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Literature DB >> 23032787

The G0/G1 switch gene 2 (G0S2): regulating metabolism and beyond.

Bradlee L Heckmann¹, Xiaodong Zhang, Xitao Xie, Jun Liu.

Abstract

The G0/G1 switch gene 2 (G0S2) was originally identified in blood mononuclear cells following induced cell cycle progression. Translation of G0S2 results in a small basic protein of 103 amino acids in size. It was initially believed that G0S2 mediates re-entry of cells from the G0 to G1 phase of the cell cycle. Recent studies have begun to reveal the functional aspects of G0S2 and its protein product in various cellular settings. To date the best-known function of G0S2 is its direct inhibitory capacity on the rate-limiting lipolytic enzyme adipose triglyceride lipase (ATGL). Other studies have illustrated key features of G0S2 including sub-cellular localization, expression profiles and regulation, and possible functions in cellular proliferation and differentiation. In this review we present the current knowledge base regarding all facets of G0S2, and pose a variety of questions and hypotheses pertaining to future research directions.

Entities: CellLine Chemical Disease Gene Mutation Species

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Year: 2012 PMID： 23032787 PMCID： PMC3698047 DOI： 10.1016/j.bbalip.2012.09.016

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

74 in total

1. The effect of short-term fasting on liver and skeletal muscle lipid, glucose, and energy metabolism in healthy women and men.

Authors: Jeffrey D Browning; Jeannie Baxter; Santhosh Satapati; Shawn C Burgess
Journal: J Lipid Res Date: 2011-12-03 Impact factor: 5.922

2. Gene expression profiling of acute graft-vs-host disease after hematopoietic stem cell transplantation.

Authors: Jan Verner; Jitka Kabathova; Alexandra Tomancova; Sarka Pavlova; Boris Tichy; Marek Mraz; Yvona Brychtova; Marta Krejci; Zbynek Zdrahal; Martin Trbusek; Jana Volejnikova; Petr Sedlacek; Michael Doubek; Jiri Mayer; Sarka Pospisilova
Journal: Exp Hematol Date: 2012-07-04 Impact factor: 3.084

3. Reduced mRNA and protein expression of perilipin A and G0/G1 switch gene 2 (G0S2) in human adipose tissue in poorly controlled type 2 diabetes.

Authors: Thomas S Nielsen; Ulla Kampmann; Roni R Nielsen; Niels Jessen; Lotte Orskov; Steen B Pedersen; Jens O Jørgensen; Sten Lund; Niels Møller
Journal: J Clin Endocrinol Metab Date: 2012-04-24 Impact factor: 5.958

4. Inverse regulation of basal lipolysis in perigonadal and mesenteric fat depots in mice.

Authors: Stephan Wueest; Xingyuan Yang; Jun Liu; Eugen J Schoenle; Daniel Konrad
Journal: Am J Physiol Endocrinol Metab Date: 2011-10-11 Impact factor: 4.310

5. Relative contribution of adipose triglyceride lipase and hormone-sensitive lipase to tumor necrosis factor-α (TNF-α)-induced lipolysis in adipocytes.

Authors: Xingyuan Yang; Xiaodong Zhang; Bradlee L Heckmann; Xin Lu; Jun Liu
Journal: J Biol Chem Date: 2011-10-03 Impact factor: 5.157

6. G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase.

Authors: Martina Schweiger; Margret Paar; Christina Eder; Janina Brandis; Elena Moser; Gregor Gorkiewicz; Susanne Grond; Franz P W Radner; Ines Cerk; Irina Cornaciu; Monika Oberer; Sander Kersten; Rudolf Zechner; Robert Zimmermann; Achim Lass
Journal: J Lipid Res Date: 2012-08-13 Impact factor: 5.922

7. Epidermolysis bullosa - a group of skin diseases with different causes but commonalities in gene expression.

Authors: Julia Knaup; Thomas Verwanger; Christina Gruber; Verena Ziegler; Johann W Bauer; Barbara Krammer
Journal: Exp Dermatol Date: 2012-07 Impact factor: 3.960

8. The cytosolic protein G0S2 maintains quiescence in hematopoietic stem cells.

Authors: Takeshi Yamada; Chun Shik Park; Audrea Burns; Daisuke Nakada; H Daniel Lacorazza
Journal: PLoS One Date: 2012-05-31 Impact factor: 3.240

9. ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1.

Authors: Guenter Haemmerle; Tarek Moustafa; Gerald Woelkart; Sabrina Büttner; Albrecht Schmidt; Tineke van de Weijer; Matthijs Hesselink; Doris Jaeger; Petra C Kienesberger; Kathrin Zierler; Renate Schreiber; Thomas Eichmann; Dagmar Kolb; Petra Kotzbeck; Martina Schweiger; Manju Kumari; Sandra Eder; Gabriele Schoiswohl; Nuttaporn Wongsiriroj; Nina M Pollak; Franz P W Radner; Karina Preiss-Landl; Thomas Kolbe; Thomas Rülicke; Burkert Pieske; Michael Trauner; Achim Lass; Robert Zimmermann; Gerald Hoefler; Saverio Cinti; Erin E Kershaw; Patrick Schrauwen; Frank Madeo; Bernd Mayer; Rudolf Zechner
Journal: Nat Med Date: 2011-08-21 Impact factor: 87.241

10. The minimal domain of adipose triglyceride lipase (ATGL) ranges until leucine 254 and can be activated and inhibited by CGI-58 and G0S2, respectively.

Authors: Irina Cornaciu; Andras Boeszoermenyi; Hanna Lindermuth; Harald M Nagy; Ines K Cerk; Catharina Ebner; Barbara Salzburger; Astrid Gruber; Martina Schweiger; Rudolf Zechner; Achim Lass; Robert Zimmermann; Monika Oberer
Journal: PLoS One Date: 2011-10-19 Impact factor: 3.240

49 in total

1. Regulation of fibroblast lipid storage and myofibroblast phenotypes during alveolar septation in mice.

Authors: Stephen E McGowan; Diann M McCoy
Journal: Am J Physiol Lung Cell Mol Physiol Date: 2014-08-22 Impact factor: 5.464

2. Integrated Regulation of Hepatic Lipid and Glucose Metabolism by Adipose Triacylglycerol Lipase and FoxO Proteins.

Authors: Wenwei Zhang; So Young Bu; Mara T Mashek; InSug O-Sullivan; Zakaria Sibai; Salmaan A Khan; Olga Ilkayeva; Christopher B Newgard; Douglas G Mashek; Terry G Unterman
Journal: Cell Rep Date: 2016-03-31 Impact factor: 9.423

3. The sparing use of fat: G0s2 controls lipolysis and fatty acid oxidation.

Authors: Christoph Heier; Robert Zimmermann
Journal: Diabetologia Date: 2014-10-29 Impact factor: 10.122

4. G0S2 represses PI3K/mTOR signaling and increases sensitivity to PI3K/mTOR pathway inhibitors in breast cancer.

Authors: Christina Y Yim; Emmanuel Bikorimana; Ema Khan; Joshua M Warzecha; Leah Shin; Jennifer Rodriguez; Ethan Dmitrovsky; Sarah J Freemantle; Michael J Spinella
Journal: Cell Cycle Date: 2017-09-14 Impact factor: 4.534

5. G0S2--a new player in leukemia.

Authors: Kimberly J Payne; Sinisa Dovat
Journal: Leuk Res Date: 2013-11-24 Impact factor: 3.156

6. Tissue-Specific and Genetic Regulation of Insulin Sensitivity-Associated Transcripts in African Americans.

Authors: Neeraj K Sharma; Satria P Sajuthi; Jeff W Chou; Jorge Calles-Escandon; Jamehl Demons; Samantha Rogers; Lijun Ma; Nicholette D Palmer; David R McWilliams; John Beal; Mary E Comeau; Kristina Cherry; Gregory A Hawkins; Lata Menon; Ethel Kouba; Donna Davis; Marcie Burris; Sara J Byerly; Linda Easter; Donald W Bowden; Barry I Freedman; Carl D Langefeld; Swapan K Das
Journal: J Clin Endocrinol Metab Date: 2016-01-20 Impact factor: 5.958

7. Transcriptional profiles of JIA patient blood with subsequent poor response to methotrexate.

Authors: Halima Moncrieffe; Mark F Bennett; Monica Tsoras; Lorie K Luyrink; Anne L Johnson; Huan Xu; Jason Dare; Mara L Becker; Sampath Prahalad; Margalit Rosenkranz; Kathleen M O'Neil; Peter A Nigrovic; Thomas A Griffin; Daniel J Lovell; Alexei A Grom; Mario Medvedovic; Susan D Thompson
Journal: Rheumatology (Oxford) Date: 2017-09-01 Impact factor: 7.580