| Literature DB >> 23046699 |
Qiangde Duan1, Mingxu Zhou, Xiaofang Zhu, Yang Yang, Jun Zhu, Wenbin Bao, Shenglong Wu, Xiaosai Ruan, Weiping Zhang, Guoqiang Zhu.
Abstract
F18 fimbriae and toxins produced by F18 fimbriae-carrying Escherichia coli (E. coli) strains are known virulence factors responsible for post-weaning diarrhea (PWD) and edema disease (ED). In this study, we showed that fliC isogenic mutants constructed in two reference wild-type F18 fimbriae (F18+) E. coli were markedly impaired in adherence in vitro cell models (p < 0.05). Flagella purified from F18+E. coli could directly bind to cultured piglet epithelial cells and block adherence of F18+E. coli to cells when pre-incubated. In addition, the F18+E. coli fliC deletion mutants up-regulated the expression of type I fimbriae produced by F18+E. coli strains. These results demonstrated that expression of flagella is essential for the adherence of F18+E. coli in vitro.Entities:
Mesh：
Substances：
Year: 2012 PMID： 23046699 DOI： 10.1016/j.micpath.2012.09.010
Source DB: PubMed Journal: Microb Pathog ISSN： 0882-4010 Impact factor: 3.738