| Literature DB >> 2305425 |
Abstract
Although current immunoassay kits for digoxin supposedly have antibodies of high specificity, serum digoxin levels in patients taking spironolactone suggest that spironolactone interferes with the determination. In vitro determinations of digoxin performed on blank serum spiked with spironolactone and its metabolite canrenone showed that contrary to the belief gained from reading the manuals of some diagnostic immunoassay kits, spironolactone significantly influences digoxin determinations.Entities:
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Year: 1990 PMID： 2305425 DOI： 10.1097/00007691-199001000-00015
Source DB: PubMed Journal: Ther Drug Monit ISSN： 0163-4356 Impact factor: 3.681