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Literature DB >> 23047690

O-GlcNAc cycling modulates neurodegeneration.

Cheng-Xin Gong¹, Fei Liu, Khalid Iqbal.

Abstract

Entities: Disease Gene

Mesh：

Substances：
Acetylglucosamine

Year: 2012 PMID： 23047690 PMCID： PMC3491495 DOI： 10.1073/pnas.1215395109

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

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21 in total

1. Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting.

Authors: Xu Li; Fen Lu; Jian-Zhi Wang; Cheng-Xin Gong
Journal: Eur J Neurosci Date: 2006-04 Impact factor: 3.386

2. Accumulation of protein O-GlcNAc modification inhibits proteasomes in the brain and coincides with neuronal apoptosis in brain areas with high O-GlcNAc metabolism.

Authors: Kan Liu; Andrew J Paterson; Fengxue Zhang; Joanne McAndrew; Ken-Ichiro Fukuchi; J Michael Wyss; Ling Peng; Yong Hu; Jeffrey E Kudlow
Journal: J Neurochem Date: 2004-05 Impact factor: 5.372

Review 3. O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress.

Authors: Natasha E Zachara; Gerald W Hart
Journal: Biochim Biophys Acta Date: 2004-07-06

4. The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny.

Authors: R Shafi; S P Iyer; L G Ellies; N O'Donnell; K W Marek; D Chui; G W Hart; J D Marth
Journal: Proc Natl Acad Sci U S A Date: 2000-05-23 Impact factor: 11.205

5. A Caenorhabditis elegans model of insulin resistance: altered macronutrient storage and dauer formation in an OGT-1 knockout.

Authors: John A Hanover; Michele E Forsythe; Patrick T Hennessey; Thomas M Brodigan; Dona C Love; Gilbert Ashwell; Michael Krause
Journal: Proc Natl Acad Sci U S A Date: 2005-07-28 Impact factor: 11.205

6. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.

Authors: L Bertram; D Blacker; K Mullin; D Keeney; J Jones; S Basu; S Yhu; M G McInnis; R C Go; K Vekrellis; D J Selkoe; A J Saunders; R E Tanzi
Journal: Science Date: 2000-12-22 Impact factor: 47.728

7. O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease.

Authors: Fei Liu; Khalid Iqbal; Inge Grundke-Iqbal; Gerald W Hart; Cheng-Xin Gong
Journal: Proc Natl Acad Sci U S A Date: 2004-07-12 Impact factor: 11.205

Review 8. Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications.

Authors: Daniel M Skovronsky; Virginia M-Y Lee; John Q Trojanowski
Journal: Annu Rev Pathol Date: 2006 Impact factor: 23.472

9. O-GlcNAc cycling mutants modulate proteotoxicity in Caenorhabditis elegans models of human neurodegenerative diseases.

Authors: Peng Wang; Brooke D Lazarus; Michele E Forsythe; Dona C Love; Michael W Krause; John A Hanover
Journal: Proc Natl Acad Sci U S A Date: 2012-09-17 Impact factor: 11.205

10. Repeated hypoxia exposure induces cognitive dysfunction, brain inflammation, and amyloidβ/p-Tau accumulation through reduced brain O-GlcNAcylation in zebrafish.

Authors: Jiwon Park; Sunhee Jung; Sang-Min Kim; In Young Park; Ngan An Bui; Geum-Sook Hwang; Inn-Oc Han
Journal: J Cereb Blood Flow Metab Date: 2021-06-26 Impact factor: 6.960

O-GlcNAc cycling modulates neurodegeneration.

1. Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting.

2. Accumulation of protein O-GlcNAc modification inhibits proteasomes in the brain and coincides with neuronal apoptosis in brain areas with high O-GlcNAc metabolism.

Review 3. O-GlcNAc a sensor of cellular state: the role of nucleocytoplasmic glycosylation in modulating cellular function in response to nutrition and stress.

4. The O-GlcNAc transferase gene resides on the X chromosome and is essential for embryonic stem cell viability and mouse ontogeny.

5. A Caenorhabditis elegans model of insulin resistance: altered macronutrient storage and dauer formation in an OGT-1 knockout.

6. Evidence for genetic linkage of Alzheimer's disease to chromosome 10q.

7. O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer's disease.

Review 8. Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications.

9. O-GlcNAc cycling mutants modulate proteotoxicity in Caenorhabditis elegans models of human neurodegenerative diseases.

10. Beta-amyloid precursor protein is modified with O-linked N-acetylglucosamine.

Review 1. The regulatory roles of O-GlcNAcylation in mitochondrial homeostasis and metabolic syndrome.

Review 2. Alzheimer disease therapeutics: focus on the disease and not just plaques and tangles.

Review 3. Regulation of protein degradation by O-GlcNAcylation: crosstalk with ubiquitination.

Review 4. Deregulation of brain insulin signaling in Alzheimer's disease.

5. O-GlcNAc cycling shows neuroprotective potential in C. elegans models of neurodegenerative disease.

6. O-GlcNAc profiling: from proteins to proteomes.

Review 7. O-GlcNAcase: promiscuous hexosaminidase or key regulator of O-GlcNAc signaling?

Review 8. O-GlcNAcylation: key regulator of glycolytic pathways.

9. Hyperphosphorylation-induced tau oligomers.

10. Repeated hypoxia exposure induces cognitive dysfunction, brain inflammation, and amyloidβ/p-Tau accumulation through reduced brain O-GlcNAcylation in zebrafish.