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Literature DB >> 2000932

Ovarian granulosa-stromal cell tumors are characterized by trisomy 12.

J A Fletcher¹, Z Gibas, K Donovan, A Perez-Atayde, D Genest, C C Morton, J M Lage.

Abstract

Eleven ovarian granulosa-stromal cell tumors including 1 thecoma, 2 fibromas, 6 fibrothecomas, and 2 granulosa cell tumors, were karyotyped after direct harvest and/or short-term tissue culture. Bilateral fibrothecomas from one patient appeared to lack cytogenetic aberrations: the remaining nine tumors were characterized by trisomy for chromosome 12. Cytogenetic aberrations in the two granulosa cell tumors were much less complex than those described previously in undifferentiated carcinomas; accordingly cytogenetic analyses might be useful in distinguishing these categories. The consistent occurrence of trisomy 12 in different varieties of granulosa-stromal cell tumors suggests a common mechanism of oncogenesis within this diverse group of neoplasms. That mechanism probably involves promotion of low-grade, orderly cell proliferation.

Entities: Disease Species

Mesh：

Substances：
DNA

Year: 1991 PMID： 2000932 PMCID： PMC1886274

Source DB: PubMed Journal: Am J Pathol ISSN： 0002-9440 Impact factor: 4.307

19 in total

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2. Cytogenetic findings and prognosis in neuroblastoma with emphasis on marker chromosome 1.

Authors: Y Hayashi; N Kanda; T Inaba; R Hanada; N Nagahara; H Muchi; K Yamamoto
Journal: Cancer Date: 1989-01-01 Impact factor: 6.860

3. Prognostic importance of structural chromosomal abnormalities in children with hyperdiploid (greater than 50 chromosomes) acute lymphoblastic leukemia.

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Journal: Blood Date: 1989-05-15 Impact factor: 22.113

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Authors: J R Teyssier; J J Adnet; F Pigeon; F Bajolle
Journal: Cancer Genet Cytogenet Date: 1985-01-01

5. Limits of detection of nuclear DNA abnormalities by flow cytometric DNA analysis. Results obtained by a set of methods for sample-storage, staining and internal standardization.

Authors: L L Vindeløv; I J Christensen; G Jensen; N I Nissen
Journal: Cytometry Date: 1983-03

6. Application of long-term collagenase disaggregation for the cytogenetic analysis of human solid tumors.

Authors: J Limon; P Dal Cin; A A Sandberg
Journal: Cancer Genet Cytogenet Date: 1986-12

7. Prognostic subgroups in B-cell chronic lymphocytic leukemia defined by specific chromosomal abnormalities.

Authors: G Juliusson; D G Oscier; M Fitchett; F M Ross; G Stockdill; M J Mackie; A C Parker; G L Castoldi; A Guneo; S Knuutila; E Elonen; G Gahrton
Journal: N Engl J Med Date: 1990-09-13 Impact factor: 91.245

8. Trisomy 12 is a consistent chromosomal aberration in benign ovarian tumors.

Authors: T Pejovic; S Heim; N Mandahl; B Elmfors; U M Flodérus; S Furgyik; G Helm; H Willén; F Mitelman
Journal: Genes Chromosomes Cancer Date: 1990-05 Impact factor: 5.006

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Authors: Y Kaneko; N Kanda; N Maseki; M Sakurai; Y Tsuchida; T Takeda; I Okabe; M Sakurai
Journal: Cancer Res Date: 1987-01-01 Impact factor: 12.701

10. Flow cytometric DNA ploidy analysis of ovarian granulosa cell tumors.

Authors: S Chadha; C J Cornelisse; A Schaberg
Journal: Gynecol Oncol Date: 1990-02 Impact factor: 5.482

9 in total

1. Establishment and characterization of a novel uterine carcinosarcoma cell line, TU-ECS-1, with mutations of TP53 and KRAS.

Authors: Yohei Chiba; Seiya Sato; Hiroaki Itamochi; Yasuko Suga; Tomoyuki Fukagawa; Nao Oumi; Tetsuro Oishi; Tasuku Harada; Tamotsu Sugai; Toru Sugiyama
Journal: Hum Cell Date: 2016-11-26 Impact factor: 4.174

2. Terminal differentiation of human liposarcoma cells induced by ligands for peroxisome proliferator-activated receptor gamma and the retinoid X receptor.

Authors: P Tontonoz; S Singer; B M Forman; P Sarraf; J A Fletcher; C D Fletcher; R P Brun; E Mueller; S Altiok; H Oppenheim; R M Evans; B M Spiegelman
Journal: Proc Natl Acad Sci U S A Date: 1997-01-07 Impact factor: 11.205

3. Imbalances of chromosomes 4, 9, and 12 are recurrent in the thecoma-fibroma group of ovarian stromal tumors.

Authors: Renae C Streblow; Alicia J Dafferner; Marilu Nelson; Mavis Fletcher; William W West; Rachel K Stevens; Zoran Gatalica; Deborah Novak; Julia A Bridge
Journal: Cancer Genet Cytogenet Date: 2007-10-15

4. Assessment of proliferative activity in ovarian neoplasms by flow and static cytometry. Correlation with prognostic features.

Authors: P C Huettner; D S Weinberg; J M Lage
Journal: Am J Pathol Date: 1992-09 Impact factor: 4.307

5. Trisomy 12 in pediatric granulosa-stromal cell tumors. Demonstration by a modified method of fluorescence in situ hybridization on paraffin-embedded material.

Authors: D E Schofield; J A Fletcher
Journal: Am J Pathol Date: 1992-12 Impact factor: 4.307