienna)       Date:  2016-01-08       Impact factor: 3.575

8.  Oxidative Stress Biomarker Decreased in Preterm Neonates Treated With Kangaroo Mother Care.

Authors:  Dorothy Forde; Douglas D Deming; John C Tan; Raylene M Phillips; Eileen K Fry-Bowers; Mary K Barger; Khaled Bahjri; Danilyn M Angeles; Danilo S Boskovic
Journal:  Biol Res Nurs       Date:  2020-01-24       Impact factor: 2.522

9.  Urinary F2-isoprostanes as a biomarker of reduced risk of type 2 diabetes.

Authors:  Dora Il'yasova; Ivan Spasojevic; Karel Base; Haoyue Zhang; Frances Wang; Sarah P Young; David S Millington; Ralph B D'Agostino; Lynne E Wagenknecht
Journal:  Diabetes Care       Date:  2011-11-18       Impact factor: 19.112

10.  Identification of key uric acid synthesis pathway in a unique mutant silkworm Bombyx mori model of Parkinson's disease.

Authors:  Hiroko Tabunoki; Hiromasa Ono; Hiroaki Ode; Kazuhiro Ishikawa; Natsuki Kawana; Yutaka Banno; Toru Shimada; Yuki Nakamura; Kimiko Yamamoto; Jun-Ichi Satoh; Hidemasa Bono
Journal:  PLoS One       Date:  2013-07-24       Impact factor: 3.240
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