Literature DB >> 2303782

The chromosome translocation (11;14)(p13;q11) associated with T cell acute leukemia. Asymmetric diversification of the translocational junctions.

J T Cheng1, C Y Yang, J Hernandez, J Embrey, R Baer.   

Abstract

The t(11;14)(p13;q13) translocation associated with T cell acute lymphocytic leukemia generates two abnormal chromosomes, designated 11p+ and 14q-. To investigate the mechanism of t(11;14)(p13;q11) formation, we analyzed the translocation junctions of 11p+ and 14q- from two patients. The 11p+ junctions consisted of precise fusions of a pseudo recombination signal from chromosome 11 and the downstream recombination signal of the TCR D delta 2 gene segment from chromosome 14. In contrast, the 14q- junctions from both patients were diversified by random loss and addition of nucleotides at the translocation site. This asymmetric pattern of junctional diversification is typical of normal Ig/TCR gene rearrangement, and therefore implies that the t(11;14)(p13;q11) translocation arose due to aberrant activity of the Ig/TCR recombinase.

Entities:  

Mesh：

Year:  1990        PMID： 2303782      PMCID： PMC2187731          DOI： 10.1084/jem.171.2.489

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  39 in total

1.  The chromosome translocation (11;14)(p13;q11) associated with T-cell acute lymphocytic leukemia: an 11p13 breakpoint cluster region.

Authors:  G Yoffe; N Schneider; L Van Dyk; C Y Yang; M Siciliano; G Buchanan; J D Capra; R Baer
Journal:  Blood       Date:  1989-07       Impact factor: 22.113

2.  Lymphoid V(D)J recombination: nucleotide insertion at signal joints as well as coding joints.

Authors:  M R Lieber; J E Hesse; K Mizuuchi; M Gellert
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

3.  Genomic organization of the human T-cell antigen-receptor alpha/delta locus.

Authors:  K Satyanarayana; S Hata; P Devlin; M G Roncarolo; J E De Vries; H Spits; J L Strominger; M S Krangel
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

4.  The defect in murine severe combined immune deficiency: joining of signal sequences but not coding segments in V(D)J recombination.

Authors:  M R Lieber; J E Hesse; S Lewis; G C Bosma; N Rosenberg; K Mizuuchi; M J Bosma; M Gellert
Journal:  Cell       Date:  1988-10-07       Impact factor: 41.582

5.  Chicken IgL gene rearrangement involves deletion of a circular episome and addition of single nonrandom nucleotides to both coding segments.

Authors:  W T McCormack; L W Tjoelker; L M Carlson; B Petryniak; C F Barth; E H Humphries; C B Thompson
Journal:  Cell       Date:  1989-03-10       Impact factor: 41.582

6.  The T-cell receptor delta chain locus is disrupted in the T-ALL associated t(11;14)(p13;q11) translocation.

Authors:  E Champagne; Y Takihara; U Sagman; J de Sousa; S Burrow; W H Lewis; T W Mak; M D Minden
Journal:  Blood       Date:  1989-05-01       Impact factor: 22.113

7.  Human T-cell antigen receptor (TCR) delta-chain locus and elements responsible for its deletion are within the TCR alpha-chain locus.

Authors:  R D Hockett; J P de Villartay; K Pollock; D G Poplack; D I Cohen; S J Korsmeyer
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

8.  Complex rearrangements within the human J delta-C delta/J alpha-C alpha locus and aberrant recombination between J alpha segments.

Authors:  R Baer; T Boehm; H Yssel; H Spits; T H Rabbitts
Journal:  EMBO J       Date:  1988-06       Impact factor: 11.598

9.  Isolation of scid pre-B cells that rearrange kappa light chain genes: formation of normal signal and abnormal coding joins.

Authors:  T K Blackwell; B A Malynn; R R Pollock; P Ferrier; L R Covey; G M Fulop; R A Phillips; G D Yancopoulos; F W Alt
Journal:  EMBO J       Date:  1989-03       Impact factor: 11.598

10.  Consistent breakage between consensus recombinase heptamers of chromosome 9 DNA in a recurrent chromosomal translocation of human T cell leukemia.

Authors:  B Tycko; T C Reynolds; S D Smith; J Sklar
Journal:  J Exp Med       Date:  1989-02-01       Impact factor: 14.307
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  12 in total

Review 1.  Breakpoint sites disclose the role of the V(D)J recombination machinery in the formation of T-cell receptor (TCR) and non-TCR associated aberrations in T-cell acute lymphoblastic leukemia.

Authors:  Nicole S D Larmonie; Willem A Dik; Jules P P Meijerink; Irene Homminga; Jacques J M van Dongen; Anton W Langerak
Journal:  Haematologica       Date:  2013-08       Impact factor: 9.941

2.  Cryptic signals and the fidelity of V(D)J joining.

Authors:  S M Lewis; E Agard; S Suh; L Czyzyk
Journal:  Mol Cell Biol       Date:  1997-06       Impact factor: 4.272

3.  TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia.

Authors:  Y Xia; L Brown; C Y Yang; J T Tsan; M J Siciliano; R Espinosa; M M Le Beau; R J Baer
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

4.  Molecular involvement of the pvt-1 locus in a gamma/delta T-cell leukemia bearing a variant t(8;14)(q24;q11) translocation.

Authors:  M Kasai; R T Maziarz; K Aoki; E Macintyre; J L Strominger
Journal:  Mol Cell Biol       Date:  1992-10       Impact factor: 4.272

5.  Acute leukemias of different lineages have similar MLL gene fusions encoding related chimeric proteins resulting from chromosomal translocation.

Authors:  J Corral; A Forster; S Thompson; F Lampert; Y Kaneko; R Slater; W G Kroes; C E van der Schoot; W D Ludwig; A Karpas
Journal:  Proc Natl Acad Sci U S A       Date:  1993-09-15       Impact factor: 11.205

6.  Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia.

Authors:  L Brown; J T Cheng; Q Chen; M J Siciliano; W Crist; G Buchanan; R Baer
Journal:  EMBO J       Date:  1990-10       Impact factor: 11.598

7.  V(D)J-mediated translocations in lymphoid neoplasms: a functional assessment of genomic instability by cryptic sites.

Authors:  Rodrig Marculescu; Trang Le; Paul Simon; Ulrich Jaeger; Bertrand Nadel
Journal:  J Exp Med       Date:  2002-01-07       Impact factor: 14.307

8.  BCL2 oncogene translocation is mediated by a chi-like consensus.

Authors:  R T Wyatt; R A Rudders; A Zelenetz; R A Delellis; T G Krontiris
Journal:  J Exp Med       Date:  1992-06-01       Impact factor: 14.307

9.  In vivo reinsertion of excised episomes by the V(D)J recombinase: a potential threat to genomic stability.

Authors:  Katrina Vanura; Bertrand Montpellier; Trang Le; Salvatore Spicuglia; Jean-Marc Navarro; Olivier Cabaud; Sandrine Roulland; Elodie Vachez; Immo Prinz; Pierre Ferrier; Rodrig Marculescu; Ulrich Jäger; Bertrand Nadel
Journal:  PLoS Biol       Date:  2007-03       Impact factor: 8.029

10.  Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.

Authors:  I Wadman; J Li; R O Bash; A Forster; H Osada; T H Rabbitts; R Baer
Journal:  EMBO J       Date:  1994-10-17       Impact factor: 11.598
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