Thomas Kemmerly1, Jonathan D Kaunitz. 1. aCedars-Sinai Medical Residency Program bGreater Los Angeles Veteran Affairs Healthcare System, WLAVA Medical Center cDepartment of Medicine dDepartment of Surgery, UCLA School of Medicine eCURE: Digestive Diseases Research Center Department of Medicine fBrentwood Biomedical Research Institute, Los Angeles, California, USA.
Abstract
PURPOSE OF REVIEW: To review recent developments in the field of gastroduodenal mucosal defense. RECENT FINDINGS: Research in the field of gastroduodenal mucosal defense has focused on continued elucidation of molecular mechanisms that protect the mucosa and influence healing at the cellular level. Review of literature over the past year reveals focus on familiar processes such as superoxide dismutase, nitric oxide, heme oxygenase-1, neutrophil infiltration, cysteamine, mucin, hydrogen sulfide, ghrelin, adiponectin and the influence of Helicobacter pylori, but also brings into light new processes such as the balance between apoptosis and cellular proliferation, as well as the influence of other organ systems such as the bone marrow and central nervous system on the gastrointestinal tract. SUMMARY: These new published findings contribute to our overall understanding of gastroduodenal defense and suggest innovative avenues of future research and possible novel therapeutic targets.
PURPOSE OF REVIEW: To review recent developments in the field of gastroduodenal mucosal defense. RECENT FINDINGS: Research in the field of gastroduodenal mucosal defense has focused on continued elucidation of molecular mechanisms that protect the mucosa and influence healing at the cellular level. Review of literature over the past year reveals focus on familiar processes such as superoxide dismutase, nitric oxide, heme oxygenase-1, neutrophil infiltration, cysteamine, mucin, hydrogen sulfide, ghrelin, adiponectin and the influence of Helicobacter pylori, but also brings into light new processes such as the balance between apoptosis and cellular proliferation, as well as the influence of other organ systems such as the bone marrow and central nervous system on the gastrointestinal tract. SUMMARY: These new published findings contribute to our overall understanding of gastroduodenal defense and suggest innovative avenues of future research and possible novel therapeutic targets.
Authors: Tetyana Khomenko; Joanna Kolodney; John T Pinto; Gordon D McLaren; Xiaoming Deng; Longchuan Chen; Ganna Tolstanova; Brankica Paunovic; Boris F Krasnikov; Neil Hoa; Arthur J L Cooper; Sandor Szabo Journal: Arch Biochem Biophys Date: 2012-06-07 Impact factor: 4.013
Authors: F Sekiguchi; Y Matsumoto; Y Maeda; M Tsubota-Matsunami; H Nishikawa; A Kawabata Journal: J Physiol Pharmacol Date: 2012-12 Impact factor: 3.011
Authors: Amrita Ahluwalia; Mark Gladwin; Gary D Coleman; Norman Hord; George Howard; Daniel B Kim-Shapiro; Martin Lajous; Filip J Larsen; David J Lefer; Leslie A McClure; Bernard T Nolan; Ryszard Pluta; Alan Schechter; Chia-Yih Wang; Mary H Ward; Jane L Harman Journal: J Am Heart Assoc Date: 2016-07-06 Impact factor: 5.501