Literature DB >> 23026223

A new automated NaCl based robust method for routine production of gallium-68 labeled peptides.

Michael K Schultz1, Dirk Mueller, Richard P Baum, G Leonard Watkins, Wouter A P Breeman.   

Abstract

A new NaCl based method for preparation of gallium-68 labeled radiopharmaceuticals has been adapted for use with an automated gallium-68 generator system. The method was evaluated based on 56 preparations of [(68)Ga]DOTATOC and compared to a similar acetone-based approach. Advantages of the new NaCl approach include reduced preparation time (<15 min) and removal of organic solvents. The method produces high peptide-bound % (>97%), and specific activity (>40 MBq nmole(-1) [(68)Ga]DOTATOC) and is well-suited for clinical production of radiopharmaceuticals.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 23026223      PMCID： PMC5506834          DOI： 10.1016/j.apradiso.2012.08.011

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  13 in total

1.  Automated module radiolabeling of peptides and antibodies with gallium-68, lutetium-177 and iodine-131.

Authors:  Mario De Decker; J Harvey Turner
Journal:  Cancer Biother Radiopharm       Date:  2011-12-07       Impact factor: 3.099

Review 2.  Gallium-68: a new trend in PET radiopharmacy.

Authors:  M Isabel M Prata
Journal:  Curr Radiopharm       Date:  2012-04

Review 3.  The renaissance of the ⁶⁸Ge/⁶⁸Ga radionuclide generator initiates new developments in ⁶⁸Ga radiopharmaceutical chemistry.

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4.  Radiolabelling DOTA-peptides with 68Ga.

Authors:  Wouter A P Breeman; Marion de Jong; Erik de Blois; Bert F Bernard; Mark Konijnenberg; Eric P Krenning
Journal:  Eur J Nucl Med Mol Imaging       Date:  2005-01-18       Impact factor: 9.236

Review 5.  Radiopharmaceutical development of radiolabelled peptides.

Authors:  Melpomeni Fani; Helmut R Maecke
Journal:  Eur J Nucl Med Mol Imaging       Date:  2012-02       Impact factor: 9.236

6.  Cost comparison of 111In-DTPA-octreotide scintigraphy and 68Ga-DOTATOC PET/CT for staging enteropancreatic neuroendocrine tumours.

Authors:  Nils F Schreiter; Winfried Brenner; Munenobu Nogami; Ralph Buchert; Alexander Huppertz; Ulrich-Frank Pape; Vikas Prasad; Bernd Hamm; Martin H Maurer
Journal:  Eur J Nucl Med Mol Imaging       Date:  2011-09-17       Impact factor: 9.236

7.  Simplified NaCl based (68)Ga concentration and labeling procedure for rapid synthesis of (68)Ga radiopharmaceuticals in high radiochemical purity.

Authors:  Dirk Mueller; Ingo Klette; Richard P Baum; M Gottschaldt; Michael K Schultz; Wouter A P Breeman
Journal:  Bioconjug Chem       Date:  2012-07-19       Impact factor: 4.774

8.  Processing of generator-produced 68Ga for medical application.

Authors:  Konstantin P Zhernosekov; Dimitry V Filosofov; Richard P Baum; Peter Aschoff; Heiner Bihl; Anatoli A Razbash; Markus Jahn; Mark Jennewein; Frank Rösch
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Review 9.  Radiometallo-labeled peptides in tumor diagnosis and therapy.

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Journal:  Met Ions Biol Syst       Date:  2004

10.  Radiation exposure to nuclear medicine personnel handling positron emitters from Ge-68/Ga-68 generator.

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Journal:  Indian J Nucl Med       Date:  2011-04
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  15 in total

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Authors:  Yusuf Menda; Thomas M O'Dorisio; James R Howe; Michael Schultz; Joseph S Dillon; David Dick; G Leonard Watkins; Timothy Ginader; David L Bushnell; John J Sunderland; Gideon K D Zamba; Michael Graham; M Sue O'Dorisio
Journal:  J Nucl Med       Date:  2017-02-02       Impact factor: 10.057

Review 2.  68Ga-DOTA and analogs: Current status and future perspectives.

Authors:  Krzysztof Kilian
Journal:  Rep Pract Oncol Radiother       Date:  2014-05-19

3.  First-In-Human Study Demonstrating Tumor-Angiogenesis by PET/CT Imaging with (68)Ga-NODAGA-THERANOST, a High-Affinity Peptidomimetic for αvβ3 Integrin Receptor Targeting.

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Journal:  Cancer Biother Radiopharm       Date:  2015-05       Impact factor: 3.099

4.  Optimization of a Labeling and Kit Preparation Method for Ga-68 Labeled DOTATATE, Using Cation Exchange Resin Purified Ga-68 Eluates Obtained from a Tin Dioxide 68Ge/68Ga Generator.

Authors:  Deidré Prince; Daniel Rossouw; Sietske Rubow
Journal:  Mol Imaging Biol       Date:  2018-12       Impact factor: 3.488

5.  Repeatability of gallium-68 DOTATOC positron emission tomographic imaging in neuroendocrine tumors.

Authors:  Yusuf Menda; Laura L Boles Ponto; Michael K Schultz; Gideon K D Zamba; G Leonard Watkins; David L Bushnell; Mark T Madsen; John J Sunderland; Michael M Graham; Thomas M O'Dorisio; M Sue O'Dorisio
Journal:  Pancreas       Date:  2013-08       Impact factor: 3.327

6.  Radiolabeling optimization and characterization of (68)Ga labeled DOTA-polyamido-amine dendrimer conjugate - Animal biodistribution and PET imaging results.

Authors:  Aanchal Ghai; Baljinder Singh; Puja Panwar Hazari; Michael K Schultz; Ambika Parmar; Pardeep Kumar; Sarika Sharma; Devinder Dhawan; Anil Kumar Mishra
Journal:  Appl Radiat Isot       Date:  2015-07-22       Impact factor: 1.513

7.  Radiosynthesis of clinical doses of ⁶⁸Ga-DOTATATE (GalioMedix™) and validation of organic-matrix-based ⁶⁸Ge/⁶⁸Ga generators.

Authors:  Izabela Tworowska; David Ranganathan; Sanjay Thamake; Ebrahim Delpassand; Alireza Mojtahedi; Michael K Schultz; Konstantin Zhernosekov; Sebastian Marx
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8.  Evaluation of a PACAP Peptide Analogue Labeled with (68)Ga Using Two Different Chelating Agents.

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Journal:  Cancer Biother Radiopharm       Date:  2016-02       Impact factor: 3.099

Review 9.  Prospective of ⁶⁸Ga-radiopharmaceutical development.

Authors:  Irina Velikyan
Journal:  Theranostics       Date:  2013-12-10       Impact factor: 11.556

10.  Novel Preclinical and Radiopharmaceutical Aspects of [68Ga]Ga-PSMA-HBED-CC: A New PET Tracer for Imaging of Prostate Cancer.

Authors:  Matthias Eder; Oliver Neels; Miriam Müller; Ulrike Bauder-Wüst; Yvonne Remde; Martin Schäfer; Ute Hennrich; Michael Eisenhut; Ali Afshar-Oromieh; Uwe Haberkorn; Klaus Kopka
Journal:  Pharmaceuticals (Basel)       Date:  2014-06-30
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