Literature DB >> 2302686

Trisomy 12 in uterine leiomyomas. A new cytogenetic subgroup.

M Nilbert1, S Heim, N Mandahl, U M Flodérus, H Willén, F Mitelman.   

Abstract

Chromosome analysis of short-term cultures from uterine leiomyomas revealed trisomy 12 in six cases. In four of the tumors + 12 was the only karyotypic change. The fifth case also had trisomy 4, whereas the sixth had loss of one X chromosome as an additional aberration. These findings indicate that trisomy 12 characterizes a new cytogenetic subgroup of uterine leiomyoma.

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Year:  1990        PMID： 2302686     DOI： 10.1016/0165-4608(90)90067-k

Source DB:  PubMed          Journal:  Cancer Genet Cytogenet        ISSN： 0165-4608


  9 in total

1.  Characteristic chromosome abnormalities, including rearrangements of 6p, del(7q), +12, and t(12;14), in 44 uterine leiomyomas.

Authors:  M Nilbert; S Heim; N Mandahl; U M Flodérus; H Willén; F Mitelman
Journal:  Hum Genet       Date:  1990-10       Impact factor: 4.132

2.  Ovarian granulosa-stromal cell tumors are characterized by trisomy 12.

Authors:  J A Fletcher; Z Gibas; K Donovan; A Perez-Atayde; D Genest; C C Morton; J M Lage
Journal:  Am J Pathol       Date:  1991-03       Impact factor: 4.307

3.  Frequent loss of heterozygosity for chromosome 10 in uterine leiomyosarcoma in contrast to leiomyoma.

Authors:  B J Quade; A P Pinto; D R Howard; W A Peters; C P Crum
Journal:  Am J Pathol       Date:  1999-03       Impact factor: 4.307

4.  Cytogenetic analyses of secondary liver tumors reveal significant differences in genomic imbalances between primary and metastatic colon carcinomas.

Authors:  L A Parada; A Marañon; M Hallén; K G Tranberg; U Stenram; G Bardi; B Johansson
Journal:  Clin Exp Metastasis       Date:  1999       Impact factor: 5.150

5.  A Novel Cryptic t(2;3)(p21;q25) Translocation Fuses the WWTR1 and PRKCE Genes in Uterine Leiomyoma With 3q- as the Sole Visible Chromosome Abnormality.

Authors:  Ioannis Panagopoulos; Kristin Andersen; Ludmila Gorunova; Ben Davidson; Francesca Micci; Sverre Heim
Journal:  Cancer Genomics Proteomics       Date:  2022 Sep-Oct       Impact factor: 3.395

6.  Interphase molecular cytogenetic analysis of epithelial ovarian carcinomas.

Authors:  D L Persons; L C Hartmann; J F Herath; T J Borell; W A Cliby; G L Keeney; R B Jenkins
Journal:  Am J Pathol       Date:  1993-03       Impact factor: 4.307

7.  An unusual karyotype in leiomyoma: Case report and literature review.

Authors:  Le Chang; Nagesh Rao; Nicholas Bernthal; Sarah M Dry; Aaron W James
Journal:  J Orthop       Date:  2015-11-02

8.  Consistent numerical chromosome aberrations in thecofibromas of the ovary.

Authors:  Francesca Micci; Lisbeth Haugom; Vera M Abeler; Claes G Tropé; Håvard E Danielsen; Sverre Heim
Journal:  Virchows Arch       Date:  2008-03       Impact factor: 4.064

9.  Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas.

Authors:  Megan M McGuire; Alexander Yatsenko; Lori Hoffner; Mirka Jones; Urvashi Surti; Aleksandar Rajkovic
Journal:  PLoS One       Date:  2012-03-12       Impact factor: 3.240
  9 in total

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