| Literature DB >> 23057764 |
Kursat Ali Kaplan1, Fehmi Odabasoglu, Zekai Halici, Mesut Halici, Elif Cadirci, Fadime Atalay, Ozlem Aydin, Ahmet Cakir.
Abstract
Gastroprotective effects of α-lipoic acid (ALA) against oxidative gastric damage induced by indomethacin (IND) have been investigated. All doses (50, 75, 100, 150, 200, and 300 mg/kg body weight) of ALA reduced the ulcer index with 88.2% to 96.1% inhibition ratio. In biochemical analyses of stomach tissues, ALA administration decreased the level of lipid peroxidation (LPO) and activities of myeloperoxidase (MPO) and catalase (CAT) in gastric tissues, which were increased after IND application. ALA also increased the level of glutathione (GSH) and activities of superoxide dismutase (SOD) and glutathione S-transferase (GST) that were decreased in gastric damaged stomach tissues. In conclusion, the gastroprotective effect of ALA could be attributed to its ameliorating effect on the antioxidant defense systems.Entities:
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Year: 2012 PMID： 23057764 DOI： 10.1111/j.1750-3841.2012.02920.x
Source DB: PubMed Journal: J Food Sci ISSN： 0022-1147 Impact factor: 3.167