OBJECTIVE: To prospectively examine the prevalence of hypovitaminosis D in pregnancy and to correlate maternal and fetal vitamin D to fetal anthropometry. DESIGN: A prospective cohort study. SETTING: Tertiary referral maternity hospital. PATIENT(S): Sixty pregnant women. INTERVENTION(S): Serum 25-hydroxyvitamin D (25OHD) was measured in early pregnancy, at 28 weeks, and in cord blood at delivery. MAIN OUTCOME MEASURE(S): The prevalence of hypovitaminosis D and the relationship between fetal growth and serum 25OHD concentrations. RESULT(S): Two subgroups were analyzed to examine results in the context of seasonal variation in 25OHD: a winter and a summer cohort. Fetal anthropometry was assessed at 20 and 34 weeks, and at delivery the neonatal anthropometry was recorded. There was a high prevalence of hypovitaminosis D ranging from 33% to 97%, with a marked seasonal variation. Fetal 25OHD concentrations correlated with all biometry at 20 weeks. In the winter cohort, a correlation was found between early pregnancy 25OHD and femur length at 20 weeks, and between 28-week 25OHD and femur length at 34 weeks. Infant length was shorter in those with early pregnancy 25OHD less than the median (52.1 vs. 53.6 cm). CONCLUSION(S): The high prevalence of maternal hypovitaminosis D during winter months in northern latitudes may have detrimental effects on fetal skeletal growth.
OBJECTIVE: To prospectively examine the prevalence of hypovitaminosis D in pregnancy and to correlate maternal and fetal vitamin D to fetal anthropometry. DESIGN: A prospective cohort study. SETTING: Tertiary referral maternity hospital. PATIENT(S): Sixty pregnant women. INTERVENTION(S): Serum 25-hydroxyvitamin D (25OHD) was measured in early pregnancy, at 28 weeks, and in cord blood at delivery. MAIN OUTCOME MEASURE(S): The prevalence of hypovitaminosis D and the relationship between fetal growth and serum 25OHD concentrations. RESULT(S): Two subgroups were analyzed to examine results in the context of seasonal variation in 25OHD: a winter and a summer cohort. Fetal anthropometry was assessed at 20 and 34 weeks, and at delivery the neonatal anthropometry was recorded. There was a high prevalence of hypovitaminosis D ranging from 33% to 97%, with a marked seasonal variation. Fetal 25OHD concentrations correlated with all biometry at 20 weeks. In the winter cohort, a correlation was found between early pregnancy 25OHD and femur length at 20 weeks, and between 28-week 25OHD and femur length at 34 weeks. Infant length was shorter in those with early pregnancy 25OHD less than the median (52.1 vs. 53.6 cm). CONCLUSION(S): The high prevalence of maternal hypovitaminosis D during winter months in northern latitudes may have detrimental effects on fetal skeletal growth.
Authors: Maeve Smith; Eileen C O'Brien; Goiuri Alberdi; Aisling A Geraghty; Mark Kilbane; Malachi J McKenna; Fionnuala M McAuliffe Journal: Ir J Med Sci Date: 2019-08-29 Impact factor: 1.568
Authors: Spyridon N Karras; Hana Fakhoury; Giovanna Muscogiuri; William B Grant; Johannes M van den Ouweland; Anna Maria Colao; Kalliopi Kotsa Journal: Ther Adv Musculoskelet Dis Date: 2016-07-13 Impact factor: 5.346
Authors: E Morales; A Rodriguez; D Valvi; C Iñiguez; A Esplugues; J Vioque; L S Marina; A Jiménez; M Espada; C R Dehli; A Fernández-Somoano; M Vrijheid; J Sunyer Journal: Int J Obes (Lond) Date: 2014-09-05 Impact factor: 5.095
Authors: Yi Lin Ong; Phaik Ling Quah; Mya Thway Tint; Izzuddin M Aris; Ling Wei Chen; Rob M van Dam; Denise Heppe; Seang-Mei Saw; Keith M Godfrey; Peter D Gluckman; Yap Seng Chong; Fabian Yap; Yung Seng Lee; Mary Foong-Fong Chong Journal: Br J Nutr Date: 2016-06-24 Impact factor: 3.718