Literature DB >> 23042100

Enabling Wittig reaction on site-specific protein modification.

Ming-Jie Han1, De-Cai Xiong, Xin-Shan Ye.   

Abstract

An efficient aqueous Wittig reaction was enabled on protein bioconjugation for the first time. By investigating the reaction on small molecules, peptides, and proteins, a site-specific reaction targeting "aldehyde tag" was presented. A variety of functional groups could be introduced into the protein of interest.

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Year:  2012        PMID： 23042100     DOI： 10.1039/c2cc35738k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  5 in total

1.  A genetically encoded aldehyde for rapid protein labelling.

Authors:  Alfred Tuley; Yan-Jiun Lee; Bo Wu; Zhiyong U Wang; Wenshe R Liu
Journal:  Chem Commun (Camb)       Date:  2014-07-18       Impact factor: 6.222

2.  Amino-Acid-Catalyzed Direct Aldol Bioconjugation.

Authors:  Tiauna S Howard; Ryan D Cohen; Ogonna Nwajiobi; Zilma P Muneeswaran; Yonnette E Sim; Neelam N Lahankar; Johannes T-H Yeh; Monika Raj
Journal:  Org Lett       Date:  2018-08-20       Impact factor: 6.005

Review 3.  Bioorthogonal chemistry: strategies and recent developments.

Authors:  Carlo P Ramil; Qing Lin
Journal:  Chem Commun (Camb)       Date:  2013-12-07       Impact factor: 6.222

4.  Synthesis of phosphine oxide based amphiphilic molecules via ring-opening Wittig olefination of a macrocyclic phosphoranylidene and their property study as non-ionic surfactants.

Authors:  Jin Xu; Anqi Chen; Brendan Burkett; Qi Hua Ng; Kok Ping Chan
Journal:  RSC Adv       Date:  2018-06-05       Impact factor: 3.361

5.  Bifunctional Reagents for Formylglycine Conjugation: Pitfalls and Breakthroughs.

Authors:  Nils Janson; Tobias Krüger; Lennard Karsten; Mareile Boschanski; Thomas Dierks; Kristian M Müller; Norbert Sewald
Journal:  Chembiochem       Date:  2020-09-18       Impact factor: 3.164
  5 in total

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