OBJECTIVE: While data on the relationship between fatty acid (FA) composition and the risk for total stroke have accumulated, the association between FA composition and the risk for intracranial atherosclerotic stenosis (ICAS) has never been studied. We compared plasma phospholipid FA composition between non-stroke control and ischemic stroke in Korean population, to discern the FA that distinguishes ICAS from total ischemic stroke patients. METHODS: Non-stroke controls (n = 215) and stroke patients (no cerebral atherosclerotic stenosis, NCAS: n = 144 and ICAS: n = 104) were finally included in the analysis. Plasma phospholipid FA compositions were analyzed. RESULTS: Age, coexistence of hypertension/diabetes were significantly different among the groups. Phospholipid FA compositions were significantly different between non-stroke control and ischemic stroke patients, and interestingly, between NCAS and ICAS in stroke patients. Pattern analysis showed that docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), the ω3-polyunsaturated FAs were important FAs in distinguishing NCAS and ICAS in strokes. Particularly, the risk of ICAS was inversely associated with levels of DHA contents in phospholipids (OR: 0.590, 95% CI: 0.350-0.993, p < 0.05), indicating that the risk may be increased at lower levels of DHA contents. CONCLUSION: DHA and EPA are important FAs for distinguishing NCAS and ICAS in strokes. Additionally, the risk of ICAS was inversely associated with the levels of phospholipid DHA, which indicates that sufficient amounts of DHA in plasma or in diet may reduce the risk of ICAS.
OBJECTIVE: While data on the relationship between fatty acid (FA) composition and the risk for total stroke have accumulated, the association between FA composition and the risk for intracranial atherosclerotic stenosis (ICAS) has never been studied. We compared plasma phospholipid FA composition between non-stroke control and ischemic stroke in Korean population, to discern the FA that distinguishes ICAS from total ischemic strokepatients. METHODS:Non-stroke controls (n = 215) and strokepatients (no cerebral atherosclerotic stenosis, NCAS: n = 144 and ICAS: n = 104) were finally included in the analysis. Plasma phospholipid FA compositions were analyzed. RESULTS: Age, coexistence of hypertension/diabetes were significantly different among the groups. Phospholipid FA compositions were significantly different between non-stroke control and ischemic strokepatients, and interestingly, between NCAS and ICAS in strokepatients. Pattern analysis showed that docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), the ω3-polyunsaturated FAs were important FAs in distinguishing NCAS and ICAS in strokes. Particularly, the risk of ICAS was inversely associated with levels of DHA contents in phospholipids (OR: 0.590, 95% CI: 0.350-0.993, p < 0.05), indicating that the risk may be increased at lower levels of DHA contents. CONCLUSION:DHA and EPA are important FAs for distinguishing NCAS and ICAS in strokes. Additionally, the risk of ICAS was inversely associated with the levels of phospholipidDHA, which indicates that sufficient amounts of DHA in plasma or in diet may reduce the risk of ICAS.
Authors: Claudia L Satizabal; Cécilia Samieri; Kendra L Davis-Plourde; Barbara Voetsch; Hugo J Aparicio; Matthew P Pase; José Rafael Romero; Catherine Helmer; Ramachandran S Vasan; Carlos S Kase; Stéphanie Debette; Alexa S Beiser; Sudha Seshadri Journal: Stroke Date: 2018-12 Impact factor: 7.914
Authors: Hamidreza Saber; Mohammad Yawar Yakoob; Peilin Shi; W T Longstreth; Rozenn N Lemaitre; David Siscovick; Kathryn M Rexrode; Walter C Willett; Dariush Mozaffarian Journal: Stroke Date: 2017-08-22 Impact factor: 7.914
Authors: Bart D Peters; Aristotle N Voineskos; Philip R Szeszko; Tristram A Lett; Pamela DeRosse; Saurav Guha; Katherine H Karlsgodt; Toshikazu Ikuta; Daniel Felsky; Majnu John; David J Rotenberg; James L Kennedy; Todd Lencz; Anil K Malhotra Journal: J Neurosci Date: 2014-04-30 Impact factor: 6.167