| Literature DB >> 21450374 |
Sabrina Baptista Ferreira1, Kelly Salomão, Fernando de Carvalho da Silva, Antônio Ventura Pinto, Carlos Roland Kaiser, Angelo C Pinto, Vitor Francisco Ferreira, Solange L de Castro.
Abstract
The available chemotherapy for Chagas disease, caused by Trypanosoma cruzi, is unsatisfactory; therefore, there is an intense effort to find new drugs for the treatment of this disease. In our laboratory, we have analyzed the effect on bloodstream trypomastigotes of 16 new naphthoquinone analogues of β-lapachone modified in the pyran ring, aiming to find a new prototype with high trypanocidal activity. The new compounds presented a broad spectrum of activity, and five of them presented IC(50)/24 h in the range of 22-63 μM, whereas β-lapachone had a higher value of 391.5 ± 16.5 μM.Entities:
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Year: 2011 PMID： 21450374 DOI： 10.1016/j.ejmech.2011.03.012
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 7.088