OBJECTIVE: The inability to ignore irrelevant environmental noise is a common problem for people with schizophrenia. The purpose of this study was to determine if the neuronal response to distracting noise is related to mechanisms of altered attention observed in the illness. METHOD: Twenty-two outpatients with schizophrenia and seventeen healthy comparison subjects performed a selective attention task in the presence or absence of distracting environmental noise while undergoing functional magnetic resonance imaging at 3T. A separate condition examining passive response to the distracting noise also was included. RESULTS: Group differences in neuronal response during the attention task were magnified by distracting noise, with the greatest difference being less response by patients, relative to comparison subjects, in the temporoparietal junction. Separate passive listening to distracting noise resulted in greater hippocampal response in patients, relative to comparison subjects. Across all subjects, hippocampal response to noise was inversely related to the degree to which the attention-task-related network was up-regulated to perform the task during distracting noise. CONCLUSIONS: Given the observed hippocampal hyperactivity in response to environmental noise in patients and the inverse relationship between hippocampal response to noise and the effects of noise on the task-related network, hippocampal hyperactivity may contribute to impaired recruitment of attention networks in schizophrenia. Published by Elsevier B.V.
OBJECTIVE: The inability to ignore irrelevant environmental noise is a common problem for people with schizophrenia. The purpose of this study was to determine if the neuronal response to distracting noise is related to mechanisms of altered attention observed in the illness. METHOD: Twenty-two outpatients with schizophrenia and seventeen healthy comparison subjects performed a selective attention task in the presence or absence of distracting environmental noise while undergoing functional magnetic resonance imaging at 3T. A separate condition examining passive response to the distracting noise also was included. RESULTS: Group differences in neuronal response during the attention task were magnified by distracting noise, with the greatest difference being less response by patients, relative to comparison subjects, in the temporoparietal junction. Separate passive listening to distracting noise resulted in greater hippocampal response in patients, relative to comparison subjects. Across all subjects, hippocampal response to noise was inversely related to the degree to which the attention-task-related network was up-regulated to perform the task during distracting noise. CONCLUSIONS: Given the observed hippocampal hyperactivity in response to environmental noise in patients and the inverse relationship between hippocampal response to noise and the effects of noise on the task-related network, hippocampal hyperactivity may contribute to impaired recruitment of attention networks in schizophrenia. Published by Elsevier B.V.
Authors: Kent A Kiehl; Michael C Stevens; Kristin R Laurens; Godfrey Pearlson; Vince D Calhoun; Peter F Liddle Journal: Neuroimage Date: 2005-04-15 Impact factor: 6.556
Authors: Robert J Thoma; Faith M Hanlon; Sandra N Moses; Daniel Ricker; Mingxiong Huang; Christopher Edgar; Jessica Irwin; Fernando Torres; Michael P Weisend; Lawrence E Adler; Gregory A Miller; Jose M Canive Journal: Schizophr Res Date: 2005-03-01 Impact factor: 4.939
Authors: Veena Kumari; Elena Antonova; Mark A Geyer; Dominic Ffytche; Steven C R Williams; Tonmoy Sharma Journal: Int J Neuropsychopharmacol Date: 2006-08-21 Impact factor: 5.176
Authors: Jason R Tregellas; Deana B Davalos; Donald C Rojas; Merilyne C Waldo; Linzi Gibson; Korey Wylie; Yiping P Du; Robert Freedman Journal: Schizophr Res Date: 2007-03-02 Impact factor: 4.939
Authors: Jason R Tregellas; Jason Smucny; Josette G Harris; Ann Olincy; Keeran Maharajh; Eugene Kronberg; Lindsay C Eichman; Emma Lyons; Robert Freedman Journal: Am J Psychiatry Date: 2014-05 Impact factor: 18.112
Authors: Daniel Shepherd; Marja Heinonen-Guzejev; Kauko Heikkilä; Kim N Dirks; Michael J Hautus; David Welch; David McBride Journal: Int J Environ Res Public Health Date: 2015-05-18 Impact factor: 3.390
Authors: Andrew R Mayer; Faith M Hanlon; Terri M Teshiba; Stefan D Klimaj; Josef M Ling; Andrew B Dodd; Vince D Calhoun; Juan R Bustillo; Trent Toulouse Journal: Br J Psychiatry Date: 2015-09-17 Impact factor: 9.319
Authors: Arthur A Berberian; Giovanna V Moraes; Ary Gadelha; Elisa Brietzke; Ana O Fonseca; Bruno S Scarpato; Marcella O Vicente; Alessandra G Seabra; Rodrigo A Bressan; Acioly L Lacerda Journal: Braz J Psychiatry Date: 2016-04-19 Impact factor: 2.697