OBJECTIVES: The objective of this study was to examine the similarities and differences in Caucasian (C) and African-American (AA) patients with bicuspid aortic valve (BAV) with respect to morphology, severity of aortic stenosis/insufficiency, and aortic dilation. BACKGROUND: BAV is a common congenital valve abnormality, accounting for a large number of valve replacements. METHODS: A total of 229 patients with the diagnostic code BAV were identified retrospectively from our computerized adult echocardiographic database, which consists of 91,896 studies performed at the University of Chicago Medical Center from 1998 to 2009, representing 40,878 patients. Of those, 183 patients with BAV were included in this retrospective BAV single-center cohort study and reanalyzed with a comprehensive assessment of aortic dimensions, aortic valve morphology and function, clinical cardiovascular risk factors, and patient characteristics. RESULTS: Of the 183 patients with BAV, 138 were C and 45 were AA. Our echocardiographic database encompasses approximately 65% AA, 31% C, and 4% other races, for an estimated frequency of BAV in AA patients of 0.17% and a frequency in C patients of 1.1% (p = 0.001). There were no significant inter-racial differences regarding sex, height, weight, hyperlipidemia, diabetes, tobacco use, cardiac medications, and left ventricular ejection fraction. The AA cohort was older (age 50 ± 17 years vs. 43 ± 17 years, p < 0.05) and had a higher prevalence of hypertension (51% vs. 24%, p < 0.05). After adjusting for comorbidities, aortic dimensions were larger in C (C vs. AA: annulus, 2.4 ± 0.4 vs. 2.1 ± 0.4 cm; sinuses of Valsalva, 3.4 ± 0.7 vs. 3.1 ± 0.6 cm; sinotubular junction, 3.0 ± 0.6 vs. 2.6 ± 0.5 cm; and ascending aorta, 3.5 ± 0.7 vs. 3.2 ± 0.5 cm; all p values <0.05). CONCLUSIONS: This is the first study to report racial differences among patients with BAV with reduced aortic dimensions in AA patients despite the presence of more risk factors, suggestive of marked heterogeneity in the BAV population and indicating race as a potential disease modifier in BAV.
OBJECTIVES: The objective of this study was to examine the similarities and differences in Caucasian (C) and African-American (AA) patients with bicuspid aortic valve (BAV) with respect to morphology, severity of aortic stenosis/insufficiency, and aortic dilation. BACKGROUND: BAV is a common congenital valve abnormality, accounting for a large number of valve replacements. METHODS: A total of 229 patients with the diagnostic code BAV were identified retrospectively from our computerized adult echocardiographic database, which consists of 91,896 studies performed at the University of Chicago Medical Center from 1998 to 2009, representing 40,878 patients. Of those, 183 patients with BAV were included in this retrospective BAV single-center cohort study and reanalyzed with a comprehensive assessment of aortic dimensions, aortic valve morphology and function, clinical cardiovascular risk factors, and patient characteristics. RESULTS: Of the 183 patients with BAV, 138 were C and 45 were AA. Our echocardiographic database encompasses approximately 65% AA, 31% C, and 4% other races, for an estimated frequency of BAV in AA patients of 0.17% and a frequency in C patients of 1.1% (p = 0.001). There were no significant inter-racial differences regarding sex, height, weight, hyperlipidemia, diabetes, tobacco use, cardiac medications, and left ventricular ejection fraction. The AA cohort was older (age 50 ± 17 years vs. 43 ± 17 years, p < 0.05) and had a higher prevalence of hypertension (51% vs. 24%, p < 0.05). After adjusting for comorbidities, aortic dimensions were larger in C (C vs. AA: annulus, 2.4 ± 0.4 vs. 2.1 ± 0.4 cm; sinuses of Valsalva, 3.4 ± 0.7 vs. 3.1 ± 0.6 cm; sinotubular junction, 3.0 ± 0.6 vs. 2.6 ± 0.5 cm; and ascending aorta, 3.5 ± 0.7 vs. 3.2 ± 0.5 cm; all p values <0.05). CONCLUSIONS: This is the first study to report racial differences among patients with BAV with reduced aortic dimensions in AA patients despite the presence of more risk factors, suggestive of marked heterogeneity in the BAV population and indicating race as a potential disease modifier in BAV.
Authors: Linda Cripe; Gregor Andelfinger; Lisa J Martin; Kerry Shooner; D Woodrow Benson Journal: J Am Coll Cardiol Date: 2004-07-07 Impact factor: 24.094
Authors: Loren F Hiratzka; George L Bakris; Joshua A Beckman; Robert M Bersin; Vincent F Carr; Donald E Casey; Kim A Eagle; Luke K Hermann; Eric M Isselbacher; Ella A Kazerooni; Nicholas T Kouchoukos; Bruce W Lytle; Dianna M Milewicz; David L Reich; Souvik Sen; Julie A Shinn; Lars G Svensson; David M Williams Journal: Catheter Cardiovasc Interv Date: 2010-08-01 Impact factor: 2.692
Authors: Barbara L Kroner; H Eser Tolunay; Craig T Basson; Reed E Pyeritz; Kathryn W Holmes; Cheryl L Maslen; Dianna M Milewicz; Scott A LeMaire; Tabitha Hendershot; Patrice Desvigne-Nickens; Richard B Devereux; Harry C Dietz; Howard K Song; Danny Ringer; Megan Mitchell; Jonathan W Weinsaft; William Ravekes; Victor Menashe; Kim A Eagle Journal: Am Heart J Date: 2011-10 Impact factor: 4.749
Authors: Xiaoqin Liu; Hisato Yagi; Shazina Saeed; Abha S Bais; George C Gabriel; Zhaohan Chen; Kevin A Peterson; You Li; Molly C Schwartz; William T Reynolds; Manush Saydmohammed; Brian Gibbs; Yijen Wu; William Devine; Bishwanath Chatterjee; Nikolai T Klena; Dennis Kostka; Karen L de Mesy Bentley; Madhavi K Ganapathiraju; Phillip Dexheimer; Linda Leatherbury; Omar Khalifa; Anchit Bhagat; Maliha Zahid; William Pu; Simon Watkins; Paul Grossfeld; Stephen A Murray; George A Porter; Michael Tsang; Lisa J Martin; D Woodrow Benson; Bruce J Aronow; Cecilia W Lo Journal: Nat Genet Date: 2017-05-22 Impact factor: 38.330
Authors: Alexander P Taylor; Ajay Yadlapati; Adin-Cristian Andrei; Zhi Li; Colleen Clennon; Patrick M McCarthy; James D Thomas; S Chris Malaisrie; Neil J Stone; Robert O Bonow; Paul W M Fedak; Jyothy J Puthumana Journal: Clin Cardiol Date: 2015-12-22 Impact factor: 2.882
Authors: Hisato Yagi; Xiaoqin Liu; George C Gabriel; Yijen Wu; Kevin Peterson; Stephen A Murray; Bruce J Aronow; Lisa J Martin; D Woodrow Benson; Cecilia W Lo Journal: Pediatr Cardiol Date: 2018-03-22 Impact factor: 1.655
Authors: Hector I Michelena; Alessandro Della Corte; Arturo Evangelista; Joseph J Maleszewski; William D Edwards; Mary J Roman; Richard B Devereux; Borja Fernández; Federico M Asch; Alex J Barker; Lilia M Sierra-Galan; Laurent De Kerchove; Susan M Fernandes; Paul W M Fedak; Evaldas Girdauskas; Victoria Delgado; Suhny Abbara; Emmanuel Lansac; Siddharth K Prakash; Malenka M Bissell; Bogdan A Popescu; Michael D Hope; Marta Sitges; Vinod H Thourani; Phillippe Pibarot; Krishnaswamy Chandrasekaran; Patrizio Lancellotti; Michael A Borger; John K Forrest; John Webb; Dianna M Milewicz; Raj Makkaar; Martin B Leon; Stephen P Sanders; Michael Markl; Victor A Ferrari; William C Roberts; Jae-Kwan Song; Philipp Blanke; Charles S White; Samuel Siu; Lars G Svensson; Alan C Braverman; Joseph Bavaria; Thoralf M Sundt; Gebrine El Khoury; Ruggero De Paulis; Maurice Enriquez-Sarano; Jeroen J Bax; Catherine M Otto; Hans-Joachim Schäfers Journal: Radiol Cardiothorac Imaging Date: 2021-07-22
Authors: Devin K Patel; Kelly D Green; Marat Fudim; Frank E Harrell; Thomas J Wang; Mark A Robbins Journal: J Am Heart Assoc Date: 2014-05-28 Impact factor: 5.501