OBJECTIVE AND DESIGN: The purpose of this study was to evaluate the anti-inflammatory and anti-arthritic activities of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (β-lapachone; β-lap) and to elucidate its probable mode of action. METHODS: Carrageenan-induced paw edema, cell migration evaluation and production of pro-inflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-6 and nitric oxide were used for this study. Freund's complete adjuvant (FCA)-induced arthritis was used as a model of chronic inflammation. β-Lap was tested in doses of 40 and 60 mg/kg, orally. RESULTS: In the paw edema test, the dose of 60 mg/kg gave a higher percentage inhibition of edema (49.3 %) than control. β-Lap inhibited neutrophil migration and reduced concentrations of TNF-α, IL-6 and NO in peritoneal exudates of animals with peritonitis. In the arthritis test, β-lap inhibited edema and NO production in the serum of treated animals. CONCLUSION: Significant anti-inflammatory and anti-arthritic activities were observed in animals treated with β-lap. The effects of β-lap can be attributed in part to immunomodulation with reduction of pro-inflammatory cytokines and NO.
OBJECTIVE AND DESIGN: The purpose of this study was to evaluate the anti-inflammatory and anti-arthritic activities of 3,4-dihydro-2,2-dimethyl-2H-naphthol[1,2-b]pyran-5,6-dione (β-lapachone; β-lap) and to elucidate its probable mode of action. METHODS: Carrageenan-induced paw edema, cell migration evaluation and production of pro-inflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-6 and nitric oxide were used for this study. Freund's complete adjuvant (FCA)-induced arthritis was used as a model of chronic inflammation. β-Lap was tested in doses of 40 and 60 mg/kg, orally. RESULTS: In the paw edema test, the dose of 60 mg/kg gave a higher percentage inhibition of edema (49.3 %) than control. β-Lap inhibited neutrophil migration and reduced concentrations of TNF-α, IL-6 and NO in peritoneal exudates of animals with peritonitis. In the arthritis test, β-lap inhibited edema and NO production in the serum of treated animals. CONCLUSION: Significant anti-inflammatory and anti-arthritic activities were observed in animals treated with β-lap. The effects of β-lap can be attributed in part to immunomodulation with reduction of pro-inflammatory cytokines and NO.
Authors: Sabrina Baptista Ferreira; Kelly Salomão; Fernando de Carvalho da Silva; Antônio Ventura Pinto; Carlos Roland Kaiser; Angelo C Pinto; Vitor Francisco Ferreira; Solange L de Castro Journal: Eur J Med Chem Date: 2011-03-15 Impact factor: 7.088
Authors: Ana L de B Oliveira; Kely C Navegantes-Lima; Valter V S Monteiro; Lucas B G Quadros; Juliana P de Oliveira; Sávio M Dos Santos; Anna C A de A Pontes; Gilson P Dorneles; Pedro R T Romão; Luiz C R Júnior; Alaíde B de Oliveira; Marta C Monteiro Journal: Oxid Med Cell Longev Date: 2020-12-12 Impact factor: 7.310
Authors: Matthew J Foulkes; Faith H Tolliday; Katherine M Henry; Stephen A Renshaw; Simon Jones Journal: PLoS One Date: 2020-10-06 Impact factor: 3.240