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Literature DB >> 23023944

Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe.

Drew S Folk¹, Justin C Torosian, Sunhee Hwang, Dewey G McCafferty, Katherine J Franz.

Abstract

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：

Year: 2012 PMID： 23023944 PMCID： PMC3495557 DOI： 10.1002/anie.201206673

Source DB: PubMed Journal: Angew Chem Int Ed Engl ISSN： 1433-7851 Impact factor: 15.336

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35 in total

1. Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases.

Authors: Fiona Grüninger-Leitch; Daniel Schlatter; Erich Küng; Peter Nelböck; Heinz Döbeli
Journal: J Biol Chem Date: 2001-12-07 Impact factor: 5.157

2. Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

Authors: Shawn J Stachel; Craig A Coburn; Thomas G Steele; Kristen G Jones; Elizabeth F Loutzenhiser; Alison R Gregro; Hemaka A Rajapakse; Ming-Tain Lai; Ming-Chih Crouthamel; Min Xu; Katherine Tugusheva; Janet E Lineberger; Beth L Pietrak; Amy S Espeseth; Xiao-Ping Shi; Elizabeth Chen-Dodson; M Katharine Holloway; Sanjeev Munshi; Adam J Simon; Lawrence Kuo; Joseph P Vacca
Journal: J Med Chem Date: 2004-12-16 Impact factor: 7.446

3. From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).

Authors: Yuan Cheng; Ted C Judd; Michael D Bartberger; James Brown; Kui Chen; Robert T Fremeau; Dean Hickman; Stephen A Hitchcock; Brad Jordan; Vivian Li; Patricia Lopez; Steven W Louie; Yi Luo; Klaus Michelsen; Thomas Nixey; Timothy S Powers; Claire Rattan; E Allen Sickmier; David J St Jean; Robert C Wahl; Paul H Wen; Stephen Wood
Journal: J Med Chem Date: 2011-07-29 Impact factor: 7.446

4. Proteolytic activation of recombinant pro-memapsin 2 (pro-beta-secretase) studied with new fluorogenic substrates.

Authors: J Ermolieff; J A Loy; G Koelsch; J Tang
Journal: Biochemistry Date: 2000-10-10 Impact factor: 3.162

5. Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.

Authors: Xiao-Ping Shi; Katherine Tugusheva; James E Bruce; Adam Lucka; Elizabeth Chen-Dodson; Binghua Hu; Guo-Xin Wu; Eric Price; Robert B Register; Janet Lineberger; Ron Miller; Mei-Jy Tang; Amy Espeseth; Jason Kahana; Abigail Wolfe; Ming-Chih Crouthamel; Sethu Sankaranarayanan; Adam Simon; Lin Chen; Ming-Tain Lai; Beth Pietrak; Jillian DiMuzio; Yueming Li; Min Xu; Qian Huang; Victor Garsky; Mohinder K Sardana; Daria J Hazuda
Journal: J Alzheimers Dis Date: 2005-04 Impact factor: 4.472

Review 6. Genetics of Alzheimer's disease.

Authors: M Hutton; J Pérez-Tur; J Hardy
Journal: Essays Biochem Date: 1998 Impact factor: 8.000

7. BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors.

Authors: David Andrau; Cecile Dumanchin-Njock; Erwan Ayral; Jean Vizzavona; Mike Farzan; Michel Boisbrun; Pierre Fulcrand; Jean-Francois Hernandez; Jean Martinez; Solveig Lefranc-Jullien; Frederic Checler
Journal: J Biol Chem Date: 2003-05-07 Impact factor: 5.157

Monitoring β-secretase activity in living cells with a membrane-anchored FRET probe.

1. Substrate and inhibitor profile of BACE (beta-secretase) and comparison with other mammalian aspartic proteases.

2. Structure-based design of potent and selective cell-permeable inhibitors of human beta-secretase (BACE-1).

3. From fragment screening to in vivo efficacy: optimization of a series of 2-aminoquinolines as potent inhibitors of beta-site amyloid precursor protein cleaving enzyme 1 (BACE1).

4. Proteolytic activation of recombinant pro-memapsin 2 (pro-beta-secretase) studied with new fluorogenic substrates.

5. Novel mutations introduced at the beta-site of amyloid beta protein precursor enhance the production of amyloid beta peptide by BACE1 in vitro and in cells.

Review 6. Genetics of Alzheimer's disease.

7. BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors.

Review 8. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics.

Review 9. Plasma membrane microdomains: organization, function and trafficking.

10. Cell-based assay for beta-secretase activity.

1. Stimulus-Responsive Prochelators for Manipulating Cellular Metals.

2. Imaging mycobacterial growth and division with a fluorogenic probe.

Review 3. Development of Small-Molecule Fluorescent Probes Targeting Enzymes.

4. Presumed LRP1-targeting transport peptide delivers β-secretase inhibitor to neurons in vitro with limited efficiency.